Tumor-Associated Calcium Signal Transducer 2 Proteine (TACSTD2)

Human Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) Interaktionspartner

1. Study demonstrated that TROP2 expression was increased in glioblastoma tissues and glioblastoma cell lines. High TROP2 expression was significantly correlated with the poor survival of glioblastoma patients.

2. The results suggest that TROP2 expression could be an effective prognostic biomarker for oral squamous cell carcinoma

3. TROP-2, SLP-2 and CD56 were effective diagnostic markers for PTC, especially when they were combined to use.

4. Trop2 has a potential role in the promotion of EMT in BC.

5. these results suggested that TROP2 may promote osteosarcoma cell proliferation and migration via PI3K/AKT signaling and may serve as a novel treatment target for osteosarcoma .

6. TACSTD2 downregulation is associated with hepatocellular carcinoma.

7. findings demonstrate that a membranous TROP-2 staining pattern is highly specific for PTC, which may serve as a potential diagnostic marker aiding in the accurate classification of morphologically equivocal thyroid follicular-patterned lesions

8. TROP2 promoted the proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT.

9. The results from clinical specimens showed that Trop2 expression correlated with MMP2 expression in primary thyroid cancer. The current study suggests that elevated expression of Trop2 may represent an important molecular hallmark that is biologically and clinically relevant to the progression of thyroid cancer.

10. these results suggest a differential role for TROP2 in different lung cancer subtypes

11. Results show that TROP2 expression is up-regulated in gastric tumor and its co-expression with AREG protein is associated with TNM stage, tumor size, lymph node metastases, and distant metastases.

12. Our findings indicate that the expression of Trop-2 is a stringent predictor of tumor response to AKT inhibitors. They also support the identification of target-activatory pathways, as efficient predictors of response in precision cancer therapy.

13. Findings suggest that high TROP2 expression identifies distinct cell sub-populations in androgen-sensitive and androgen-independent prostate tumors and that it may be a predictive biomarker for prostate cancer treatment response in androgen-sensitive tumors.

14. TROP2 may play a crucial role in COPD by affecting basal cells function and thus airway remodeling through increased basal cells hyperplasia

15. TROP2 was overexpressed specifically in the majority of epithelial ovarian cancer and may be a novel prognostic biomarker

16. we compared the diagnostic value of TROP-2 expression in distinguishing between benign and malignant thyroid lesions to those of HBME-1, CK19 and galectin-3

17. TROP-2 membranous staining is a very sensitive and specific marker for the classic and tall cell variants of papillary thyroid carcinoma, and for papillary microcarcinomas , with high overall specificity for papillary thyroid carcinoma

18. The results suggested that trop2 facilitated neovascularization of non-small-cell lung cancer via activating ERK1/2 signaling pathway.

19. We identified a homozygous TACSTD2 missense mutation, c.551A>G, p.(Tyr184Cys), in the affected family members. Both parents were heterozygous for the mutation, and unaffected siblings were either heterozygous or homozygous wild-type for this allele.

20. Our results expand the mutational spectrum of TACSTD2 in patients with gelatinous drop-like corneal dystrophy (GDLD).

Mouse (Murine) Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) Interaktionspartner

1. studies have begun to identify the mechanisms underlying TROP2's functions, including regulated intramembrane proteolysis or specific interactions with integrin b1 and claudin proteins.

2. Trop2 is a regulator of self-renewal, proliferation, and transformation

3. TROP2 modulates the interaction between the cells and matrix and regulates the formation of the ureteric duct by suppressing branching from the trunk during kidney development.

4. these results uncover a role for Trop2 loss in tumorigenesis and the mesenchymal transdifferentiation observed in a subset of squamous cell carcinomas.

5. In human and mouse, Trop2 is highly expressed at both the transcript and protein levels on several essential normal tissues.

6. Study also provides the first indication of a molecular signaling pathway activated by Trop2 which has important implications for cancer cell growth and survival.

7. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.