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TOP1MT encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. Zusätzlich bieten wir Ihnen TOP1MT Proteine (6) und und viele weitere Produktgruppen zu diesem Protein an.
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Study demonstrated that lack of TOP1MT results in delayed and decreased tumor growth due to impaired mitochondrial translation. The TOP1MT genomic signature profile, based on mouse model for Top1mt-KO liver cancers, is correlated with enhanced survival of hepatocellular carcinoma patients.
TOP1MT acts as a topological barrier and regulator for mtDNA transcription and D-loop formation
This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells.
Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I inhibitors.
DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid.
Data reported in this paper indicate that hTop IB does not confer to the cells radio-resistance, but the kinetic analysis of both DNA repair rate as well as colonies growth, demonstrates that the cells containing hTop IB show a more efficient rescue from IR injury.
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
DNA topoisomerase I, mitochondrial
, mitochondrial topoisomerase I
, mitochondrial topoisomerase IB
, DNA topoisomerase 1, mitochondrial