Thymic Stromal Lymphopoietin Proteine (TSLP)

TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Zusätzlich bieten wir Ihnen Thymic Stromal Lymphopoietin Antikörper (195) und Thymic Stromal Lymphopoietin Kits (86) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TSLP 85480 Q969D9
TSLP 53603 Q9JIE6
TSLP 688621  
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Top Thymic Stromal Lymphopoietin Proteine auf antikoerper-online.de

Showing 10 out of 42 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Escherichia coli (E. coli) Maus Unkonjugiert 4 pack Anmelden zum Anzeigen 10 bis 12 Tage
$95.24
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Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 10 bis 12 Tage
$220.26
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Escherichia coli (E. coli) Human Unkonjugiert   0.01 mg Anmelden zum Anzeigen 2 bis 6 Tage
$324.50
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Escherichia coli (E. coli) Human Unkonjugiert   4 pack Anmelden zum Anzeigen 10 bis 12 Tage
$95.24
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Escherichia coli (E. coli) Human Unkonjugiert 10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$85.00
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Escherichia coli (E. coli) Human Unkonjugiert Validation with Western Blot 10 μg Anmelden zum Anzeigen 12 bis 15 Tage
$175.84
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
Details

TSLP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) , , , ,
, ,
Rat (Rattus)

Weitere Proteine zu Thymic Stromal Lymphopoietin (TSLP) Interaktionspartnern

Human Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. TSLP-induced phosphorylation of l-plastin (zeige LCP1 Proteine) is increased in atopic dermatitis and increases eosinophil migration.

  2. a hit expansion exercise yielded additional active compounds that could be amenable to further optimization, providing an opportunity to dissociate TSLP inhibition from other non-desired activities. This study illustrates the potential of phenotypic drug discovery to complement target based approaches by providing new chemistry and biology leads

  3. study found that among patients with atopic dermatitis (AD), common FLG (zeige FGFR1 Proteine) null mutations are associated with earlier AD onset in a dose-dependent manner, whereas TSLP rs1898671 appears unrelated to the timing of AD onset

  4. lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8 (zeige IL8 Proteine). Notably, both genera also lowered the TSLP expression in stimulated Caco-2 cells, regardless of the diet regimen.

  5. this review focuses on recent advances on the effects of TSLP on obstetrical and gynecological diseases, including pregnancy failure, endometriosis, and cervical cancer

  6. The increase in TSLP and TNF-alpha (zeige TNF Proteine) level observed in IS fluid was found to correlate with disease severity. The increased TSLP production from asthma sputum cells was abrogated by the addition of rIL (zeige PDLIM4 Proteine)-37. Regulation of TSLP pathway may be a therapeutic approach for asthma.

  7. House dust mite sublingual immunotherapy downregulated Th2-type immune responses mediated by the TSLP-OX40L (zeige TNFSF4 Proteine) signaling pathway in patients with persistent moderate to severe allergic rhinitis.

  8. The results suggest that IL-1beta (zeige IL1B Proteine) may be an early key mediator for the acquisition of an Atopic dermatitis (AD) phenotype through induction of thymic stromal lymphopoietin (TSLP) and alteration of the epidermal homeostasis.

  9. House dust mite exposure increases the expression of TSLP through PI3K/Akt signalin (zeige CDH1 Proteine)g pathway in human bronc (zeige HDAC3 Proteine)hial epithelial 16HBE cells.

  10. Posttranslational modifications control the functional activity of TSLP in humans and overproduction of TSLP may be a key trigger for the amplification of type 2 inflammation in diseases

Mouse (Murine) Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. blockading the JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) pathway restrains inflammatory Th2 cell response induced by TSLP-DCs in allergic rhinitis.

  2. study concludes that IL-33 (zeige IL33 Proteine) and TSLP are required for epithelial cell IL-25 (zeige IL25 Proteine) expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection

  3. TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin (zeige CDH1 Proteine) in house dust mite (HDM (zeige HDAC3 Proteine))-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin (zeige CDH1 Proteine) and beta-catenin (zeige CTNNB1 Proteine) as well as phosphorylation(p)-AKT (zeige AKT1 Proteine) induced by HDM (zeige HDAC3 Proteine). In vitro, HDM (zeige HDAC3 Proteine) increased the expression of TSLP and E-cadherin (zeige CDH1 Proteine) dysfunction by PI3K/Akt (zeige AKT1 Proteine) signaling pathway.

  4. this study shows that TSLP is a key target of Mi-2beta (zeige CHD4 Proteine) in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation

  5. These data demonstrate that multiple pathogenic strains of RSV induce IL-13 (zeige IL13 Proteine)-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection.

  6. the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.

  7. The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23 (zeige IL23A Proteine)/type 17 axes.

  8. this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33 (zeige IL33 Proteine), IL-25 (zeige IL25 Proteine) and TSLP

  9. TNF-alpha (zeige TNF Proteine) and IL-1beta (zeige IL1B Proteine), which are partly produced by LPS (zeige TLR4 Proteine)-activated leukocytes, contribute to TSLP production via TLR4 (zeige TLR4 Proteine) activation in vivo.

  10. IL-33 (zeige IL33 Proteine)-ERK (zeige EPHB2 Proteine)/JNK (zeige MAPK8 Proteine)/p38 (zeige CRK Proteine)/Egr-1 (zeige EGR1 Proteine)/TSLP axis involved in allergic skin Th2 inflammation

Thymic Stromal Lymphopoietin (TSLP) Protein Überblick

Protein Überblick

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit TSLP

  • thymic stromal lymphopoietin (TSLP)
  • thymic stromal lymphopoietin (Tslp)
  • TSLP Protein

Bezeichner auf Proteinebene für TSLP

thymic stromal lymphopoietin , thymic stromal lymphopoetin , thymic stroma-derived lymphopoietin

GENE ID SPEZIES
706194 Macaca mulatta
737202 Pan troglodytes
100302635 Equus caballus
85480 Homo sapiens
53603 Mus musculus
688621 Rattus norvegicus
101788673 Cavia porcellus
607671 Canis lupus familiaris
617637 Bos taurus
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