anti-Ubiquitin Specific Peptidase 8 (USP8) Antikörper

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Zusätzlich bieten wir Ihnen USP8 Kits (18) und USP8 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
USP8 9101 P40818
USP8 296121  
USP8 84092 Q80U87
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Top anti-USP8 Antikörper auf antikoerper-online.de

Showing 10 out of 94 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-USP8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: HCT15 cell lysate USP8 is supported by BioGPS gene expression data to be expressed in HCT15 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-USP8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate WB Suggested Anti-USP8  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control:.93T cell lysate  USP8 is supported by BioGPS gene expression data to be expressed in HEK293T 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$265.00
Details
Human Kaninchen Unkonjugiert WB The anti-USP8 Pab (ABIN388890) is used in Western blot to detect USP8 in transfected 293T cells. Data is kindly provided by Lily Yen from University of California Davis (Davis, CA). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-USP8 Pab (ABIN388891) is used in Western blot to detect USP8 in transfected 293T cells. Data is kindly provided by Lily Yen from University of California Davis (Davis, CA). USP8-C1072 (ABIN388891) western blot analysis in WiDr cell line lysates (35 µg/lane).This demonstrates the USP8 antibody detected the USP8 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IP, IHC (p), WB ICC/IF Image USP8 antibody detects USP8 protein at cytoplasm by immunofluorescent analysis. Sample: A549 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: USP8 protein stained by USP8 antibody , diluted at 1:500. Blue: Hoechst 33342 staining. WB Image Sample (30 ug of whole cell lysate) A: H1299 B: HCT116 5% SDS PAGE antibody diluted at 1:5000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Huhn Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details

Weitere Antikörper gegen USP8 Interaktionspartner

Human Ubiquitin Specific Peptidase 8 (USP8) Interaktionspartner

  1. High expression of USP8 was correlated with advanced tumor stage and high recurrence risk. Moreover, USP8 was identified as a novel independent prognostic factor for CSCC (zeige CYP11A1 Antikörper) patients.

  2. In summary, we show that, contrary to the pituitary ACTH (zeige POMC Antikörper)-secreting tumors, the USP8 hotspot sequence on exon 14 is not mutated in tumors causing ectopic ACTH (zeige POMC Antikörper) secretion syndrome (EAS). Although USP8 is expressed in all EAS tumors examined, our in vitro data indicate that it is not involved in the regulation of ectopic proopiomelanocortin (zeige POMC Antikörper) transcription.

  3. USP8 deubiquitinates Sec31A (zeige SEC31A Antikörper) and inhibits the formation of large COPII carriers, thereby suppressing collagen IV (zeige COL4 Antikörper) secretion.

  4. review: role of USP8 driver mutations in Cushing's Disease

  5. Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A (zeige CLEC16A Antikörper), NRDP1 (zeige RNF41 Antikörper), and USP8 form tripartite complex; CLEC16A (zeige CLEC16A Antikörper)-NRDP1 (zeige RNF41 Antikörper)-USP8 complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A (zeige CLEC16A Antikörper) = C-type lectin domain family 16 member A (zeige CLEC16A Antikörper); NRDP1 (zeige RNF41 Antikörper) = ubiquitin-protein ligase (zeige UBE2K Antikörper) NRDP1 (zeige RNF41 Antikörper); USP8 = ubiquitin specific peptidase 8)

  6. the EGFR (zeige EGFR Antikörper)-USP8-trichoplein-Aurora A (zeige AURKA Antikörper) axis is a critical signaling cascade that restricts ciliogenesis in dividing cells, and functions to facilitate cell proliferation

  7. in human cells, Usp8 knockdown increased the lysosomal degradation of alpha-synuclein.

  8. Overexpression of USP8 in lung adenocarcinoma is an early event during the course of tumor progression, and is related to EGFR (zeige EGFR Antikörper) expression.

  9. Somatic mutations in USP8 are common in Nelson's tumors, and are associated with less favorable outcome after surgery.

  10. Data indicate that USP8 functions as a novel deubiquitylase of FLIPL and inhibits extrinsic apoptosis by stabilizing FLIPL.

Mouse (Murine) Ubiquitin Specific Peptidase 8 (USP8) Interaktionspartner

  1. the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome.

  2. in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions.

  3. The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.

  4. a role for the USP8.STAM (zeige STAM Antikörper) complex as a protective mechanism regulating early endosomal sorting of EGFR (zeige EGFR Antikörper) between pathways destined for lysosomal degradation and recycling.

  5. USP8 was able to interact with spermatid endosomal-sorting complex required for transport-0 and microtubule structures; USP8 can directly link, via its MIT domain, the labeled vesicles/developing acrosome to microtubules.

  6. in wobbler testis expression of mouse ubiquitin-specific processing protease (mUBPy)is up-regulated, while a differential sorting of the protein characterizes wobbler spermatids where acrosome formation is impaired

  7. Data indicate a novel mechanism where diacylglycerol kinase delta (zeige DGKD Antikörper) and protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper) modulate the levels of ubiquitinated epidermal growth factor (zeige EGF Antikörper) receptors through Akt (zeige AKT1 Antikörper) and ubiquitin-specific protease 8.

  8. deubiquitinating enzyme specifically expressed in testis (zeige XKR3 Antikörper), associates with the acrosome and centrosome in mouse germ cells

  9. Results indicate that Nrdp1 (zeige RNF41 Antikörper) is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 (zeige RNF41 Antikörper) activity by mediating its stabilization.

  10. We conclude that UBPY negatively regulates the rate of EGFR (zeige EGFR Antikörper) down-regulation by deubiquitinating EGFR (zeige EGFR Antikörper) on endosomes.

USP8 Antigen-Profil

Protein Überblick

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

Genbezeichner und Symbole assoziert mit USP8

  • ubiquitin carboxyl-terminal hydrolase 8 (LOC9310109) Antikörper
  • ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369) Antikörper
  • ubiquitin specific peptidase 8 (USP8) Antikörper
  • ubiquitin specific peptidase 8 (Usp8) Antikörper
  • AI574262 Antikörper
  • AW557536 Antikörper
  • HumORF8 Antikörper
  • mKIAA0055 Antikörper
  • Ubpy Antikörper

Bezeichner auf Proteinebene für USP8

ubiquitin carboxyl-terminal hydrolase 8 , ubiquitin-specific-processing protease 8 , ubiquitin specific peptidase 8 , ubiquitin carboxyl-terminal hydrolase 8-like , deubiquitinating enzyme 8 , hUBPy , ubiquitin isopeptidase Y , ubiquitin specific protease 8 , ubiquitin thioesterase 8 , ubiquitin thiolesterase 8 , putative deubiquitinating enzyme

GENE ID SPEZIES
9310109 Arabidopsis lyrata subsp. lyrata
10031598 Arthroderma gypseum CBS 118893
100408559 Callithrix jacchus
100437819 Pongo abelii
9101 Homo sapiens
296121 Rattus norvegicus
84092 Mus musculus
100157546 Sus scrofa
415451 Gallus gallus
100351436 Oryctolagus cuniculus
100720255 Cavia porcellus
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