anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) Antikörper

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. Zusätzlich bieten wir Ihnen UBR1 Kits (12) und UBR1 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
UBR1 197131 Q8IWV7
UBR1 22222 O70481
UBR1 499877  
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Top anti-UBR1 Antikörper auf antikoerper-online.de

Showing 10 out of 54 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-UBR1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HepG2/Jurkat cells, using UBR1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Human Kaninchen Unkonjugiert IHC, WB   200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Maus Kaninchen Unkonjugiert WB Western blot analysis in mouse liver tissue lysates (35ug/lane). 400 μL Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: UBR1 Antibody  - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB   100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details

Am meisten referenzierte anti-UBR1 Antikörper

  1. Mouse (Murine) Polyclonal UBR1 Primary Antibody für WB - ABIN1881972 : Alkhouri, Kaplan, Kay, Shealy, Crowe, Bauhuber, Zenker: Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing. in World journal of gastroenterology : WJG 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal UBR1 Primary Antibody für ELISA, WB - ABIN566929 : Ozawa, Nakao, Kurihara, Shimazaki, Shimmura, Ishida, Yoshimura, Tsubota, Okano: Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. in The Journal of biological chemistry 2008 (PubMed)

  3. Cow (Bovine) Polyclonal UBR1 Primary Antibody für WB - ABIN2781277 : Yamaguchi, Moritani, Tanahashi, Osabe, Nomura, Fujita, Keshavarz, Kunika, Nakamura, Yoshikawa, Ichiishi, Shiota, Yasui, Inoue, Itakura: Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population. in BMC medical genetics 2008 (PubMed)

Weitere Antikörper gegen UBR1 Interaktionspartner

Caenorhabditis elegans (C. elegans) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) Interaktionspartner

  1. results raise an intriguing possibility that UBR proteins regulate glutamate (zeige GRIN2A Antikörper) metabolism, which is critical for neuronal development and signaling

  2. show that CED-3 caspase (zeige CASP3 Antikörper) and the E3 ubiquitin ligase (zeige MUL1 Antikörper) UBR-1 form a complex that couples their in vivo activities, allowing for recognition and rapid degradation of LIN-28

Human Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) Interaktionspartner

  1. UBR1 mutations of single or multi-exon deletions or duplications account for a substantial proportion of Johanson-Blizzard syndrome.

  2. Reduced UBR1 expression affects MGMT (zeige MGMT Antikörper) turnover and DNA repair in the smokers lungs.

  3. For all previously reported and novel UBR1 mutations together with their clinical data, a mutation database has been established at LOVD.

  4. Testing the fetus and the affected sibling with recurrent Johanson-Blizzard syndrome revealed a homozygous truncating mutation in UBR1.

  5. Results confirmed the relevance of specific missense UBR1 alleles to JBS, and suggested that a residual activity of a missense allele is causally associated with milder variants of JBS.

  6. Molecular studies revealed a novel homozygous nonsense mutation in exon 38 of the UBR1 gene, which confirmed the diagnosis of Johanson-Blizzard syndrome.

  7. Ubc2 (zeige ube2a Antikörper)/Rad6 ser (zeige SIGLEC1 Antikörper)(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1

  8. Deficiency of UBR1 perturbs the pancreas' acinar cells and other organs, presumably owing to metabolic stabilization of specific substrates of the N-end rule pathway.

  9. Sustained ERK5 activity and the E3 ligase UBR1 regulate the stability and subcellular localization of c-Fos.

  10. Thus we propose that autoISGylation of EFP (zeige TRIM25 Antikörper) negatively regulates its ISG15 (zeige ISG15 Antikörper) E3 ligase activity for 14-3-3sigma.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) Interaktionspartner

  1. involved in learning and memory; behavioral characterizations of UBR1 knockout mice

  2. UBR1-/-UBR2 (zeige UBR2 Antikörper)-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.

  3. TLX1/HOX11 (zeige TLX1 Antikörper) overexpression and Ubr1 inactivation in promoting chromosome missegregation, permitting the accrual of additional chromosome losses and cytogenic abnormalities en route to malignancy

  4. A STAT3 (zeige STAT3 Antikörper)-dependent E3 ubiquitin ligase (zeige MUL1 Antikörper), Ubr1, was responsible for rhodopsin (zeige RHO Antikörper) degradation and was up-regulated in the inflamed SOCS3 (zeige SOCS3 Antikörper)-deficient retinas.

UBR1 Antigen-Profil

Protein Überblick

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Genbezeichner und Symbole assoziert mit UBR1

  • Ubr1 ubiquitin ligase (Ubr1) Antikörper
  • ubiquitin protein ligase E3 component n-recognin 1 (ubr1) Antikörper
  • ubiquitin protein ligase E3 component n-recognin 1 (UBR1) Antikörper
  • E3 ubiquitin-protein ligase ubr-1 (ubr-1) Antikörper
  • ubiquitin protein ligase E3 component n-recognin 1 (Ubr1) Antikörper
  • AI504731 Antikörper
  • Dmel\\CG9086 Antikörper
  • JBS Antikörper
  • RGD1562326 Antikörper
  • UBR1 Antikörper

Bezeichner auf Proteinebene für UBR1

CG9086-PA , CG9086-PB , ubiquitin protein ligase E3 component n-recognin 1 , E3 ubiquitin-protein ligase UBR1 , E3a ligase , N-recognin-1 , ubiquitin ligase E3 alpha-I , ubiquitin-protein ligase E3-alpha , ubiquitin-protein ligase E3-alpha-1 , ubiquitin-protein ligase E3-alpha-I , E3 alpha , ubiquitin-protein ligase e3 componen n-recognin

GENE ID SPEZIES
32687 Drosophila melanogaster
568531 Danio rerio
100010751 Monodelphis domestica
100056497 Equus caballus
100511299 Sus scrofa
100558444 Anolis carolinensis
171953 Caenorhabditis elegans
197131 Homo sapiens
22222 Mus musculus
487521 Canis lupus familiaris
522464 Bos taurus
499877 Rattus norvegicus
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