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Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Zusätzlich bieten wir Ihnen TBCC Proteine (9) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal TBCC Primary Antibody für IF, ELISA - ABIN520721
Hage-Sleiman, Herveau, Matera, Laurier, Dumontet: Silencing of tubulin binding cofactor C modifies microtubule dynamics and cell cycle distribution and enhances sensitivity to gemcitabine in breast cancer cells. in Molecular cancer therapeutics 2011
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a testable model for TBCC N-terminal domain/tubulin recognition in which the highly charged N-terminus as well as residues from the three helices and the loops interact with the acidic hypervariable regions of tubulin monomers
Microtubule dynamicity was reduced in breast cancer cells overexpressing TBCC. Cell cycle distribution was altered in cells containing larger amounts of TBCC. TBCC had little effect on cell proliferation.
functional overlap with retinitis pigmenosa 2 protein
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex\; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
tubulin-folding cofactor C
, tubulin-specific chaperone C
, beta-tubulin cofactor C