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USP16 encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition.
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Cow (Bovine) Polyclonal USP16 Primary Antibody für ELISA - ABIN4364551
Joo, Zhai, Yang, Nie, Erdjument-Bromage, Tempst, Chang, Wang: Regulation of cell cycle progression and gene expression by H2A deubiquitination. in Nature 2007
USP16 was frequently downregulated.
USP16 and TTC3 (zeige TTC3 Antikörper) were dysregulated in all affected human cells and two mouse models of Down syndrome.
The data unveil a unique mechanism by which Usp16 promotes the localization and maintenance of Plk1 (zeige PLK1 Antikörper) on the kinetochores for proper chromosome alignment.
Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.
S552P disrupts the interaction between Ubp-M and nuclear export protein CRM1 (zeige XPO1 Antikörper), increasing Ubp-M nuclear retention as cells progress into M phase, revealing a critical function for Ubp-M S552P.
in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and postnatal neural progenitors, whereas downregulation of USP16 partially rescues the proliferation defects of Down's syndrome fibroblasts
Study reports the solution structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ubiquitin; the Ubp-M BUZ domain features three zinc-binding sites consisting of 12 residues.
knockdown of Ubp-M in HeLa cells results in slow cell growth rates owing to defects in the mitotic phase of the cell cycle
a new cryptic USP16-RUNX1 (zeige RUNX1 Antikörper) fusion in chronic myelomonocytic leukemia
USP16 (zeige USP21 Antikörper) and TTC3 (zeige TTC3 Antikörper) were dysregulated in all affected human cells and two mouse models of Down syndrome.
these studies identified Usp16 (zeige USP21 Antikörper) as one of the histone H2A deubiquitinases, which coordinates with the H2A ubiquitin ligase (zeige RNF123 Antikörper) PRC1 (zeige PRC1 Antikörper) to regulate hematopoiesis, and revealed cell cycle regulation by Usp16 (zeige USP21 Antikörper) as key for HSC (zeige FUT1 Antikörper) differentiation.
study identifies Usp16 and H2A deubiquitination as critical regulators of ESC gene expression and differentiation
results suggest that USP16 (zeige USP21 Antikörper) has an important role in antagonizing the self-renewal and/or senescence pathways in Down's syndrome and could serve as an attractive target to ameliorate some of the associated pathologies
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
universal stress protein
, ubiquitin specific peptidase 16
, Deubiquitinating enzyme 16
, Ubiquitin thioesterase 16
, Ubiquitin-specific-processing protease 16
, ubiquitin carboxyl-terminal hydrolase 16
, ubiquitin thiolesterase 16
, ubiquitin specific protease 16
, deubiquitinating enzyme 16
, ubiquitin thioesterase 16
, ubiquitin-specific-processing protease 16
, ubiquitin-processing protease UBP-M
, ubiquitin-specific processing protease 16