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WDR5 encodes a member of the WD repeat protein family. Zusätzlich bieten wir Ihnen WDR5 Antikörper (105) und WDR5 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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HCMV infection increases protein levels of WD repeat-containing protein 5 (WDR5) during infection, overexpression of WDR5 enhances viral replication, and knockdown of WDR5 dramatically attenuates viral replication. The results indicate that WDR5 promotes the nuclear egress of viral capsids, the depletion of WDR5 resulting in a significant decrease in production of infectious virions.
our findings indicate that HOXD-AS1 (zeige PTGDR ELISA Kits) promotes proliferation, castration resistance, and chemo-resistance in prostate cancer by recruiting WDR5.
Functional analysis implicates TNRC6A, NAT10, MED14 (zeige MED14 ELISA Kits), and WDR5 in RNA-mediated transcriptional activation.
The decrease in WDR5 expression was particularly evident in HD-hiPSCs compared to hESCs and control-hiPSCs from healthy subjects
we demonstrate for the first time that targeted expression of miR (zeige MLXIP ELISA Kits)-31-5p using a nonviral minicircle vector can serve as a novel approach for tumor miRNA therapy. Moreover, WDR5 may be a promising therapeutic target for NPC (zeige NPC1 ELISA Kits) treatment.
WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis
WDR5 functions to sustain proper execution of DNA replication in pancreatic ductal adenocarcinoma cells, as previously suggested by replication stress studies involving MLL1, and c-Myc (zeige MYC ELISA Kits), also found to interact with WDR5.
This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 and KAT2A complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.
WDR5 shows a direct binding to the ZNF407 promoter.
Taken together, these data suggest that WDR5 is directly involved in p53 (zeige TP53 ELISA Kits) signaling pathway. Our studies provide a new insight into WDR5 functions in A549 cells.
Cbx8 associates with non-PRC1 (zeige PRC1 ELISA Kits) complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch (zeige NOTCH1 ELISA Kits) gene expression.
Wdr5 suppression also reduced IFNgamma, Il-1beta (zeige IL1B ELISA Kits), and TNFalpha (zeige TNF ELISA Kits) induced chemokine (zeige CCL1 ELISA Kits) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis
results suggest that specific RNAs are integral inputs into the WDR5-MLL complex for maintenance of the active chromatin state and embryonic stem cell fates
Data show that broad association of myc proto-oncogene protein MYC (zeige MYC ELISA Kits) with chromatin depends on interaction with the WD40-repeat protein WDR5.
BIG3 inhibits insulin (zeige INS ELISA Kits) granule biogenesis and insulin (zeige INS ELISA Kits) secretion.
BIG3 negatively regulates insulin (zeige INS ELISA Kits) granule exocytosis by restricting insulin (zeige INS ELISA Kits) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.
Depletion of KAT2B (zeige KAT2B ELISA Kits) or WDR5 decreased gluconeogenic gene expression.
analysis of a novel mechanism for epigenetic control of SMC (zeige DYM ELISA Kits)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes
Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 (zeige HIST3H3 ELISA Kits) lysine 4 by mixed lineage leukemia protein-1.
we found evidence that Setd1b, a maternally provided methyltransferase, is required for organizer gene expression. Our findings indicate that Wdr5-mediated H3K4 trimethylation plays a part in the organizer formation and dorsal axis development that are controlled by the maternal Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) pathway.
The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox (zeige MSH2 ELISA Kits) gene expression.
The results of described studies establish that WDR5 plays a significant role in porcine preimplantation embryos probably through regulating key epigenetic modifications and genome integrity.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
BMP2-induced 3-kb gene protein
, SWD3, Set1c WD40 repeat protein, homolog
, WD repeat-containing protein 5
, WD-repeat protein 5
, WD repeat-containing protein BIG-3
, WD repeat domain 5
, WD repeat domain 5B