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TOP1MT encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology.
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TOP1MT acts as a topological barrier and regulator for mtDNA transcription and D-loop formation
This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells.
Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I (zeige TOP1 Antikörper) inhibitors.
DNA topoisomerase I (zeige TOP1 Antikörper) stimulates BLM helicase (zeige BLM Antikörper) activity on a nucleolar-relevant RNA:DNA hybrid.
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
DNA topoisomerase I, mitochondrial
, mitochondrial topoisomerase I
, mitochondrial topoisomerase IB
, DNA topoisomerase 1, mitochondrial