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SYCP3 encodes an essential structural component of the synaptonemal complex.
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Cat (Feline) Polyclonal SYCP3 Primary Antibody für ICC, IHC (fro) - ABIN152572
Liu, Wu, Lyu, Yang, Albertini, Keefe, Liu: Germline stem cells and neo-oogenesis in the adult human ovary. in Developmental biology 2007
Show all 34 Pubmed References
Human Polyclonal SYCP3 Primary Antibody für ICC, IHC (fro) - ABIN152571
Dann, Alvarado, Molyneux, Denard, Garbers, Porteus: Spermatogonial stem cell self-renewal requires OCT4, a factor downregulated during retinoic acid-induced differentiation. in Stem cells (Dayton, Ohio) 2008
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Cow (Bovine) Polyclonal SYCP3 Primary Antibody für ICC, IF - ABIN152570
Takada, Isono, Shinga, Turner, Kitamura, Ohara, Watanabe, Singh, Kamijo, Jenuwein, Burgoyne, Koseki: Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. in Development (Cambridge, England) 2007
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Polyclonal SYCP3 Primary Antibody für IF, IHC (p) - ABIN540276
Onorato, Brown, Morris: Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2. in Journal of andrology 2008
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Human Monoclonal SYCP3 Primary Antibody für ICC, FACS - ABIN1724892
Alsheimer, Baier, Schramm, Schütz, Benavente: Synaptonemal complex protein SYCP3 exists in two isoforms showing different conservation in mammalian evolution. in Cytogenetic and genome research 2010
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Human Monoclonal SYCP3 Primary Antibody für ICC, FACS - ABIN1724891
Chung, Kitano, Takikita, Cho, Noh, Kim, Ylaya, Hanaoka, Fukuoka, Hewitt: Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer. in Human pathology 2013
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Human Monoclonal SYCP3 Primary Antibody für ELISA, FACS - ABIN4352291
Zhuang, Tang, Feng, Liu, Zhu, Yan, Liu, Liu, Qiao: Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis. in Cell cycle (Georgetown, Tex.) 2016
Immunohistochemical observations revealed that Sycp3 is specifically localized in spermatocytes in typical nuclear patterns at each meiotic stage.
SYCP1 (zeige SYCP1 Antikörper) and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes.
Unlike other vertebrates, rat and mouse SYCP3 exists in 2 isoforms; the short isoform is conserved in vertebrates and the longer isoform, appeared 15 million years ago in a common ancestor of rat and mouse and after separation from the hamster branch.
X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity
absence of synaptonemal complex protein 3 (SCP3) promotes aneuploidy in murine oocytes by inducing defective meiotic chromosome segregation
In Scp3-deficient (knockout) mice, spermatogenesis and testicular degeneration are augmented when E2F1 (zeige E2F1 Antikörper) is also deficient.
Rad21 (zeige RAD21 Antikörper), and the superimposed SCP3 and SCP2 (zeige CRISP3 Antikörper), are involved in the monopolar attachment of sister kinetochores during meiosis I
SYCP2 (zeige SYCP2 Antikörper) and SYCP3 proteins function in the specificity of chromatin attachment to the chromosome core
SYCP3 has a temporally restricted role in maintaining, but not establishing, cohesin-core organization during prophase I.
The SYCP3 is expressed in germ cell-like cells. The nuclear distribution of SYCP3 in the germ cell-like cells is highly abnormal and not associated with the chromosomes of these cells.
DNA double-stranded breaks are inefficiently repaired in Sycp3(-)(/)(-) oocytes, thereby generating a temporal spectrum of recombination errors. T
SCP3 (zeige CTDSPL Antikörper) is associated with lymphangiogenesis and provides insight into the SCP3 (zeige CTDSPL Antikörper)-VEGF-C (zeige VEGFC Antikörper)/VEGF-D (zeige Figf Antikörper) axis based cancer therapy strategy.
In the model, the reported compaction of chromosomal DNA caused by SYCP3 would result from its ability to bridge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-like structure.
SYCP3 binds to RAD51 (zeige RAD51 Antikörper) and attenuates RAD51 (zeige RAD51 Antikörper) activity during meiosis.
SYCP3 binding and assembly on meiotic chromosomes leads to their organisation into compact structures compatible with recombination and crossover formation
The T657C polymorphism of the SYCP3 gene is possibly associated with recurrent pregnancy loss of unknown cause in human.
SCP3 (zeige CTDSPL Antikörper) plays an important role in the progression of cervical cancer
SYCP3 mutations are not associated with the genetic susceptibility for meiotic arrest in infertile male patients with nonobstructive azoospermia in the Turkish population
screening for genetic variants in AURKB (zeige AURKB Antikörper) and SYCP3 among these patients with reproductive problems using Sanger sequencing. Only one apparently non-pathogenic deletion was found in SYCP3.
Positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival.
mutations in SYCP3 do not contribute significantly to risk for recurrent miscarriage through maternal meiotic nondisjunction.
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.
, diacylglycerol cholinephosphotransferase 1
, synaptonemal complex protein 3
, synaptonemal complex protein 3-like
, Meiotic chromosome core protein
, Synaptonemal complex protein COR1