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TAPBP encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. Zusätzlich bieten wir Ihnen und TAPBP Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal TAPBP Primary Antibody für IHC, IHC (p) - ABIN4357823
Sokol, Koelzer, Rau, Karamitopoulou, Zlobec, Lugli: Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer. in Journal of translational medicine 2015
Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. Tpn defined the characteristic carboxy termini of canonical MHC I peptides.
modification of Tapasin can enhance the presentation of targeting antigens via intracellular delivery to DCs and elicit specific CTL immune responses efficiently
Data show that tapasin expression is enhanced by beta 2-microglobulin (zeige B2M Antikörper) via both transcriptional and post-transcriptional mechanisms.
Deletion of a loop within the tapasin C-terminal Ig-like domain (Delta334-342) prevented tapasin association with the MHC class I molecule K(d).
E2F1 (zeige E2F1 Antikörper) is an essential transcription factor for tapasin.
showed that a large disulfide-bonded complex was present in the mouse cells that included ERp57 (zeige PDIA3 Antikörper), tapasin, and K(d).
Role of tapasin in MHC class I antigen presentation in vivo.
Data show that cell surface expression of TAP-independent class I complexes is modulated by tapasin levels and is enhanced by interferon-gamma (zeige IFNG Antikörper).
tapasin has a essential function of tapasin in quality control of HLA-G (zeige HLAG Antikörper) molecules
A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression.
The results demonstrated that the mRNA expression levels of tapasin were significantly downregulated in patients with chronic hepatitis B (CHB) compared with in healthy controls and patients with acute hepatitis B Furthermore, the apoptotic rate of CD8 (zeige CD8A Antikörper)+ T cells was increased in patients with CHB compared with in the other two groups.
The disruption of TAP1 (zeige TAP1 Antikörper) and TAPBP generates pluripotent embryonic stem cells with reduced immunogenicity.
Fluctuation and entropy analyses show how tapasin chaperones major histocompatibility complex class I by stabilising it in a peptide-receptive conformation.
reduction in tapasin expression is associated with tumor progression in colorectal cancer
Data suggest that tapasin (Tsn) binds to MHC I with suboptimal cargo and thereby adjusts the energy landscape in favor of MHC I complexes with immunodominant epitopes.
TAP/TPN complex formation is driven by hydrophobic interactions via leucine zipper-like motifs.
TAP2 (zeige TAP2 Antikörper), HLA-DOA (zeige HLA-DOA Antikörper), HLA-DOB (zeige HLA-DOB Antikörper), and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population
Analysis of expression of tapasin and/or HLA-I may be of value as prognostic tool for glioblastoma multiforme patients, especially when considering immunotherapy.
Modified TAPBP gene function may contribute to the development of refractory chronic rhinosinusitis via reduction of circulating CD8 (zeige CD8A Antikörper) lymphocytes.
Targeted re-sequencing identified rs3106189 at the 5' UTR (zeige UTS2R Antikörper) of TAPBP and rs1052918 at the 3' UTR (zeige UTS2R Antikörper) of TCF3 (zeige TCF3 Antikörper) to be associated with the overall survival of colorectal cancer patients.
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
, TAP binding protein
, TAP-associated protein
, TAP-binding protein