anti-Thrombomodulin (THBD) Antikörper

Human Thrombomodulin (THBD) Interaktionspartner

1. Thrombomodulin gene C1418T polymorphism is associated with Kawasaki disease.

2. SETD1A contributes to retinoic acid -induced thrombomodulin expression in vascular endothelial cells by modulating the activity and expression of KLF4.

3. we for the first time demonstrated that TM binds to GPR15 via its EGF-like domain and exerts angiogenesis and cytoprotective function in vascular ECs.

4. Bioinformatics analysis and screening of controls strongly suggested that the THBD-p.Trp153Gly mutation might be related to RPL aetiology.

5. Taken together, our findings suggest that TM-PKCdelta interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications.

6. A heterozygous variant displaying autosomal dominant inheritance (c.1611 C>A) was found in the gene THBD which encodes the glycoprotein thrombomodulin. This sequence change results in a stop codon (p.Cys537Stop) and truncation of the protein

7. Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-thrombomodulin complex, which modulates its antifibrinolytic potential.

8. Ligation of anti-HLA class I and II antibodies produces different effects on the endothelial expression of TBM and on serum levels of TBM in transplant recipients.

9. Fibrinogen gamma acts as thrombomodulin II. (Review)

10. Thrombomodulin (TM) promotes angiogenesis by enhancing cell adhesion, migration, and FAK activation through interaction with fibronectin.

11. The elevation of serum thrombomodulin (sTM)level suggests that endothelial damage occurs in Abdominal Aortic Aneurysm pathogenesis.

12. This population-based cohort study within the ARIC study did not replicate the Hernandez et al. finding that carrying the minor allele of 3 THBD SNPs doubles the risk of venous thromboembolism in African Americans. In fact, the HRs of VTE among carriers of the minor allele were <1. HRs were similar for white subjects. A strand-flip did not explain the discrepancies.

13. these results suggest a novel function for thrombomodulin as an adhesion molecule in monocytes, where it enhances cell adhesion by binding Ley, leading to beta2 integrin activation via p38 MAPK

14. TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling.

15. The present study found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C-independent

16. Case Report: CD141+ myeloid dentritic cell differentiation of a juvenile myelomonocytic leukemia.

17. the effect of thromobomodulin c.1418C > T polymorphism on the pathogenesis of venous thrombosis

18. The finding of a previously unrecognized fibrinolytic phenotype indicates that bleeding in Thrombomodulin-associated coagulopathy has a complex pathogenesis and highlights the pivotal role of TM as a regulator of hemostasis.

19. TM mediates cell proliferation and migration via the Epithelial-To-Mesenchymal Transition (EMT) biomarkercyclooxygenase (COX)-2

20. the whole THBD gene sequenced in patients with recurrent venous thromboembolism (VTE); found 8 polymorphisms in the THBD gene in Swedish population; none of these polymorphisms was significantly associated with the risk of VTE recurrence; results indicate that THBD polymorphisms may not be a risk factor for VTE recurrence

Mouse (Murine) Thrombomodulin (THBD) Interaktionspartner

1. macrophage infiltration and neointima formation following arterial ligation-induced vascular injury were higher in wild-type than in myeloid-specific thrombomodulin-deficient mice

2. discovery of a novel physiological function of thrombomodulin-dependent activated protein C generation within the CNS

3. The present study found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C-independent

4. the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis

5. Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells.

6. TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF-BB. In addition, rTMD23 has therapeutic potential in corneal injury

7. Membrane-bound TM in macrophages plays an essential role in the development of abdominal aortic aneurysms by enhancing proinflammatory mediator elaboration, macrophage recruitment, and oxidative stress.

8. Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice

9. the recombinant epidermal growth factor-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice

10. Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.

11. Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism.

12. The lectin-like domain of TM does not play an important role in the host response to M. tuberculosis infection in mice.

13. Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.

14. TM has a critical role in skin differentiation and wound healing.

15. TM's lectin-like domain constrains glucose-induced complement activation on endothelial cells and podocytes and ameliorates albuminuria and glomerular damage.

16. FFAs inhibit TM-EPCR-Protein C system in endothelial cells through activating JNK signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome.

17. Genetic or acquired thrombomodulin defects might have an impact on the severity of microangiopathic lesions after exposure to Shiga toxin-producing E. coli infections.

18. we conclude that monocytic membrane-bound thrombomodulin participates in the LPS- and gram-negative bacteria-induced inflammatory response.

19. Recombinant thrombomodulin domains 2 and 3 protein significantly reduces atherosclerosis and neointima formation through its thrombin-binding ability.

20. RHBDL2 and soluble thrombomodulin were upregulated in ex vivo tissue culture of injured mouse skin. 3,4-Dichloroisocoumarin inhibited thrombomodulin production and wound healing; this was reversed by recombinant thrombomodulin in mice.

Rabbit Thrombomodulin (THBD) Interaktionspartner

1. Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.