anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Antikörper

The protein encoded by TRPC6 forms a receptor-activated calcium channel in the cell membrane. Zusätzlich bieten wir Ihnen Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Proteine (8) und Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TRPC6 7225 Q9Y210
TRPC6 22068 Q61143
TRPC6 89823  
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Top anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Antikörper auf antikoerper-online.de

Showing 10 out of 134 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Pferd Kaninchen Unkonjugiert WB WB Suggested Anti-TRPC6 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: MCF7 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TRPC6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  MCF7 cell lysate TRPC6 antibody - middle region  validated by WB using pulmonary artery smooth muscle 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-TRPC6 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti-TRPC6 antibody, Western blotting Lane 1: Rat Lung Tissue Lysate Lane 2: 293T Cell Lysate Lane 3: 293T Cell Lysate 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Pferd Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-TRPC6 Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate Human kidney 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Ziege Unkonjugiert ELISA, WB ABIN334518 (0.03 ug/ml) staining of Human Placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Maus Kaninchen Unkonjugiert WB Western blot analysis of TRPC6 using anti-TRPC6 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat ovary tissue lysate, Lane 2: mouse lung tissue lysate.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TRPC6 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for TRPC6 at approximately 106KD. The expected band size for TRPC6 is at 106KD. 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Ziege Unkonjugiert IP, ELISA, WB Western Blot: TRPC6 Antibody [NBP1-00142] - Analysis of TRPC6 in human placenta lysate (35ug protein in RIPA buffer) using this antibody at 0.03 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Maus Unkonjugiert IHC, ELISA, WB Western Blot of Mouse anti-TRPC6 Antibody Lane 1: Mouse Kidney WCL Load: 10 µg per lane Primary antibody: TRPC6 Antibody at 1:1000 for overnight at 4°C Secondary antibody: 649 donkey anti-mouse at 1:20,000 for 30 min at RT Block: ABIN925618 for 30 min at RT Immunohistochemistry using  anti-TRPC6 monoclonal antibody shows detection of TRPC6 in human adrenal (cortex) tissue (40X). The antibody was used a dilution to 2.5 µg/mL. The image shows strong staining with minimal background staining. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. Personal communication, Andrew Elston, Lifespan Biosciences, Seattle, WA. 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$389.00
Details
Maus Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Kaninchen Unkonjugiert WB WB Image A549 whole cell and membrane extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with TRPC6 antibody , diluted at 1:3000. WB Image Sample(30 μg of whole cell lysate) A:HeLa S3, 7.5% SDS PAGE antibody diluted at 1:3000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details

Am meisten referenzierte anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Antikörper

  1. Human Polyclonal TRPC6 Primary Antibody für IP, ELISA - ABIN314245 : Foller, Kasinathan, Koka, Lang, Shumilina, Birnbaumer, Lang, Huber: TRPC6 contributes to the Ca(2+) leak of human erythrocytes. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2008 (PubMed)
    Show all 4 Pubmed References

  2. Mouse (Murine) Polyclonal TRPC6 Primary Antibody für FACS, ELISA - ABIN269792 : Winn, Conlon, Lynn, Farrington, Creazzo, Hawkins, Daskalakis, Kwan, Ebersviller, Burchette, Pericak-Vance, Howell, Vance, Rosenberg: A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. in Science (New York, N.Y.) 2005 (PubMed)

Weitere Antikörper gegen Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Interaktionspartner

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Interaktionspartner

  1. Reduction of TRPC6 activity, using either TRPC6 siRNA or a TRPC6 blocker, led to inhibition of hypoxia-induced autophagy, while enhancement of TRPC6 activity with a TRPC6 activator resulted in increased hypoxia-induced autophagy.

  2. axonal colocalization of TRPV4 (zeige TRPV4 Antikörper) and TRPC6 was found in the digital Meissner corpuscles

  3. Data suggest that TRPC6-mediated elevation of intracellular Ca2 (zeige CA2 Antikörper)+ stimulates non-small cell lung cancer proliferation by promoting cell cycle progression.

  4. potential implications of transient receptor potential (TRP) channels in the pathogenesis of intestinal fibrosis, since they are known to act as cellular stress sensors/transducers affecting intracellular Ca(2 (zeige CA2 Antikörper)+) homeostasis/dynamics, and are involved in a broad spectrum of cell pathophysiology including inflammation and tissue remodeling.

  5. Studies provide evidence that the TRPC6-mediated signaling pathway in kidney cells is under control of reactive oxygen species under both physiological and pathological conditions. [review]

  6. SARAF (zeige TMEM66 Antikörper) modulates TRPC1 (zeige TRPC1 Antikörper), but not TRPC6, channel function in a STIM1 (zeige STIM1 Antikörper)-independent manner

  7. Functional interaction of upregulated CaSR (zeige CASR Antikörper) and upregulated TRPC6 in pulmonary artery smooth muscle cells from idiopathic pulmonary arterial hypertension patients may play an important role in the development and progression of sustained pulmonary vasoconstriction and pulmonary vascular remodeling.

  8. Our comprehensive analysis of human disease-causing TRPC6 mutations reveals loss of TRPC6 function as an additional concept of hereditary focal segmental glomerulosclerosis and provides molecular insights into the mechanism responsible for the loss-of-function phenotype of TRPC6 G757D in humans

  9. study demonstrated that the various mechanisms regulating MDR in HCC (zeige FAM126A Antikörper) cells are calcium dependent through the TRPC6/calcium/STAT3 (zeige STAT3 Antikörper) pathway. We propose that targeting TRPC6 in HCC (zeige FAM126A Antikörper) may be a novel antineoplastic strategy, especially combined with chemotherapy

  10. n response to stretching (20%), ATP was released only from the foremost cells at the wound edge; it then diffused to the cells behind the wound edge and activated the P2Y (zeige P2RY1 Antikörper) receptors, which caused propagating Ca(2 (zeige CA2 Antikörper)+) waves via TRPC6

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Interaktionspartner

  1. We conclude that TRPC6 channels of pancreatic stellate cells are major effector proteins in an autocrine stimulation pathway triggered by hypoxia.

  2. findings link Trpc6-mediated Ca2 (zeige CA2 Antikörper)+ signaling and nitrosative stress in the redox pathobiology of Duchenne muscular dystrophy (zeige DMD Antikörper)

  3. The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death. We identify canonical transient receptor potential channels (TRPC) 3/6/7 as the cation channels through which most of the damaging calcium enters cells to trigger their death, and we describe mechanisms activated during the injury phase.

  4. Administration of soluble klotho (zeige KL Antikörper) significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 knockout mice, indicating that klotho (zeige KL Antikörper) and TRPC6 inhibition act in the same pathway to protect against obstruction-induced renal fibrosis.

  5. In the present study, we have explored the hypothesis that TRPC3 (zeige TRPC3 Antikörper) and TRPC6 channels expressed in VSMCs may have a differential contribution to the regulation of vascular tone, which could be relevant for the changes in vascular reactivity associated with essential hypertension

  6. This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 (zeige ORAI2 Antikörper) form stromal interaction molecule 2 (STIM2 (zeige Stim2 Antikörper))-regulated neuronal-store-operated Ca(2 (zeige CA2 Antikörper)+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2 (zeige CA2 Antikörper)+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons.

  7. ASIV may prevent HG-induced podocyte apoptosis via downregulation of TRPC6, which is possibly mediated via the calcineurin/NFAT (zeige NFATC1 Antikörper) signaling pathway.

  8. the mTORC2 (zeige CRTC2 Antikörper)/Akt (zeige AKT1 Antikörper)/NFkappaB pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis.

  9. AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII.

  10. TRPC3 (zeige TRPC3 Antikörper) and TRPC6 participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

Cow (Bovine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Interaktionspartner

  1. These findings suggest that lysoPC induces CaM (zeige KRIT1 Antikörper) phosphorylation at Tyr (zeige TYR Antikörper)(99) by a Src (zeige SRC Antikörper) family kinase and that phosphorylated CaM (zeige KRIT1 Antikörper) activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane.

  2. analysis of a TRPC6-TRPC5 (zeige TRPC5 Antikörper) channel cascade that restricts endothelial cell movement

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Interaktionspartner

  1. Hyperforin (HF)-induced TRPC6 channel activation increased [Ca(2 (zeige CA2 Antikörper)+)]i concentration, inhibited proliferation, and triggered apoptosis in primary neonatal pig glomerular mesangial cells. This apoptosis was not associated with oxidative stress. Activation stimulated NFATc1 (zeige NFATC1 Antikörper) nuclear translocation. HF also increased FasL (zeige FASL Antikörper) level and caspase-8 (zeige CASP8 Antikörper) activity.

  2. Data found that the pig adrenal medulla expressed predominantly TRPC1 (zeige TRPC1 Antikörper), TRPC5 (zeige TRPC5 Antikörper), and TRPC6 transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.

Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Antigen-Profil

Protein Überblick

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Genbezeichner und Symbole assoziert mit TRPC6

  • transient receptor potential cation channel subfamily C member 6 (TRPC6) Antikörper
  • transient receptor potential cation channel, subfamily C, member 6 (Trpc6) Antikörper
  • transient receptor potential cation channel, subfamily C, member 6a (trpc6a) Antikörper
  • transient receptor potential cation channel subfamily C member 6 (Trpc6) Antikörper
  • transient receptor potential cation channel subfamily C member 6 (trpc6) Antikörper
  • AV025995 Antikörper
  • bZ1P14.9 Antikörper
  • FSGS2 Antikörper
  • LLHWJM002 Antikörper
  • LLHWJM003 Antikörper
  • LLHWJM004 Antikörper
  • mtrp6 Antikörper
  • si:rp71-1p14.9 Antikörper
  • TRP-6 Antikörper
  • trp6 Antikörper
  • trpc6 Antikörper
  • Trrp6 Antikörper

Bezeichner auf Proteinebene für TRPC6

TRP-6 , short transient receptor potential channel 6 , transient receptor protein 6 , calcium entry channel , transient receptor potential cation channel, subfamily C, member 6 , transient receptor potential channel subfamily C member 6 , short transient receptor potential channel 6-like

GENE ID SPEZIES
7225 Homo sapiens
22068 Mus musculus
89823 Rattus norvegicus
407151 Bos taurus
418989 Gallus gallus
451503 Pan troglodytes
489435 Canis lupus familiaris
563989 Danio rerio
100061175 Equus caballus
100079408 Ornithorhynchus anatinus
100135637 Cavia porcellus
100271728 Sus scrofa
100347206 Oryctolagus cuniculus
100395510 Callithrix jacchus
100479387 Ailuropoda melanoleuca
100545253 Meleagris gallopavo
100554810 Anolis carolinensis
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