TIMELESS Interacting Protein (TIPIN) ELISA Kits

Required for normal progression of S-phase. Zusätzlich bieten wir Ihnen TIPIN Antikörper (71) und TIPIN Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
TIPIN 54962 Q9BVW5
TIPIN 66131 Q91WA1
TIPIN 363076 Q4QR88
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Top TIPIN ELISA Kits auf antikoerper-online.de

Showing 5 out of 5 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Ratte
  96 Tests 15 bis 18 Tage
$875.60
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Maus
  96 Tests 15 bis 18 Tage
$875.60
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Human
  96 Tests 15 bis 18 Tage
$875.60
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Rind (Kuh)
  96 Tests 15 bis 18 Tage
$1,029.60
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Huhn
  96 Tests 15 bis 18 Tage
$1,095.60
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Weitere ELISA Kits für TIPIN Interaktionspartner

Human TIMELESS Interacting Protein (TIPIN) Interaktionspartner

  1. the 1.85 A crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, is presented and this region of human Timeless harbours a partial binding site for Tipin.

  2. TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer.

  3. Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer DNA ligand.

  4. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins.

  5. We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.

  6. RPA-covered ssDNA not only supports recruitment and activation of ATR but also, through Tipin and Claspin, it plays an important role in the action of ATR on its critical downstream target Chk1

  7. The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.

  8. Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin in response to replication checkpoint

  9. observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells

  10. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

  11. These findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement, Tipin interacts with RPA on DNA.

Mouse (Murine) TIMELESS Interacting Protein (TIPIN) Interaktionspartner

  1. mTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes

  2. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

  3. The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.

Xenopus laevis TIMELESS Interacting Protein (TIPIN) Interaktionspartner

  1. Mta2 and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.

  2. data indicate that Tipin/Tim1/And1 form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion

TIPIN Antigen-Profil

Beschreibung des Gens

Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be required in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).

Genbezeichner und Symbole assoziert mit TIPIN

  • TIMELESS interacting protein (TIPIN) Antikörper
  • timeless interacting protein (Tipin) Antikörper
  • timeless interacting protein S homeolog (tipin.S) Antikörper
  • timeless interacting protein (tipin) Antikörper
  • timeless interacting protein L homeolog (tipin.L) Antikörper
  • TIMELESS interacting protein (Tipin) Antikörper
  • 1110005A05Rik Antikörper
  • 1110018P21Rik Antikörper
  • MGC82649 Antikörper
  • RGD1564084 Antikörper
  • tipin Antikörper
  • zgc:91928 Antikörper

Bezeichner auf Proteinebene für TIPIN

CSM3 homolog , TIMELESS-interacting protein , timeless interacting protein , TIMELESS interacting protein , timeless-interacting protein , mitotic phosphoprotein 67

GENE ID SPEZIES
54962 Homo sapiens
66131 Mus musculus
363076 Rattus norvegicus
415548 Gallus gallus
444047 Xenopus laevis
445058 Danio rerio
453525 Pan troglodytes
506176 Bos taurus
100126681 Xenopus (Silurana) tropicalis
100683743 Canis lupus familiaris
394376 Xenopus laevis
100719663 Cavia porcellus
100348340 Oryctolagus cuniculus
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