Thrombomodulin Antikörper

Produktnummer ABIN669636

Der Kaninchen Polyklonal anti-Thrombomodulin Antikörper (ABIN669636) detektiert spezifisch Thrombomodulin in WB, IF, IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für Thrombomodulin Antikörper (ABIN669636)

Target: Thrombomodulin (THBD)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Thrombomodulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Thrombomodulin Antikörper

Verwendungszweck: Thrombomodulin Polyclonal Antibody

Kreuzreaktivität: Rind (Kuh), Hund, Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Thrombomodulin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:500-2000), IHC-P(1:100-500), IHC-F(1:100-500), IF(1:100-500)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Thrombomodulin

Target: Thrombomodulin (THBD)

Andere Bezeichnung: Thrombomodulin

Hintergrund:

Synonyms: Thrombomodulin, CD 141, CD141, CD141 antigen, Fetomodulin, THBD, THRM, TM, AHUS 6, AHUS6, BDCA 3, BDCA3, THPH12, TRBM_HUMAN.

Background: Thrombomodulin, TM is cell surface glycoprotein, plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules.CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII, thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Molekulargewicht: 61kDa

Gen-ID: 21824