Uromodulin Proteine (UMOD)

UMOD encodes uromodulin, the most abundant protein in normal urine. Zusätzlich bieten wir Ihnen Uromodulin Antikörper (183) und Uromodulin Kits (65) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
UMOD 7369 P07911
UMOD 22242 Q91X17
UMOD 25128 P27590
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Escherichia coli (E. coli) Ratte His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Human Human Unkonjugiert   100 μg Anmelden zum Anzeigen 6 bis 8 Tage
Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Hund Unkonjugiert 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage

UMOD Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

Weitere Proteine zu Uromodulin (UMOD) Interaktionspartnern

Human Uromodulin (UMOD) Interaktionspartner

  1. UMOD gene variants in humans fulfill the criteria for ascribing a gene as causal of Hypertension.

  2. The missense mutation p.142R>R/Q in the uromodulin gene in patients with cast Nephropathy in Multiple Myeloma.

  3. Data show that one SNP (rs183962941), located in a non-coding region of uromodulin protein (UMOD), was nominally associated with end-stage renal disease (ESRD).

  4. THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.

  5. High urinary uromodulin levels are associated with lower risk for UTI (zeige AMBP Proteine) in older community-dwelling adults independent of traditional UTI (zeige AMBP Proteine) risk factors.

  6. The uromodulin-CFH (zeige CFH Proteine) interaction enhanced the cofactor activity of CFH (zeige CFH Proteine) for factor I-mediated cleavage of C3b to inactivated C3b.

  7. These findings suggest that the levels of urinary microvesicle-bound uromodulin are associated with the severity of diabetic kidney disease.

  8. Data strongly suggest that the uromodulin ancestral allele, driving higher urinary excretion of uromodulin, has been kept at a high frequency because of its protective effect against urinary tract infections

  9. The frequency of uromodulin single nucleotide polymorphism rs13333226 GG/GA genotype was significantly higher and the frequency of G allele was much higher in the patients with end stage renal disease than in the controls.

  10. Serum uromodulin concentrations are closely correlated with estimated glomerular filtration rate, which is the recommended measure of renal function. As uromodulin is produced exclusively by renal tubular cells, the assessment of uromodulin levels in patients with chronic kidney disease may be an alternative method for evaluating the number of functioning nephrons.

Mouse (Murine) Uromodulin (UMOD) Interaktionspartner

  1. results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses

  2. Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation.

  3. Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.

  4. we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (zeige IL17A Proteine) axis and systemic neutrophilia.

  5. TNFalpha (zeige TNF Proteine) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (zeige TNF Proteine) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (zeige HNF1B Proteine)-mediated expression of uromodulin.

  6. AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS (zeige TLR4 Proteine) may contribute to its anti-inflammatory effects.

  7. UMOD upregulates TRPV5 (zeige TRPV5 Proteine) by decreasing caveolin-1 (zeige CAV1 Proteine) dependent endocytosis of TRPV5 (zeige TRPV5 Proteine).

  8. UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (zeige TNF Proteine) on NKCC2A expression, making UMOD an important determinant of blood pressure control.

  9. Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney.

  10. Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after.

Cow (Bovine) Uromodulin (UMOD) Interaktionspartner

Uromodulin (UMOD) Protein Überblick

Protein Überblick

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Genbezeichner und Symbole assoziert mit Uromodulin Proteine (UMOD)

  • uromodulin (UMOD)
  • uromodulin (Umod)
  • ADMCKD2 Protein
  • FJHN Protein
  • HNFJ Protein
  • HNFJ1 Protein
  • MCKD2 Protein
  • THGP Protein
  • THP Protein
  • urehr4 Protein

Bezeichner auf Proteinebene für Uromodulin Proteine (UMOD)

uromodulin , Tamm-Horsfall urinary glycoprotein , uromucoid , THP , tamm-Horsfall urinary glycoprotein , uromodulin (uromucoid, Tamm-Horsfall glycoprotein) , Urmodulin (Tamm-Horsfall protein) , uromucoid, human : Tamm-Horsfall glycoprotein

695883 Macaca mulatta
100026222 Monodelphis domestica
7369 Homo sapiens
403510 Canis lupus familiaris
22242 Mus musculus
25128 Rattus norvegicus
281567 Bos taurus
100730507 Cavia porcellus
100173805 Pongo abelii
100511125 Sus scrofa
100342440 Oryctolagus cuniculus
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