TRPC6 Antikörper (Middle Region)

Produktnummer ABIN3044146

Produktdetails anti-TRPC6 Antikörper

Target: TRPC6 (Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6))

Bindungsspezifität: AA 249-265, Middle Region

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRPC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Short transient receptor potential channel 6(TRPC6) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: HDYFCKCNDC NQKQKHD

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Short transient receptor potential channel 6(TRPC6) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: transient receptor potential cation channel, subfamily C, member 6
Protein Name: Short transient receptor potential channel 6(TrpC6)

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TRPC6(249-265aa HDYFCKCNDCNQKQKHD), different from the related rat and mouse sequences by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-TRPC6 Antikörper (ABIN3044146)

Wang, Wang, Li: "TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells." in: Oncotarget, Vol. 7, Issue 32, pp. 50937-50951, (2018) (PubMed).

Details zu TRPC6

Target: TRPC6 (Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6))

Andere Bezeichnung: TRPC6 (TRPC6 Produkte)

Synonyme: FSGS2 antikoerper, TRP6 antikoerper, AV025995 antikoerper, LLHWJM002 antikoerper, LLHWJM003 antikoerper, LLHWJM004 antikoerper, TRP-6 antikoerper, Trrp6 antikoerper, mtrp6 antikoerper, trp6 antikoerper, bZ1P14.9 antikoerper, si:rp71-1p14.9 antikoerper, trpc6 antikoerper, transient receptor potential cation channel subfamily C member 6 antikoerper, transient receptor potential cation channel, subfamily C, member 6 antikoerper, transient receptor potential cation channel, subfamily C, member 6a antikoerper, TRPC6 antikoerper, Trpc6 antikoerper, trpc6a antikoerper, trpc6 antikoerper

Hintergrund: Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Synonyms: bZ1P14.9 antibody|FLJ11098 antibody|FLJ14863 antibody|FSGS2 antibody|MTRP6 antibody|Short transient receptor potential channel 6 antibody|si:rp71-1p14.9 antibody|Transient Receptor Potential Cation Channel Subfamily C Member 6 antibody|Transient receptor protein 6 antibody|TRP 6 antibody|TRP-6 antibody|TRP6 antibody|TRPC 6 antibody|TrpC6 antibody|Trpc6 antibody|TRPC6_HUMAN antibody|TRRP6 antibody

UniProt: Q9Y210