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USP2 encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. Zusätzlich bieten wir Ihnen USP2 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal USP2 Primary Antibody für IHC (p), WB - ABIN388879
Stevenson, Sparks, Allende-Vega, Xirodimas, Lane, Saville: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. in The EMBO journal 2007
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Human Polyclonal USP2 Primary Antibody für IHC (p) - ABIN2477040
Bryc, Zlomaniec: [Direct magnification technic as a method of further improving the diagnostic value of cerebral angiography]. in Neurologia i neurochirurgia polska 1976
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Human Polyclonal USP2 Primary Antibody für IHC (p), WB - ABIN388877
Priolo, Tang, Brahamandan, Benassi, Sicinska, Ogino, Farsetti, Porrello, Finn, Zimmermann, Febbo, Loda: The isopeptidase USP2a protects human prostate cancer from apoptosis. in Cancer research 2006
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Human Polyclonal USP2 Primary Antibody für - ABIN1882149
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Polyclonal USP2 Primary Antibody für WB - ABIN388878
Alonso, Magyar, Wang, Bisello, Friedman: Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011
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Authors show here USP2 is expressed in quiescent and activated T-cells and its expression is 50% lower in CTCL (zeige TSPYL2 Antikörper) cell lines (MyLa2000, SeAx and Hut-78) than in normal T-cells.
Data show that ubiquitin variants (Ubvs) that bind to USP2 or USP21 (zeige USP21 Antikörper) contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.
The results show a connection between miR (zeige MLXIP Antikörper)-125b and USP2 gene the etiology of psoriasis. They proceeded to show that modulation of nuclear factor kappa B-mediated inflammation is the likely mechanism through which this miRNA gene pair function
the deubiquitinase USP2a translocates into the nucleus and binds to pY701-STAT1 (zeige STAT1 Antikörper), and inhibits K48-linked ubiquitination and degradation of pY701-STAT1 (zeige STAT1 Antikörper)
ML364 also caused a decrease in homologous recombination-mediated DNA repair. These effects by a small molecule inhibitor support a key role for USP2 as a regulator of cell cycle (zeige C13orf15 Antikörper), DNA repair, and tumor cell growth.
Identify USP2 as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR (zeige LDLR Antikörper) by IDOL (zeige MYLIP Antikörper).
Data suggest up-regulation of ASAH1 (acid ceramidase (zeige ASAH1 Antikörper)) activity by androgen in androgen-sensitive prostate cancer cells (but not other cancer cells) is mainly due to prolonged stability of ASAH1 (zeige ASAH1 Antikörper) by androgen-stimulated induction of USP2 expression.
Modulation of USP-2 expression plays a crucial role in cell cycle regulation by leptin and adiponectin.
The present study showed that USP2 expression is associated with TNBC cell line's invasiveness and poor survival of breast cancer patients and may serve as a prognostic biomarker and therapeutic target for TNBC
findings demonstrated that USP2b deubiquitinates K63-linked polyubiquitin (zeige UBB Antikörper) chains from TBK1 (zeige TBK1 Antikörper) to terminate TBK1 (zeige TBK1 Antikörper) activation and negatively regulate IFN-beta (zeige IFNB1 Antikörper) signaling and antiviral immune response.
Usp2 is required for the PTH1 (zeige PTH Antikörper)-34-induced proliferation of osteoblasts
Usp2 is a clock output effector related to bodily Ca2 (zeige CA2 Antikörper)+ homeostasis, a feature that is conserved across evolution.
A novel function of USP2 in the molecular clock in which it regulates PER1 (zeige PER1 Antikörper) function.
A role for USP2-45 as a central regulator of MR, able to remove the receptor monoubiquitylation and induced its destabilization.
Data suggest that USP2 does not play a primary role in the control of sodium balance or blood pressure.
a functional liver clock is required for the proper nutritional and circadian regulation of USP2-45 expression; at the molecular level, transcriptional coactivators PGC-1alpha and PGC-1beta (zeige PPARGC1B Antikörper) and repressor E4BP4 (zeige NFIL3 Antikörper) exert opposing effects on USP2-45 promoter activity
USP2a potentially mediates circadian disruption by suppressing the CRY1 (zeige CRY1 Antikörper) degradation during inflammation.
Rhythmic expression of USP2 in the SCN (zeige SRI Antikörper) and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes
severe defect in the ability of Usp2 -/- spermatozoa to fertilize eggs
TNFalpha (zeige TNF Antikörper)-induced USP2 down-regulation is an effective cytoprotective mechanism in hepatocytes.
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
41 kDa ubiquitin-specific protease
, deubiquitinating enzyme 2
, ubiquitin carboxyl-terminal hydrolase 2
, ubiquitin specific protease 12
, ubiquitin specific protease 9
, ubiquitin thioesterase 2
, ubiquitin-specific-processing protease 2
, ubiquitin specific protease 2
, ubiquitin thiolesterase 2
, ubiquitin-specific-processing protease testis
, family of cysteine protease
, ubiquitin specific protease 41
, ubiquitin specific protease 46
, ubiquitin specific protease 52
, ubiquitin specific protease 66