Tight Junction Protein 2 (Zona Occludens 2) (TJP2) ELISA Kits

TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Zusätzlich bieten wir Ihnen TJP2 Antikörper (111) und TJP2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
TJP2 9414 Q9UDY2
Anti-Maus TJP2 TJP2 21873 Q9Z0U1
Anti-Ratte TJP2 TJP2 115769  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 4.68 pg/mL 18.75-1200 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
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Weitere ELISA Kits für TJP2 Interaktionspartner

Human Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaktionspartner

  1. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS

  2. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39

  3. Patients with a confirmed ABCB11 or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 mutation had an elevated THBA proportion (7.51-37.26%).

  4. Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.

  5. Data identified two Disease-causing Genes TJP2 and GJB2 (zeige GJB2 ELISA Kits) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.

  6. TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood

  7. Claudin-19 (zeige CLDN19 ELISA Kits), the most abundant claudin in myelin, exhibited no binding to ZO2.

  8. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton.

  9. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.

  10. demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (zeige MMP14 ELISA Kits)

Mouse (Murine) Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaktionspartner

  1. Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 genes accelerated the defects observed in ZO-1 (zeige TJP1 ELISA Kits) knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1 (zeige TJP1 ELISA Kits)-dependent regulation of podocyte filtration barrier.

  2. In the present study, we found that the protein level of ZO-2, a scaffolding tight junction protein (zeige OCLN ELISA Kits), decreased in the bladder of OVX mice indicating a possible role in overactive bladder.

  3. Expression of Podocalyxin (zeige PODXL ELISA Kits), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (zeige EZR ELISA Kits).

  4. SNX27 associates with ZO-2 and modulates the epithelial tight junction.

  5. ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway

  6. the first PDZ domain of ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; these activities of ZO-2 are PDZ-domain-dependent

  7. Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.

  8. nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions

  9. ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical

  10. These findings indicate that ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 can independently determine whether and where claudins are polymerized.

Zebrafish Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaktionspartner

  1. analysis of tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio

TJP2 Antigen-Profil

Beschreibung des Gens

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit TJP2

  • tight junction protein 2 (TJP2) Antikörper
  • tight junction protein 2 (Tjp2) Antikörper
  • tight junction protein 2 L homeolog (tjp2.L) Antikörper
  • tight junction protein 2b (zona occludens 2) (tjp2b) Antikörper
  • C9DUPq21.11 Antikörper
  • DFNA51 Antikörper
  • DUP9q21.11 Antikörper
  • tjp2 Antikörper
  • wu:fb62b09 Antikörper
  • x104 Antikörper
  • zgc:92094 Antikörper
  • zo-2 Antikörper
  • zo2 Antikörper

Bezeichner auf Proteinebene für TJP2

Friedreich ataxia region gene X104 (tight junction protein ZO-2) , tight junction protein ZO-2 , zona occludens 2 , zonula occludens protein 2 , tight junction protein 2 (zona occludens 2) , Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2) , zona occludens protein 2 , tight junction protein 2 L homeolog , fb62b09 , tight junction protein 2b , tjp2.2 , zo-2.2

GENE ID SPEZIES
9414 Homo sapiens
100229218 Taeniopygia guttata
21873 Mus musculus
115769 Rattus norvegicus
395751 Gallus gallus
403854 Canis lupus familiaris
407101 Bos taurus
100729549 Cavia porcellus
779228 Xenopus laevis
436639 Danio rerio
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