Thymic Stromal Lymphopoietin Proteine (TSLP)

TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Zusätzlich bieten wir Ihnen Thymic Stromal Lymphopoietin Antikörper (129) und Thymic Stromal Lymphopoietin Kits (44) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TSLP 85480 Q969D9
TSLP 53603 Q9JIE6
TSLP 688621  
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Top Thymic Stromal Lymphopoietin Proteine auf antikoerper-online.de

Showing 10 out of 45 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Human Cells Maus His tag 10 μg 14 bis 16 Tage
$285.35
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg 1 bis 2 Tage
$638.00
Details
Escherichia coli (E. coli) Human His tag 100 μg 13 bis 16 Tage
$1,107.69
Details
Escherichia coli (E. coli) Human Unkonjugiert Validation with Western Blot 10 μg 4 bis 8 Tage
$319.00
Details
Wheat germ Human GST tag 2 μg 11 bis 12 Tage
$338.33
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg 2 bis 3 Tage
$1,035.00
Details
Human Cells Maus Fc Tag   50 μg 4 Days
$313.50
Details
Escherichia coli (E. coli) Ratte His tag 100 μg 15 bis 18 Tage
$672.00
Details

TSLP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) , ,
, ,
Rat (Rattus)

Weitere Proteine zu Thymic Stromal Lymphopoietin (TSLP) Interaktionspartnern

Human Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. This study revealed lower TSLP mRNA expression levels in vitiliginous skin than in normal skin suggesting an imminent role of TSLP in the pathogenesis of vitiligo.

  2. Our study illustrates that the TSLP/TSLPR axis might be involved in the pathogenesis of CAD through upregulation of mRNA or protein expression of the referenced genes and might have additive effects on the CAD risk when combined with IL-33 signaling.

  3. Low TSLP expression is associated with Ulcerative Colitis.

  4. It was verified that three SNPs (rs3806932, rs2289276 and rs2289278) are associated with susceptibility of atopic disease. We found three SNPs (rs3806932, rs3806933 and rs2289276) form one LD block; most especially, it is expected that the GTT haplotype strongly contributes to AM.

  5. Skin lesions from Behcet disease (BD) patients expressed high thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL-33) mRNA.

  6. TSLP might promote asthmatic airway remodeling via p38 MAPK-STAT3 axis activation and the crosstalk between airway epithelial cells and fibroblasts could aggravate remodeling.

  7. The data implicate TSLP and IL-33 in the pathogenesis of asthma that is characterized by persistent airway inflammation and impaired lung function despite intensive corticosteroid therapy, highlighting them as potential molecular targets.

  8. the findings of the present study revealed a novel mechanism of estrogendependent apoptotic suppression of Endometriosis (EMS)associated with TSLP secretion and Bcl2 regulation. Endogenous and estrogeninduced endometrial TSLP may promote the initiation and development of EMS via the inhibition of apoptosis

  9. this study shows that EMSY is increased and activates TSLP & CCL5 expression in eosinophilic esophagitis

  10. TSLP receptor allosterically activates TSLP to potentiate the recruitment of the shared interleukin 7 receptor alpha-chain (IL-7Ralpha) by leveraging the flexibility, conformational heterogeneity and electrostatics of the cytokine.

  11. Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells.

  12. presence of epithelium-derived TSLP in the eustachian tubes plays important role in the onset of eosinophilic otitis media

  13. a new mechanism of T cell stimulation in human skin was identified, demonstrating the direct induction of T cell migration by TSLP in the absence of DCs.

  14. the secretion of TSLP by keratinocytes is induced by the HIV-1 viral synapse in a miR-375 controlled manner

  15. production increased at skin sites of ovalbumin sensitization

  16. Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL-33 levels.

  17. short and long thymic stromal lymphopoietin isoforms have roles in house dust mite-induced asthmatic airway epithelial barrier disruption

  18. DeltaNp73 was abundantly expressed in the atopic dermatitis epidermis and increased the release of TSLP via NF-kappaB activation.

  19. this study shows that long form of thymic stromal lymphopoietin of keratinocytes is induced by protein allergens

  20. we found that activation of the protease-activated receptor 1 (PAR1) induced secretion of TSLP by the corneal stromal cells... we proposed that TSLP might function as the link between increased protease activity and inflammatory responses or itch sensation in the corneas

Mouse (Murine) Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. Our results suggest that the IL-33/ST2 pathway is important for eosinophilic inflammation but redundant for airway hyperreactivity and mucus production. The combined action of IL-33 and TSLP is essential for maintenance of airway hyperreactivity and goblet cell metaplasia during the chronic phase of experimental asthma.

  2. These findings indicate that physcion could ameliorate atopic dermatitis (AD)-like skin lesions by inhibiting TSLP levels via caspase-1/MAPKs/NF-kB signalings, which would provide experimental evidence of the therapeutic potential of physcion for AD.

  3. Prevention of food allergy development and suppression of established food allergy by neutralization of thymic stromal lymphopoietin, IL-25, and IL-33.

  4. Innate immunity-driven type 2 immune responses of the ocular surface are dependent on IL-33, TSLP, basophils, and ILC2. These components may be possible therapeutic targets for refractory allergic keratoconjunctivitis.

  5. this paper shows that IL-33 promotes gastrointestinal allergy in a TSLP-independent manner

  6. a new pathway for the activation of Treg involving in tumor-derived HMGB1 and TSLP, and have important implications for incorporating HMGB1 inhibitors into cancer immunotherapy.

  7. Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells.

  8. findings suggest a role of TSLP in directly promoting Th2 cell effector function and support the notion of TSLP as a key driver of Th2

  9. Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis.

  10. the pathological mechanisms of particulate matter PM2.5 may be associated with allergic/steroidresistant airway inflammation, Tcell helper (Th)1/Th2 cytokine production and upregulation of TSLP expression in a murine model of allergic and steroid-resistant asthma.

  11. These findings suggest miR-19b reduces airway remodeling, airway inflammation, and degree of oxidative stress by inhibiting Stat3 signaling through TSLP downregulation in a mouse asthma model.

  12. Results suggest combinatorial mechanisms involved in the tissue-selective regulation of thymic stromal lymphopoietin (TSLP) transcription in epidermal keratinocytes and intestinal epithelial cell(s) (IEC).

  13. these results suggest that TSLP-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection

  14. blockading the JAK/STAT pathway restrains inflammatory Th2 cell response induced by TSLP-DCs in allergic rhinitis.

  15. study concludes that IL-33 and TSLP are required for epithelial cell IL-25 expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection

  16. TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin in house dust mite (HDM)-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin and beta-catenin as well as phosphorylation(p)-AKT induced by HDM. In vitro, HDM increased the expression of TSLP and E-cadherin dysfunction by PI3K/Akt signaling pathway.

  17. this study shows that TSLP is a key target of Mi-2beta in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation

  18. These data demonstrate that multiple pathogenic strains of RSV induce IL-13-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection.

  19. the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.

  20. The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23/type 17 axes.

Guinea Pig Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. presence of epithelium-derived TSLP in the eustachian tubes plays important role in the onset of eosinophilic otitis media

Thymic Stromal Lymphopoietin (TSLP) Protein Überblick

Protein Überblick

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit TSLP

  • thymic stromal lymphopoietin (TSLP)
  • thymic stromal lymphopoietin (Tslp)
  • TSLP Protein

Bezeichner auf Proteinebene für TSLP

thymic stromal lymphopoietin , thymic stromal lymphopoetin , thymic stroma-derived lymphopoietin

GENE ID SPEZIES
706194 Macaca mulatta
737202 Pan troglodytes
100302635 Equus caballus
85480 Homo sapiens
53603 Mus musculus
688621 Rattus norvegicus
101788673 Cavia porcellus
607671 Canis lupus familiaris
617637 Bos taurus
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