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Vpx Protein Proteine

(Vpx Protein (VPX))
Plays a role in nuclear translocation of the viral pre- integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity). {ECO:0000250}.

2 Treffer

VPX Spezies: Human Immunodeficiency Virus (HIV) Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5710828
 
VPX Spezies: Simian Immunodeficiency Virus (SIV) Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5710778
 
  • Typ Protein
    • Protein
  • Anwendung
    • SDS-PAGE (SDS)
  • Reaktivität
    • Human Immunodeficiency Virus (HIV)
    • Simian Immunodeficiency Virus (SIV)
  • Abbildungen verfügbar
  • Wirt
    • Escherichia coli (E. coli)
  • Bindungsspezifität
    • full length
    • AA 1-112
    • AA 1-113
  • Konjugat
    • His tag
    • His-SUMO Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Liquid
  • Hersteller
    • Signalway

Aliase für Vpx Protein Proteine

vpx protein (vpx) Proteine
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