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Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Zusätzlich bieten wir Ihnen USP7 Antikörper (229) und viele weitere Produktgruppen zu diesem Protein an.
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reveal a conserved mechanism by which Ci/Gli (zeige GLI1 Proteine) is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers
Genetic and gene expression analyses suggested that GMPS (zeige GMPS Proteine)/USP7 acts as a transcriptional corepressor
GMP synthetase (zeige GMPS Proteine) stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
Pit1 (zeige POU1F1 Proteine) deletion inhibited USP7/IRS1 (zeige IRS1 Proteine) dissociation upon insulin (zeige INS Proteine) stimulation.
EPOP (E130012A19Rik) interacts with elongin B (zeige TCEB2 Proteine), elongin C (zeige TCEB1 Proteine), and USP7 to modulate the chromatin landscape.
USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.
Findings demonstrate a crucial role of HAUSP in regulating N-Myc (zeige MYCN Proteine) function in neuroblastoma (zeige ARHGEF16 Proteine) in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN (zeige MYCN Proteine)-amplified tumors.
The present study identified USP7 and TDP-43 (zeige TARDBP Proteine) as the regulators of CRY1 (zeige CRY1 Proteine) and CRY2 (zeige CRY2 Proteine), underscoring the significance of the stability control process of CRY (zeige CRY2 Proteine) proteins for period determination in the mammalian circadian clockwork.
demonstrate that genotoxic stress stimulates Cry1 (zeige CRY1 Proteine) phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 (zeige CRY1 Proteine) and shifting circadian clock time
Our results demonstrate that the SCML2 (zeige SCML2 Proteine)/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis
USP7-mediated mono-deubiquitination of FoxO1 (zeige FOXO1 Proteine) results in suppression of FoxO1 (zeige FOXO1 Proteine) transcriptional activity through decreased FoxO1 (zeige FOXO1 Proteine) occupancy on the promoters of gluconeogenic genes.
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 (zeige KAT5 Proteine).
The ubiquitination-deubiquitination cascade mediated by the TRIM27 (zeige RFP Proteine)-USP7 complex plays an important role in TNF-alpha (zeige TNF Proteine)-induced apoptosis.
REVIEW: USP7 plays crucial roles in diverse array of cellular and biological processes including tumour suppression, cell cycle, DNA repair, chromatin remodelling, and epigenetic regulation.
USP7 depletion in APC (zeige APC Proteine)-mutated colorectal cancer inhibits Wnt (zeige WNT2 Proteine) activation by restoring beta-catenin (zeige CTNNB1 Proteine) ubiquitination, drives differentiation, and suppresses xenograft tumor growth.
USP7 is RNF169 (zeige RNF169 Proteine) interacting protein.Expression of USP7 and RNF169 (zeige RNF169 Proteine) positively correlated in breast cancer.
protein deubiquitinase USP7 is an essential player in osteogenic differentiation of Human adipose-derived stem cells.
ubiquitin-specific protease 7 (USP7) deubiquitinase targeting by vIRF-3 (in addition to previously reported USP7 binding by vIRF-1 and vIRF-4); the importance of vIRF-1 and vIRF-3 interactions with USP7 for latent PEL cell growth and viability; and the positive and negative contributions, respectively, of USP7 targeting by vIRF-1 and vIRF-3 to HHV-8 productive replication.
demonstrate that both USP7 and various USP7 substrates are subjected to Lys48-mediated ubiquitin modification, consistent with increased proteasomal degradation of these proteins because of USP7 inhibition
Here we study the transition between USP7 states. We provide a crystal structure of USP7(CD123 (zeige IL3RA Proteine)) and show that catalytic domain CD and the first 3 Ubl domains Ubl123 are connected via an extended charged alpha helix. Mutational analysis is used to determine whether the charge and rigidity of this 'connector helix' are important for full USP7 activity
the overexpression of USP7 might promote cell proliferation by deubiquitinating Ki-67 (zeige MKI67 Proteine) protein
these data identify DUB3 (zeige USP17L2 Proteine) and USP7 as factors that regulate DNA replication by controlling Geminin protein (zeige GMNN Proteine) stability, and suggest that USP7 may be involved in Geminin (zeige GMNN Proteine) dysregulation during breast cancer progression.
Molecular mechanisms of USP7 substrate recognition and C-terminal activation have been described.
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).
, ubiquitin specific peptidase 7 (herpes virus-associated)
, ubiquitin carboxyl-terminal hydrolase 7-like
, deubiquitinating enzyme 7
, herpesvirus-associated ubiquitin-specific protease
, ubiquitin carboxyl-terminal hydrolase 7
, ubiquitin specific protease 7
, ubiquitin thioesterase 7
, ubiquitin thiolesterase 7
, ubiquitin-specific-processing protease 7
, Herpes virus-associated ubiquitin-specific protease
, ubiquitin specific protease 7 (herpes virus-associated)
, herpes-virus-associated ubiquitin-specific protease
, ubiquitin-specific peptidase 7