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TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain.
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DeltaNp73 was abundantly expressed in the atopic dermatitis epidermis and increased the release of TSLP via NF-kappaB (zeige NFKB1 Proteine) activation.
this study shows that long form of thymic stromal lymphopoietin of keratinocytes is induced by protein allergens
we found that activation of the protease-activated receptor 1 (PAR1 (zeige F2R Proteine)) induced secretion of TSLP by the corneal stromal cells... we proposed that TSLP might function as the link between increased protease activity and inflammatory responses or itch sensation in the corneas
TSLP-HOTAIR axis also plays a protective role in low-density lipoprotein (ox-LDL)-induced Endothelial cells' injury.
The aim of this study was to determine the influence of human rhinovirus on the genes involved in airway remodeling and to examine the impact of TSLP and contribution of oxidative stress on airway remodeling in the context of HRV infection.
TSLP-induced phosphorylation of l-plastin (zeige LCP1 Proteine) is increased in atopic dermatitis and increases eosinophil migration.
a hit expansion exercise yielded additional active compounds that could be amenable to further optimization, providing an opportunity to dissociate TSLP inhibition from other non-desired activities. This study illustrates the potential of phenotypic drug discovery to complement target based approaches by providing new chemistry and biology leads
study found that among patients with atopic dermatitis (AD), common FLG (zeige FGFR1 Proteine) null mutations are associated with earlier AD onset in a dose-dependent manner, whereas TSLP rs1898671 appears unrelated to the timing of AD onset
lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8 (zeige IL8 Proteine). Notably, both genera also lowered the TSLP expression in stimulated Caco-2 cells, regardless of the diet regimen.
this review focuses on recent advances on the effects of TSLP on obstetrical and gynecological diseases, including pregnancy failure, endometriosis, and cervical cancer
the pathological mechanisms of particulate matter PM2.5 may be associated with allergic/steroidresistant airway inflammation, Tcell helper (Th)1 (zeige TH1L Proteine)/Th2 cytokine production and upregulation of TSLP expression in a murine model of allergic and steroid-resistant asthma.
These findings suggest miR (zeige MLXIP Proteine)-19b reduces airway remodeling, airway inflammation, and degree of oxidative stress by inhibiting Stat3 (zeige STAT3 Proteine) signaling through TSLP downregulation in a mouse asthma model.
Results suggest combinatorial mechanisms involved in the tissue-selective regulation of thymic stromal lymphopoietin (TSLP) transcription in epidermal keratinocytes and intestinal epithelial cell(s) (IEC).
these results suggest that TSLP-TSLPR (zeige CRLF2 Proteine) signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection
blockading the JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) pathway restrains inflammatory Th2 cell response induced by TSLP-DCs in allergic rhinitis.
study concludes that IL-33 (zeige IL33 Proteine) and TSLP are required for epithelial cell IL-25 (zeige IL25 Proteine) expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection
TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin (zeige CDH1 Proteine) in house dust mite (HDM (zeige HDAC3 Proteine))-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin (zeige CDH1 Proteine) and beta-catenin (zeige CTNNB1 Proteine) as well as phosphorylation(p)-AKT (zeige AKT1 Proteine) induced by HDM (zeige HDAC3 Proteine). In vitro, HDM (zeige HDAC3 Proteine) increased the expression of TSLP and E-cadherin (zeige CDH1 Proteine) dysfunction by PI3K/Akt (zeige AKT1 Proteine) signaling pathway.
this study shows that TSLP is a key target of Mi-2beta (zeige CHD4 Proteine) in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation
These data demonstrate that multiple pathogenic strains of RSV induce IL-13 (zeige IL13 Proteine)-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection.
the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
thymic stromal lymphopoietin
, thymic stromal lymphopoetin
, thymic stroma-derived lymphopoietin