Tumor Necrosis Factor Receptor Superfamily, Member 18 Proteine (TNFRSF18)

TNFRSF18 encodes a member of the TNF-receptor superfamily. Zusätzlich bieten wir Ihnen TNFRSF18 Antikörper (306) und TNFRSF18 Kits (21) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNFRSF18 21936 O35714
TNFRSF18 8784 Q9Y5U5
TNFRSF18 500598  
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Top TNFRSF18 Proteine auf antikoerper-online.de

Showing 10 out of 41 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
Human Cells Human His tag,ECD 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
Baculovirus infected Insect Cells Human hIgG-His-tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
HEK-293 Cells Human His tag Human GITR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. Immobilized Human GITR, His Tag (Cat# GIR-H5228) at 2 μg/mL (100 μl/well) can bind Human GITR Ligand, Fc Tag (Cat# GIL-H526a ) with a linear range of 0.8-25 ng/mL. 100 μg Anmelden zum Anzeigen 5 Days
HEK-293 Cells Maus Fc Tag   50 μg Anmelden zum Anzeigen 5 bis 8 Tage
HEK-293 Cells Human Fc Tag   50 μg Anmelden zum Anzeigen 5 bis 8 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Human Cells Ratte Fc Tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

TNFRSF18 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) , ,
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Rat (Rattus) ,

Weitere Proteine zu Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) Interaktionspartnern

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) Interaktionspartner

  1. These results suggest that therapeutically targeting GITR represents a unique approach to cancer immunotherapy and suggests that a multimeric fusion protein may provide increased agonistic potential versus an antibody

  2. These findings support further study into combination partners for GITRL-FP that may augment CD8 T-cell priming as well as provide hypotheses that can be tested in human clinical trials exploring GITR agonists including GITRL-FP.

  3. Expression of human GITR was comparable with that of mouse GITR in tumor-infiltrating Tregs despite being drastically lower in other human TILs and in many human peripheral blood populations.

  4. anti-GITR mAb shifts Treg populations to enable immune attack on tumors, with clinical implications for molecular markers to modify emerging treatments.

  5. Continuous GITR stimulation through B cell Gitrl acts protective in a mouse model of atherosclerosis by regulating the balance between regulatory and effector memory CD4(+) T cells.

  6. these results indicate that blockade of GITR signaling can ameliorate arthritis progression mainly by modulating the follicular helper T cell response

  7. GITR appears as a potential target for intervention during infection by the parasite Toxoplasma gondii, even though further studies are still necessary to better characterize the immune response triggered by GITR activation during T. gondii infection

  8. our data suggest a critical role for GITR in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior

  9. These findings provide further support for the continued development of agonist anti-GITR antibodies as an immunotherapeutic strategy for osteosarcoma. We suggest that our proposed immunotherapy could be developed further to improve osteosarcoma treatment

  10. Th9 cells and iTregs are developmentally linked and GITR can subvert tolerogenic conditions to boost Th9 immunity.

  11. GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells.

  12. enhanced GITR-triggering mediates its protective, anti-viral effect on the CD8 T cell compartment by boosting CD4 T cell help.

  13. A CD4 T cell-intrinsic role for GITR in sustaining early CD8 and late humoral responses to collectively promote control of chronic LCMV clone 13 infection.

  14. GITRL expressed on macrophages drives cytokine release and T cell activation, resulting in neuropathic pain via GITR-dependent actions. The GITRL-GITR pathway might represent a novel target for the treatment of neuropathic pain.

  15. Data show that GITR agonist antibody alters Treg lineage stability inducing an inflammatory effector T cell phenotype. The resultant loss of lineage stability causes Treg to lose their intra-tumor immune suppressive function.

  16. Gene expression in the Gitr locus is regulated by NF-kappaB and Foxp3 through an enhancer.

  17. Inhibition of GITR decreases leukocyte cell adhesion.

  18. The effects of GITR activation on Treg cells can have different outcomes depending on the experimental context ranging from expansion in normal mice to death in the Inflammatory bowel disease model.

  19. GITR triggering on CD4(+)T cells increases poststroke inflammation and decreases the number of neural stem/progenitor cells induced by ischemia (iNSPCs).

  20. these data suggest that GITR plays a role in the survival of CD8 memory phenotype T cells

Human Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) Interaktionspartner

  1. HTLV-1 infection can modify the expression of main functional transcription factors, FOXP3 and GITR

  2. a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner

  3. Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients.

  4. GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB activation.

  5. GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells.

  6. Data may suggest a key role of regulatory GITR+CD25 low/-CD4+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients.

  7. results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP.

  8. these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg) cells, suggesting that GITR is a T(reg)-cell marker that would be primarily involved in T(reg)-cell survival rather than in their suppressor function.

  9. Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS.

  10. GITR acts as a potential tumor suppressor in MM.

  11. Data indicate that the mRNAs of CTLA-4 and GITR genes were expressed at lower levels in CVID patients compared to control group.

  12. GITR is pathologically expressed on Treg cells in systemic lupus erythematosus.

  13. Liver tumor Tregs up-regulate the expression of glucocorticoid-induced tumor necrosis factor receptor compared with Tregs in tumor-free liver tissue and blood.

  14. Results suggest that GITR expression might indicate a molecular link between steroid use and complicated acute sigmoid diverticulitis. Increased MMP-9 expression by GITR signalling might explain morphological changes in the colonic wall in diverticulitis.

  15. The regulatory SNPs identified in this study will provide useful information for understanding the relevance of sequence polymorphisms in populations of different background and may serve as a basis to study parasite susceptibility in association studies

  16. GITRL may contribute to disease pathophysiology and resistance to direct and Rituximab-induced NK reactivity in CLL

  17. GITR, which transmits a signal that abrogates regulatory T cell functions, was elevated in early rheumatoid arthritis.

  18. DCs transfected with mRNA encoding a humanized anti-CTLA-4 mAb and mRNA encoding a soluble human GITR fusion protein enhance the induction of anti-tumor CTLs in response to DCs.

  19. Findings suggest that GITR-expression of TILs is associated with cancer progression.

  20. Although GITR transgene costimulation can therapeutically enhance T helper (Th) type 2 cell responses, GITR-GITR ligand interactions are not required for development of Th2-mediated resistance or pathology.

TNFRSF18 Protein Überblick

Protein Überblick

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Genbezeichner und Symbole assoziert mit TNFRSF18

  • TNF receptor superfamily member 18 (TNFRSF18)
  • tumor necrosis factor receptor superfamily, member 18 (Tnfrsf18)
  • TNF receptor superfamily member 18 (Tnfrsf18)
  • AITR Protein
  • CD357 Protein
  • Gitr Protein
  • GITR-D Protein
  • TNFRSF18 Protein

Bezeichner auf Proteinebene für TNFRSF18

tumor necrosis factor receptor superfamily member 18 , glucocorticoid-induced TNFR-related , tumor necrosis factor receptor superfamily, member 18 , glucocorticoid-induced TNFR-related protein , TNF receptor superfamily activation-inducible protein , activation-inducible TNFR family receptor

419424 Gallus gallus
516256 Bos taurus
606971 Canis lupus familiaris
699559 Macaca mulatta
741567 Pan troglodytes
21936 Mus musculus
8784 Homo sapiens
500598 Rattus norvegicus
Ausgewählte Anbieter für TNFRSF18 Proteine (TNFRSF18)
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