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This intronless gene encodes a carcinoma-associated antigen. Zusätzlich bieten wir Ihnen TACSTD2 Antikörper (179) und TACSTD2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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TACSTD2 downregulation is associated with hepatocellular carcinoma.
findings demonstrate that a membranous TROP-2 staining pattern is highly specific for PTC (zeige F9 Proteine), which may serve as a potential diagnostic marker aiding in the accurate classification of morphologically equivocal thyroid follicular-patterned lesions
TROP2 promoted the proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) pathway and inducing EMT (zeige ITK Proteine).
The results from clinical specimens showed that Trop2 expression correlated with MMP2 (zeige MMP2 Proteine) expression in primary thyroid cancer. The current study suggests that elevated expression of Trop2 may represent an important molecular hallmark that is biologically and clinically relevant to the progression of thyroid cancer.
these results suggest a differential role for TROP2 in different lung cancer subtypes
Results show that TROP2 expression is up-regulated in gastric tumor and its co-expression with AREG (zeige AREG Proteine) protein is associated with TNM (zeige ODZ1 Proteine) stage, tumor size, lymph node metastases, and distant metastases.
Our findings indicate that the expression of Trop-2 is a stringent predictor of tumor response to AKT (zeige AKT1 Proteine) inhibitors. They also support the identification of target-activatory pathways, as efficient predictors of response in precision cancer therapy.
Findings suggest that high TROP2 expression identifies distinct cell sub-populations in androgen-sensitive and androgen-independent prostate tumors and that it may be a predictive biomarker for prostate cancer treatment response in androgen-sensitive tumors.
TROP2 may play a crucial role in COPD (zeige ARCN1 Proteine) by affecting basal cells function and thus airway remodeling through increased basal cells hyperplasia
TROP2 was overexpressed specifically in the majority of epithelial ovarian cancer and may be a novel prognostic biomarker
studies have begun to identify the mechanisms underlying TROP2's functions, including regulated intramembrane proteolysis or specific interactions with integrin b1 and claudin proteins.
Trop2 is a regulator of self-renewal, proliferation, and transformation
TROP2 modulates the interaction between the cells and matrix and regulates the formation of the ureteric duct by suppressing branching from the trunk during kidney development.
these results uncover a role for Trop2 loss in tumorigenesis and the mesenchymal transdifferentiation observed in a subset of squamous cell carcinomas.
In human and mouse, Trop2 is highly expressed at both the transcript and protein levels on several essential normal tissues.
Study also provides the first indication of a molecular signaling pathway activated by Trop2 which has important implications for cancer cell growth and survival.
Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.
Data show that cleaved PRP1 proliferates endothelial cells in vitro, and suggest that endothelial cell proliferation activity of cleaved PRP1 may be shared in specific bovine placentomal angiogenesis.
placental prolactin-related protein-I is identified as a major target of bovine binucleate trophoblast giant cell lectin binding
Identified novel prolactin (zeige PRL Proteine)-related proteins (PRPs (zeige MSMB Proteine)) in caprine placenta, and indicated that PRP (zeige PRNP Proteine) genes in caprine placenta have coordination functions for gestation, as they do in bovine.
Interaction of bPRP-I with type IV collagen (zeige COL4 Proteine) suggests that bPRP-I accumulates in extracellular matrix where it likely acts on cells traversing the bovine placentome.
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
40kD glycoprotein, identified by monoclonal antibody GA733
, cell surface glycoprotein TROP2
, cell surface glycoprotein Trop-2
, epithelial glycoprotein-1
, gastrointestinal tumor-associated antigen GA7331
, membrane component chromosome 1 surface marker 1
, membrane component, chromosome 1, surface marker 1
, pancreatic carcinoma marker protein GA733-1
, pancreatic carcinoma marker protein GA7331
, lymphocyte antigen 97
, tunor-associated calcium signal transducer 2
, parturition-related protein 1
, placental prolactin-related protein 1
, tumor-associated calcium signal transducer 2
, tumor associated calcium signal transducer 2