anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) Antikörper

Mouse (Murine) Topoisomerase (DNA) II beta 180kDa (TOP2B) Interaktionspartner

1. We demonstrated that Nup98 (zeige NUP98 Antikörper)-TopIIbeta and Nup98 (zeige NUP98 Antikörper)-SETBP1 (zeige SETBP1 Antikörper) negatively regulate the XPO1 (zeige XPO1 Antikörper)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (zeige NUP98 Antikörper)-fusion proteins induce tumorigenesis.

2. TOP2beta as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

3. Results identified topoisomerase IIbeta (Top2beta) as a novel determinant for camptothecin sensitivity.

4. Top IIbeta might be a down-stream target of Nurr1 (zeige NR4A2 Antikörper), which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression.

5. Findings suggest a chromatin-based targeting of Top2beta to regulatory regions in the genome to govern the transcriptional program associated with neuronal differentiation and longevity.

6. Data suggest that activity of TOP2B in elongating spermatids is strongly inhibited by PARP1 (zeige PARP1 Antikörper) and PARP2 (zeige PARP2 Antikörper), and this is in turn counteracted by the PAR (zeige AFG3L2 Antikörper)-degrading activity of PAR (zeige AFG3L2 Antikörper) glycohydrolase.

7. proteasomal degradation of TOP2beta induced by the TOP2-DNA covalent complex or the TOP2 circular clamp is due to transcriptional arrest but not DNA damage

8. DNA topoisomerase II beta deficiency severely affects cerebral cortex stratification: no subplate is discernible, and neurons born at later stages of corticogenesis fail to migrate to the superficial layers.

9. A nuclear matrix-associated (zeige SMARCA5 Antikörper) topoisomerase IIB (TOP2B) interacting with an extracellular Mn2+/Ca2 (zeige CA2 Antikörper)+-dependent nuclease (zeige DCLRE1C Antikörper) cleaves sperm DNA into loop-sized fragments.

10. These results suggest that the defect in establishing neuromuscular junctions in top2beta knockout mice could be due to the lack of TopIIbeta-mediated neurite outgrowth.

Human Topoisomerase (DNA) II beta 180kDa (TOP2B) Interaktionspartner

1. The article discusses origin of topoisomerase II beta, its structure, activities reported in vitro and in vivo along with implications in cellular processes namely transcription, DNA repair, neuronal development, aging, HIV-infection and cancer. (Review)

2. recent data point to a critical role of topoisomerase II beta (TOP2B), which is a primary target of anthracycline poisoning, in the pathophysiology of anthracycline-induced congestive heart failure .

3. The decatenation checkpoint is regulated, not only by topo IIalpha, as previously reported, but also by topo IIbeta. The decatenation checkpoint is most efficient when both isoforms are present. Deletion of most of the C-terminus of topo IIbeta, while preserving the nuclear localization signal, and mutation of Y656 in topo IIbeta inhibits the decatenation checkpoint and sensitivity to topo II (zeige TOP2 Antikörper)-targeted drugs.

4. TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.

5. Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II (zeige TOP2 Antikörper) positivity were strong predictors for preoperative epileptic seizures.

6. during early development, TOP2A (zeige TOP2A Antikörper) is likely to have a role in cell proliferation, whereas TOP2B is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.

7. Cinobufacini inhibited the proliferation of the HepG-2 cells induced apoptosis in a dose- and time-dependent manner and downregulated the mRNA and protein expression levels of TOPO I (zeige TOP1 Antikörper) and TOPO II (zeige TOP2 Antikörper)

8. A direct interaction between Ku70 (zeige XRCC6 Antikörper)/86 and BRG1 (zeige SMARCA4 Antikörper) brings together SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) remodeling capabilities and TOP2beta activity to enhance the transcriptional response to hormone stimulation.

9. Human cytomegalovirus IE1 exon 4 interacts with Topoisomerase IIbeta (TOPOIIbeta), whose activity is required for viral genome persistence and maintenance via binding to a cis (zeige CISH Antikörper)-acting viral maintenance element.

10. Proteolytic degradation of Top2 (zeige TOP2A Antikörper) enables the processing of Top2 (zeige TOP2A Antikörper).DNA and Top2 (zeige TOP2A Antikörper).RNA covalent complexes by TDP2 (zeige TDP2 Antikörper).