UBR1 Antikörper (N-Term)

Produktnummer ABIN1881972

Produktdetails anti-UBR1 Antikörper

Target: UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))

Bindungsspezifität: AA 245-274, N-Term

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.

Klon: RB41861

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-UBR1 Antikörper (ABIN1881972)

Alkhouri, Kaplan, Kay, Shealy, Crowe, Bauhuber, Zenker: "Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing." in: World journal of gastroenterology : WJG, Vol. 14, Issue 44, pp. 6863-6, (2008) (PubMed).

Wei, Lin, Yang, Wang, Chang, Chen, Chen et al.: "Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of..." in: Molecular pharmacology, Vol. 72, Issue 3, pp. 725-33, (2007) (PubMed).

Details zu UBR1

Target: UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))

Andere Bezeichnung: UBR1 (UBR1 Produkte)

Synonyme: Dmel\\CG9086 antikoerper, Ubr1 antikoerper, UBR1 antikoerper, JBS antikoerper, AI504731 antikoerper, RGD1562326 antikoerper, Ubr1 ubiquitin ligase antikoerper, ubiquitin protein ligase E3 component n-recognin 1 antikoerper, E3 ubiquitin-protein ligase ubr-1 antikoerper, Ubr1 antikoerper, ubr1 antikoerper, UBR1 antikoerper, ubr-1 antikoerper

Hintergrund: The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Molekulargewicht: 200211

NCBI Accession: NP_777576

UniProt: Q8IWV7