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Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. Zusätzlich bieten wir Ihnen Transaldolase 1 Proteine (68) und Transaldolase 1 Kits (15) und viele weitere Produktgruppen zu diesem Protein an.
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The above findings support the premise that biallelic mutations in TALDO1 are responsible for transaldolase deficiency and confirm the broad phenotypic variability of this condition, even with the same genotype.
This study expands the clinical definition of transaldolase deficiency, and adds to its allelic heterogeneity.
Data suggest that exchange reactions during gluconeogenesis catalyzed by transaldolase and triose-phosphate isomerase (zeige TPI1 Antikörper) do not differ between subjects with type 2 diabetes and control subjects under fasting or hyperglycemic conditions.
renal phenotype of patients with transaldolase deficiency
these data provide strong experimental evidence that transaldolase exchange occurs in humans, resulting in an overestimate of gluconeogenesis
granzyme B (zeige Gzmb Antikörper)-cleaved transaldolase-specific T cell-mediated cytotoxicity may contribute to the progressive destruction of oligodendrocytes in patients with multiple sclerosis
transaldolase is regulated by ZNF143 (zeige ZNF143 Antikörper) in a tissue-specific manner
Mutation in the TALDO1 gene was found in patients with hydrops fetalis and neonatal multi-organ disease.
Transaldolase-deficient patients had significantly increased urinary heptoses, revealing novel urinary biomarkers for identification of the deficiency.
The present study identified the TAL deficiency as a modulator of mitochondrial homoeostasis, Ca(2 (zeige CA2 Antikörper)+) fluxing and apoptosis.
These data reveal an essential role of transaldolase in sperm-cell mitochondrial function and, thus, male fertility.
Reduced beta-catenin (zeige CTNNB1 Antikörper) phosphorylation and enhanced c-Jun (zeige JUN Antikörper) expression in Taldo1-/- livers reflected adaptation to oxidative stress
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
, glycerone transferase
, EPS8-like 2
, transaldolase 1
, Transaldolase 1