anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) Antikörper

TIMP1 belongs to the TIMP gene family. Zusätzlich bieten wir Ihnen TIMP1 Proteine (61) und TIMP1 Kits (50) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TIMP1 7076 P01033
TIMP1 116510 P30120
TIMP1 21857 P12032
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Top anti-TIMP1 Antikörper auf

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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-TIMP1 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti-TIMP1 antibody, Western blotting Lane 1: Recombinant Human TIMP-1 Protein 10ng Lane 2: Recombinant Human TIMP-1 Protein 5ng Lane 3: Recombinant Human TIMP-1 Protein 2.5ng 100 μg 4 bis 6 Tage
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of TIMP1 using anti-TIMP1 antibody . Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane 1: human Hela whole cell lysates, Lane 2: rat ovary tissue lysates, Lane 3: rat lung tissue lysates, Lane 4: mouse ovary tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TIMP1 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 ug/mL overnight at 4℃, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for TIMP1 at approximately 23KD. The expected band size for TIMP1 is at 23KD. 100 μg 4 bis 6 Tage
Human Kaninchen Unkonjugiert IF (cc), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti-TIMP-1(NT) Polyclonal Antibody, Unconjugated (ABIN668331) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded rabbit liver tissue labeled with Rabbit Anti-TIMP-1(NT) Polyclonal Antibody, Unconjugated (ABIN668331) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL 3 bis 7 Tage
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL 2 bis 3 Tage
Human Kaninchen Unkonjugiert WB Western blot (WB) analysis of TIMP-1 (G94) pAb at 1:500 dilution Lane1:CT26 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug) 100 μL 3 bis 4 Tage
Human Ziege Unkonjugiert ELISA, WB   100 μg 6 bis 7 Tage
Rind (Kuh) Kaninchen Unkonjugiert ELISA, ICC, IF, IHC (p), WB Immunohistochemical staining of paraffin embedded mouse skin tissue using TIMP1 antibody (primary antibody at 1:100) Immunohistochemical staining of mouse skin tissue using TIMP1 antibody (dilution of primary antibody - 1:400) 100 μg 10 bis 15 Tage
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from rat brain cells, using TIMP1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 bis 3 Tage
Human Kaninchen Unkonjugiert EIA, WB Formalin-fixed and paraffin-embedded human breast carcionma reacted with TIMP1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of TIMP1 Antibody (N-term) in CEM cell line lysates (35ug/lane). TIMP1 (arrow) was detected using the purified Pab. 0.4 mL 6 bis 8 Tage
Maus Kaninchen Unkonjugiert ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Mouse Kidney Cancer Tissue. 100 μg 15 bis 18 Tage

Am meisten referenzierte anti-TIMP1 Antikörper

  1. Human Polyclonal TIMP1 Primary Antibody für IHC (p), WB - ABIN3044394 : Jiang, Han, Li, Yang, Liu: Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo. in Carbohydrate polymers 2015 (PubMed)
    Show all 22 Pubmed References

  2. Human Polyclonal TIMP1 Primary Antibody für ELISA, WB - ABIN5519064 : Li, Liu, Zhang, Zhu, He, Xiao: Effects of augmentation of liver regeneration recombinant plasmid on rat hepatic fibrosis. in World journal of gastroenterology 2005 (PubMed)
    Show all 14 Pubmed References

  3. Human Monoclonal TIMP1 Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899800 : Li, Hou, Shao, Tang, Li: The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy. in Biology of reproduction 2010 (PubMed)
    Show all 13 Pubmed References

  4. Human Polyclonal TIMP1 Primary Antibody für IF (cc), IF (p) - ABIN668331 : Sassoli, Nosi, Tani, Chellini, Mazzanti, Quercioli, Zecchi-Orlandini, Formigli: Defining the role of mesenchymal stromal cells on the regulation of matrix metalloproteinases in skeletal muscle cells. in Experimental cell research 2014 (PubMed)
    Show all 9 Pubmed References

  5. Human Polyclonal TIMP1 Primary Antibody für WB - ABIN6712203 : Lu, Lu, Li, Li, Zhao, Lin, Guo: Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway. in Toxicology letters 2012 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal TIMP1 Primary Antibody für IHC (p), ELISA - ABIN533559 : Hoikkala, Pääkkö, Soini, Mäkitaro, Kinnula, Turpeenniemi-Hujanen: Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2--complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma. in Cancer letters 2006 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal TIMP1 Primary Antibody für ICC, IF - ABIN261639 : Jurga, Piotrowska, Makuch, Przewlocka, Mika: Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model. in Frontiers in pharmacology 2017 (PubMed)

  8. Human Monoclonal TIMP1 Primary Antibody für ELISA, WB - ABIN2476827 : Koike, Vernon, Hamner, Sadoun, Reed: MT1-MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3-dimensional collagen gels. in Journal of cellular biochemistry 2002 (PubMed)

  9. Cow (Bovine) Polyclonal TIMP1 Primary Antibody für IHC (p), ELISA - ABIN2476830 : Goldraich, Ramos, Goldraich: Urography versus DMSA scan in children with vesicoureteric reflux. in Pediatric nephrology (Berlin, Germany) 1990 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen TIMP1 Interaktionspartner

Human TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. There is no association of 372 T > C (Phe124Phe) polymorphism in the TIMP-1 with heart failure susceptibility and prognosis in Brazilian population.

  2. A low expression of TIMP1 and TIMP2 is correlated with advanced stages of meningioma.

  3. Imbalance in the metalloproteinase (MMP2, MMP9) to inhibitor tissue expression (TIMP1, TIMP2) in the vessel wall (the cross-sections of the internal thoracic artery, radial artery, and saphenous vein) might predispose to aortocoronary graft failure after coronary artery bypass grafting. A stronger expression of TIMPs than MMPs in the arterial grafts might explain favourable long-term outcomes.

  4. Elevated MMP-1 and reduced TIMP-1 were found in obstructed defecation syndrome associated with internal rectal prolapse

  5. High serum Level of TIMP1 is associated with large bowel adenoma.

  6. TIMP-1 plays a negative regulatory role in the proliferation and osteogenesis of hBMSCs, at least partially, through Wnt/beta-catenin signaling.

  7. imbalance between MMP-9 and TIMP-1 could play an important role in metastatic spread via lymphatic pathways of head and neck squamous cell carcinoma cells

  8. Low density lipoprotein (-) induced the release of MMP-9 and TIMP-1 in monocytes through CD14.

  9. The versatile impact of TIMP-1 on cellular functions stems from its two-domain structure harboring metalloproteinase-inhibitory and cytokine-like signaling activities.

  10. Data demonstrate significantly higher serum concentrations of inflammatory biomarkers MMP-8, MPO and TIMP-1 in acute ischemic stroke cases.

  11. our findings demonstrate overexpression of TIMP1 in mouse and human gastric cancers through NF-kB-dependent mechanism. We also show that TFF1 suppresses NF-kappaB and inhibits TIMP1-mediated proliferative potential in gastric cancer.

  12. TIMP-1 expression exhibits an upper moderate diagnostic value in CRC

  13. Serum levels of TIMP-1 were identified as a clinically useful marker for distinguishing NAFLD patients with and without significant fibrosis.

  14. Comparatively lower expression of MMP-7 in gastric mucosal inflammation and imbalanced expression of TIMP-1 might be two of the pathogeneses of chronic stomach disease

  15. Findings indicated that IL-32gamma suppressed skin carcinogenesis through the inhibition of both stemness and the inflammatory tumor microenvironment by the downregulation of TIMP-1 and ITGAV via inactivation of NF-kappaB signaling.

  16. we have shown that deleterious variation in TIMP3 is associated with bicuspid aortic valve and indices of thoracic aortic aneurysm. We further found that there is a synergistic interaction between loss of the X chromosome gene, TIMP1, and deleterious variation in TIMP3 that significantly increases that risk.

  17. MMP-8 and TIMP-1 in serum, but not MMP-9, identified colorectal cancer patients with bad prognosis

  18. Moreover, the shift in the TIMP-1/ MMP-1 ratio identifies increased synthesis of TIMP-1 as one of the processes associated with collagen I overproduction in HGF fibroblasts.

  19. TGF-beta1 appears to promote CAD through the induction of cell apoptosis by upregulating SPHK1 expression and further upregulating its downstream TIMP-1.

  20. significantly increased in the serum of type 2 diabetes mellitus patients with diabetic retinopathy

Cow (Bovine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.

  2. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.

  3. Production of TIMP-1 was augmented by IL-1alpha, TNFalpha, and hepatocyte growth factor at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.

  4. the different temporal expression patterns of TIMP-1 and TIMP-2 suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance

  5. Identification, purification and partial characterization of bovine pulmonary artery smooth muscle tissue inhibitor of matrix metalloproteinase-1

  6. analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor

Pig (Porcine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. Results provide evidence for the utility of MMP9 and TIMP1 as markers of age- and lactocrine-sensitive porcine female reproductive tract development.

  2. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity.

  3. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A, pro-MMP-9, MMP-2, VEGFR-1, VEGFR-2, and TIMP-1, which may contribute to the development of venous stenosis.

  4. Results indicate that leukemia inhibitory factor (LIF) and Oncostatin M increase the expression of MMP-1, MMP-3, and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF antagonist MH35-BD.

Rabbit TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. There were clear time-dependent degenerative changes in the histology of the medial meniscus after PCL rupture. The high expression of TIMP-1, MMP-1 and MMP-13 in the cartilage may be responsible for the degeneration, and PCL rupture may trigger meniscus degradation and ultimately osteoarthritis

  2. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 and TIMP-1 in rabbits with acute paraquat poisoning.

Mouse (Murine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. The data suggest that Timp1 promotes the immune response in the lungs after influenza infection facilitating an injurious phenotype as a result of influenza infection.

  2. the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host's immunological status.

  3. conclude that the intrinsic dynamics of TIMP-1 are not involved in its binding to LRP-1 but rather in the initiation of endocytosis and associated biological effects.

  4. Study implicated TIMP1, released from the vasculature, as a mediator of the tumorpromoting effects of endothelial PECAM1, thus suggesting its potential role in the progression of metastatic tumors.

  5. miR-138 and ER stress were induced in osteoporosis and then promoted the apoptosis of osteoblasts, at least in part, through TIMP-1.

  6. TIMP-1 is upregulated in liver fibrosis and hepatocellular carcinoma, potentially implying diagnostic relevance in the non-invasive assessment of liver fibrosis or in HCC detection6. However, our study in TIMP-1-deficient mice did not confirm a functional role of TIMP-1 in the development of liver fibrosis or hepatocellular carcinoma.

  7. In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 and TGF-beta1 at transcriptional and translational levels

  8. gingival fibroblasts cell-based therapy is a promising approach to inhibit aneurysm progression and rupture through local production of Timp-1

  9. These results show that MMP-9/TIMP-1 system disturbance and changes of histological structure in uteri tissue are involved in fluoride-induced reproductive dysfunctions.

  10. Tissue inhibitor of matrix metalloproteinases 1 (TIMP1) inhibition resensitized tumors to gemcitabine and radiotherapy.

  11. proteomic analysis of the mesenchymal stem cells secretome identified the TIMP-1 as a potential effector molecule responsible for the anti-angiogenic properties of MSC

  12. TIMP1 signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.

  13. This study highlights a previously undescribed integral role for TIMP1 in both vascular network maturation and adaptations to ischemia or alterations in flow.

  14. TIMP-1 was identified as a selectively upregulated component secreted from immature astrocytes from human pluripotent stem cells.

  15. demonstrate that TIMP-2 plays a greater protective role than TIMP-1 during the pathogenesis of atherosclerosis

  16. Our findings reveal that elevated levels of TIMP-1 impact on neutrophil homeostasis via signaling through CD63.

  17. TIMP-1 is a ligand of LRP-1 and we highlight a new example of its MMP-independent, cytokine-like functions.

  18. RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis.

  19. PDGF-D intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2/MMP-9 system, and PDGF-D signaling is mediated through both PDGF-alpha and -beta receptors.

  20. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK signaling pathway.

TIMP1 Antigen-Profil

Protein Überblick

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Genbezeichner und Symbole assoziert mit TIMP1

  • TIMP metallopeptidase inhibitor 1 (TIMP1) Antikörper
  • TIMP metallopeptidase inhibitor 1 (Timp1) Antikörper
  • tissue inhibitor of metalloproteinase 1 (Timp1) Antikörper
  • Clgi Antikörper
  • DKFZp468A0912 Antikörper
  • EPA Antikörper
  • EPO Antikörper
  • HCI Antikörper
  • Timp Antikörper
  • TIMP-1 Antikörper
  • TIMP1 Antikörper

Bezeichner auf Proteinebene für TIMP1

tissue inhibitor of matrix metalloproteinase-1 , TIMP metallopeptidase inhibitor 1 , Metalloproteinase inhibitor 1 , TIMP-1 , collagenase inhibitor , erythroid potentiating activity , erythroid-potentiating activity , fibroblast collagenase inhibitor , metalloproteinase inhibitor 1 , tissue inhibitor of metalloproteinases 1 , EG-1 , embryogenin-1 , tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) , tissue inhibitor of metallopeptidase 1 , tissue inhibitor of metalloproteinase 1 , metalloproteinase tissue inhibitor , metalloproteinase tissue inhibitor 1 , EPA , TPA-S1 , TPA-induced protein , collagenase inhibitor 16C8 fibroblast , tissue inhibitor of metalloproteinase-1

574348 Macaca mulatta
100172253 Pongo abelii
7076 Homo sapiens
282092 Bos taurus
116510 Rattus norvegicus
101686851 Mustela putorius furo
443331 Ovis aries
396862 Sus scrofa
403816 Canis lupus familiaris
100009047 Oryctolagus cuniculus
21857 Mus musculus
100034220 Equus caballus
Ausgewählte Anbieter für anti-TIMP1 (TIMP1) Antikörper
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