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We suggest that TGFBR3 protein expression is involved in up-regulated TGF-beta signaling in Marfan syndrome patients with a dominant negative FBN1 gene mutation.
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describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells
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TGF-beta type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin was increased in both subtypes.
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TGFBR3 and/or MGEA5 rearrangements are much more common in hybrid hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas.
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opposing functions for the different GAG modifications on TbetaRIII suggesting that Wnt interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt signaling, likely via Wnt sequestration, whereas the chondroitin sulfate GAG chains on TbetaRIII promote Wnt3a signaling.
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Results suggest that high expression levels of alpha-inhibin and beta-glycan transcripts in secretory phase endometrium are associated with a lower chance of achieving pregnancy with in vitro fertilization.
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Results show decreased TbetaRIII expression with hepatocellullar carcinoma (HCC) progression leading to the activation of Smad2 and suggest that TbetaRIII acts as a suppressive factor in regulating the migration and invasion of HCC, by inhibiting Smad2 and Akt pathways.
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Study shows that TbetaRIII expression is significantly decreased in salivary glands adenoid cystic carcinoma (ACC) patients and defines TbetaRIII as a biomarker exerting antitumor action on ACC progression.
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No correlation of loss of heterozygosity at the TGFBR3 locus with clinicopathological parameters suggests that allelic imbalance may be an early genetic event during neoplastic transformation of human endometrium.
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Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition.
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Data suggest a high potential of plasma sTBFbetarIII as a novel diagnostic and prognostic biomarker in breast cancer.
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rs1192415 of TGFBR3 is associated with primary open angle glaucoma.
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results suggest overexpression of TbetaRIII receptor restored TGF-beta1 sensitivity in CAL-27 cells
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The presence of the index SNP rs1192415 (TGFBR3-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients.
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Inhibiting ectodomain shedding of TbetaRIII increased TGF-beta responsiveness and abrogated TbetaRIII's ability to inhibit breast cancer cell migration and invasion.
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RS1805110 is not associated with Behcet's disease or idiopathic intermediate uveitis in Caucasian patients.
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data suggest complex or phenotype specific association of cryptorchidism with TGFBR3 and the gubernaculum as a potential target of TGFbeta signaling
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We have found that TbetaRIII is required for migration and invasion in vitro and xenograft growth in vivo.
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Data indicate that TGF-beta2 (TGFB2) and TGF beta type III receptor (TGFBR3) are target genes of miR-193b in chondrogenesis.
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These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells.
