anti-Thrombomodulin (THBD) Antikörper

Human Thrombomodulin (THBD) Interaktionspartner

1. we for the first time demonstrated that TM binds to GPR15 (zeige GPR15 Antikörper) via its EGF (zeige EGF Antikörper)-like domain and exerts angiogenesis and cytoprotective function in vascular ECs.

2. Bioinformatics analysis and screening of controls strongly suggested that the THBD-p.Trp153Gly mutation might be related to RPL aetiology.

3. Taken together, our findings suggest that TM-PKCdelta (zeige PKCd Antikörper) interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications.

4. A heterozygous variant displaying autosomal dominant inheritance (c.1611 C>A) was found in the gene THBD which encodes the glycoprotein thrombomodulin. This sequence change results in a stop codon (p.Cys537Stop) and truncation of the protein

5. Lys (zeige LYZ Antikörper) 42, Lys (zeige LYZ Antikörper) 43, Lys (zeige LYZ Antikörper) 44 and Arg 12 are critical for the interaction of TAFI (zeige CPB2 Antikörper) with the thrombin (zeige F2 Antikörper)-thrombomodulin complex, which modulates its antifibrinolytic potential.

6. Ligation of anti-HLA class I and II antibodies produces different effects on the endothelial expression of TBM and on serum levels of TBM in transplant recipients.

7. Fibrinogen gamma acts as thrombomodulin II. (Review)

8. Thrombomodulin (TM) promotes angiogenesis by enhancing cell adhesion, migration, and FAK (zeige PTK2 Antikörper) activation through interaction with fibronectin (zeige FN1 Antikörper).

9. The elevation of serum thrombomodulin (sTM)level suggests that endothelial damage occurs in Abdominal Aortic Aneurysm pathogenesis.

10. This population-based cohort study within the ARIC study did not replicate the Hernandez et al. finding that carrying the minor allele of 3 THBD SNPs doubles the risk of venous thromboembolism in African Americans. In fact, the HRs of VTE among carriers of the minor allele were <1. HRs were similar for white subjects. A strand-flip did not explain the discrepancies.

Mouse (Murine) Thrombomodulin (THBD) Interaktionspartner

1. macrophage infiltration and neointima formation following arterial ligation-induced vascular injury were higher in wild-type than in myeloid-specific thrombomodulin-deficient mice

2. discovery of a novel physiological function of thrombomodulin-dependent activated protein C (zeige PROC Antikörper) generation within the CNS

3. The present study found that the fifth epidermal growth factor (zeige EGF Antikörper)-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C (zeige PROC Antikörper)-independent

4. the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis

5. Identified Nur77 (zeige NR4A1 Antikörper)/Nor1 (zeige NR4A3 Antikörper) as novel regulators of thrombomodulin expression and function in vascular endothelial cells.

6. TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF (zeige PDGFA Antikörper)-BB. In addition, rTMD23 has therapeutic potential in corneal injury

7. Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice

8. the recombinant epidermal growth factor (zeige EGF Antikörper)-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice

9. Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.

10. Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 (zeige HMGB1 Antikörper) and an independent mechanism.

Rabbit Thrombomodulin (THBD) Interaktionspartner

1. Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.