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The protein encoded by TNFRSF17 is a member of the TNF-receptor superfamily. Zusätzlich bieten wir Ihnen TNFRSF17 Antikörper (127) und TNFRSF17 Proteine (52) und viele weitere Produktgruppen zu diesem Protein an.
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soluble BCMA sequesters circulating BAFF (zeige TNFSF13B ELISA Kits), thereby preventing it from performing its signaling to stimulate normal B-cell and plasma cell development, resulting in reduced polyclonal antibody levels in multiple myeloma patients.
Studied expression of B-cell maturation antigen (BCMA) in osteoblasts and the toxic effect of chromium on its expression; found BCMA is involved in osteogenesis of osteoblasts; chromium downregulates expression of BCMA in osteoblasts.
BCMA has other contributors for ligands binding except DxL motif. The affinity of BCMA for APRIL higher than for BAFF (zeige TNFSF13B ELISA Kits) may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM.
We have identified a specific serum protein, BCMA, as a novel independent marker for both monitoring and predicting outcomes for MM patients. We have shown that sBCMA is elevated in MM patients, and can be used to follow their disease status, PFS and OS.
The expression levels of serum BAFF (zeige TNFSF13B ELISA Kits) and the three receptors (TACI (zeige TNFRSF13B ELISA Kits), BCMA and BAFF-R (zeige TNFRSF13C ELISA Kits)) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls.
Decreased BCMA expression on peripheral B cells according to severe disease activity suggests that BCMA plays an important regulating role in B-cell hyperactivity and immune tolerance homeostasis in systemic lupus erythematosus patients
results suggest that Akt (zeige AKT1 ELISA Kits) and JNK (zeige MAPK8 ELISA Kits) pathways are involved in the regulation of B-cell maturation antigen (BCMA)
shedding of BCMA by gamma-secretase controls plasma cells in the bone marrow and yields a potential biomarker for B-cell involvement in human autoimmune diseases
Data show significant differences in expression of tumour necrosis factor family (BAFF (zeige TNFSF13B ELISA Kits)) receptors BAFF-R (zeige TNFRSF13C ELISA Kits), BCMA and TACI (zeige TNFRSF13B ELISA Kits) in patients with and without anti-Jo-1 or anti-Ro52 (zeige TRIM21 ELISA Kits)/anti-Ro60 (zeige TROVE2 ELISA Kits) autoantibodies.
high affinity antibody blocks the binding of the native ligands APRIL and BAFF (zeige TNFSF13B ELISA Kits) to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA
Elimination of B lymphocyte stimulator (zeige TNFSF13B ELISA Kits) receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice.
we have identified a novel role for BCMA to control excess BAFF (zeige TNFSF13B ELISA Kits) production in murine lupus through restraining the accumulation of BAFF (zeige TNFSF13B ELISA Kits)-producing neutrophils.
Heteromers consisting of one BAFF (zeige TNFSF13B ELISA Kits) and two APRIL bind to receptor TACI (zeige TNFRSF13B ELISA Kits), BCMA but not to BAFFR (zeige TNFRSF13C ELISA Kits).
BCMA is dispensable for the development of SLE in NZM mice. BAFF (zeige TNFSF13B ELISA Kits)-BCMA interactions contribute to SLE.
Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity.
Blimp-1 (zeige PRDM1 ELISA Kits) is a positive regulator of the expression of BCMA gene in mouse plasma cells.
The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity.
A vital role of BCMA in bone marrow plasma cell survival.
B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
tumor necrosis factor receptor superfamily member 17
, tumor necrosis factor receptor superfamily, member 17
, B cell maturation antigen
, B-cell maturation factor
, B-cell maturation protein