WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death. Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: WW domain containing oxidoreductase, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1 , WW domain containing oxidoreductase 5330426P09Rik, 9030416C10Rik, EC 1.1.1.- Fragile site FRA16D Oxireductase, MGC55975, PRO0128, Putative oxidoreductase, zgc:55975, Short chain dehydrogenase/reductase family 41C, member 1, WW domain-containing protein WWOX. NCBI no.: AAH03184