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Vpx Protein (VPX) (AA 1-113), (full length) protein (His tag)

VPX Spezies: Human Immunodeficiency Virus (HIV) Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5710828
  • Target Alle Vpx Protein (VPX) Proteine anzeigen
    Vpx Protein (VPX)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 1-113, full length
    Spezies
    Human Immunodeficiency Virus (HIV)
    Quelle
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    His tag
    Applikation
    SDS-PAGE (SDS)
    Sequenz
    MTDPRERVPP GNSGEETIGE AFEWLERTIE ALNREAVNHL PRELIFQVWQ RSWRYWHDEQ GMSASYTKYR YLCLMQKAIF THFKRGCTCW GEDMGREGLE DQGPPPPPPP GLV
    Aufreinigung
    SDS-PAGE
    Reinheit
    > 90 %
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Lagerung
    -80 °C,4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    Vpx Protein (VPX)
    Andere Bezeichnung
    VPX (VPX Produkte)
    Synonyme
    vpx protein Protein, vpx Protein
    Substanzklasse
    Viral Protein
    Hintergrund
    Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
    Molekulargewicht
    17.3 kDa
    UniProt
    P18099
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