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PROCR, but not THBD, polymorphisms are associated with early-onset ischemic stroke in young Caucasians. There were no PROCR or THBD associations in African-Americans.
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the oscillatory upregulation of TM expression on the endothelial cells over the course of retinoic acid therapy could potentially contribute to the treatment of coagulation abnormalities in cancer patients.
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Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin.
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Thrombomodulin gene C1418T polymorphism is associated with Kawasaki disease.
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SETD1A contributes to retinoic acid -induced thrombomodulin expression in vascular endothelial cells by modulating the activity and expression of KLF4.
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we for the first time demonstrated that TM binds to GPR15 via its EGF-like domain and exerts angiogenesis and cytoprotective function in vascular ECs.
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Bioinformatics analysis and screening of controls strongly suggested that the THBD-p.Trp153Gly mutation might be related to RPL aetiology.
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Taken together, our findings suggest that TM-PKCdelta interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications.
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A heterozygous variant displaying autosomal dominant inheritance (c.1611 C>A) was found in the gene THBD which encodes the glycoprotein thrombomodulin. This sequence change results in a stop codon (p.Cys537Stop) and truncation of the protein
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Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-thrombomodulin complex, which modulates its antifibrinolytic potential.
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Ligation of anti-HLA class I and II antibodies produces different effects on the endothelial expression of TBM and on serum levels of TBM in transplant recipients.
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Fibrinogen gamma acts as thrombomodulin II. (Review)
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Thrombomodulin (TM) promotes angiogenesis by enhancing cell adhesion, migration, and FAK activation through interaction with fibronectin.
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The elevation of serum thrombomodulin (sTM)level suggests that endothelial damage occurs in Abdominal Aortic Aneurysm pathogenesis.
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This population-based cohort study within the ARIC study did not replicate the Hernandez et al. finding that carrying the minor allele of 3 THBD SNPs doubles the risk of venous thromboembolism in African Americans. In fact, the HRs of VTE among carriers of the minor allele were <1. HRs were similar for white subjects. A strand-flip did not explain the discrepancies.
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these results suggest a novel function for thrombomodulin as an adhesion molecule in monocytes, where it enhances cell adhesion by binding Ley, leading to beta2 integrin activation via p38 MAPK
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TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling.
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The present study found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C-independent
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Case Report: CD141+ myeloid dentritic cell differentiation of a juvenile myelomonocytic leukemia.
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the effect of thromobomodulin c.1418C > T polymorphism on the pathogenesis of venous thrombosis
