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catalyzes the transfer of the terminal phosphate of ATP to thymidine to form thymidine 5'-phosphate (dTMP) [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen Thymidine Kinase 1, Soluble Antikörper (78) und Thymidine Kinase 1, Soluble Kits (34) und viele weitere Produktgruppen zu diesem Protein an.
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The down-regulation of Tk1 activity unmasks Tk2 deficiency in Tk2-/- mice and correlates with the onset of mtDNA depletion in the brain and the heart.
blood cells are less dependent on mitochondrial Tk2 compared with several other tissues; these cells can synthesize deoxyribonucleotides required for mtDNA replication by alternative pathways such as phosphorylation of thymidine by cytosolic Tk1
Mutations in the TK1 gene were studied in neonatal transgenic mice treated with AZT.
the small colony mutant phenotype in L5178Y lymphoma is not caused by deletion of both Trp53 (zeige TP53 Proteine) and thymidine kinase 1
Data suggest that serum thymidine kinase 1 (S-TK) activity may be a useful parameter for monitoring neoadjuvant therapy (nTx) efficacy.
Our study provides the first evidence that serum TK1 activity as early as 2 weeks following CDK4/6 (zeige CDK4 Proteine) inhibitors is highly correlated with tumor cell proliferation response in patients with early-stage HR+ breast cancer.
TK1 might be involved in the development and progression of PDAC by regulating cell proliferation.
The detection of TK1 combined with that cytokeratin-19 (zeige KRT19 Proteine) fragment (CYFRA21-1), CEA (zeige CEACAM5 Proteine) or NSE (zeige ENO2 Proteine) increased the diagnostic value of TK1 for lung squamous cell carcinoma, adenocarcinoma and small cell lung cancer, respectively.
The results have implications for the mechanism by which Fhit regulates TK1 mRNA, and more broadly, for its modulation of multiple functions as tumor suppressor/genome caretaker.
Results suggest that positive expression of CK19 (zeige KRT19 Proteine) mRNA and TK1 protein is closely correlated with poor prognosis in advanced gastrointestinal cancer.
though TK1 expression was an independent prognostic factor for relapse, but not for survival, TK1 is a more informative expression than Ki-67 (zeige MKI67 Proteine) for LI, relapse and overall survival rates. Thus, when TK1 is combined with MDACC grading, pTNM staging and lymph node metastasis, IHC determination of TK1 expression may improve the overall prediction of prognosis in patients with ovarian cancer.
Data show that the median thymidine kinase (TK1) levels found in sera from breast cancer patients with T1 to T4 stage disease were 0.31, 0.46, 0.47, and 0.55 ng/ml, and these levels significantly differed from healthy controls.
STK1 (zeige CDK7 Proteine) is a reliable biomarker for discovering people with malignant tumors in cancer screening.
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma (zeige MOK Proteine) and Radiofrequency Ablation of Metastases to Lung and Liver
catalyzes the transfer of the terminal phosphate of ATP to thymidine to form thymidine 5'-phosphate (dTMP)
, thymidine kinase, cytosolic
, thymidine kinase 1, soluble
, thymidine kinase 1
, Thymidine kinase, cytosolic
, thymidine kinase
, thymidine kinase 1 soluble isoform
, thymidine kinase-1