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Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Zusätzlich bieten wir Ihnen SUV39H2 Antikörper (121) und und viele weitere Produktgruppen zu diesem Protein an.
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Our finding unveils a novel autoregulatory mechanism of SUV39H2 through lysine automethylation
Our data show that the differential expression of SUV39H1 (zeige SUV39H1 Proteine) and SUV39H2 is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution
SUV39H2 functioned cooperatively with MAGE-A11 to increase androgen-dependent AR transcriptional activity.
histone H3 (zeige HIST3H3 Proteine) lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase (zeige MBD2 Proteine) KDM4C (zeige KDM4C Proteine), was found in CD4 (zeige CD4 Proteine)(+) T lymphocytes of Latent autoimmune diabetes in adults patients
data cannot finally exclude H2AX (zeige H2AFX Proteine) methylation of SUV39H2 in cells, additional experimental evidence is required to validate this claim.
Our results reveal the regulatory mechanism of LSD1 (zeige KDM1A Proteine) protein through its lysine methylation by SUV39H2 in human cancer cells
We also demonstrate that the N324K mutant in the SET domain of SUV39H2 that has been shown to cause an inherited nasal skin disease in Labrador Retrievers renders SUV39H2 inactive
Expression of JHDM2A (zeige KDM3A Proteine) was significantly increased but HDAC2 (zeige HDAC2 Proteine), HDAC7 (zeige HDAC7 Proteine), and SUV39H2 were significantly down-regulated in Systemic Sclerosis B cells relative to controls
genetic association studies in a Finnish population with type I diabetes: The minor T allele of exonic SNP rs17353856 in SUV39H2 is associated with diabetic retinopathy (in a larger meta-analysis); thus an genetic variation may be protective.
findings suggest that Suv39H1 (zeige SUV39H1 Proteine) and Suv39H2 are key hypoxia-induced methyltransferases; their decline in fetal lung during late gestation is critical for epigenetic changes resulting in the developmental induction of SP-A
The authors show here that the mouse Suv39h2 enzyme differs from Suv39h1 (zeige SUV39H1 Proteine) by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an additional affinity for major satellite repeat RNA.
Data indicate that histone methyltransferase Suv39h2 expression is up-regulated in the liver in liver steatosis.
Repeat-associated, Suv39h (zeige SUV39H1 Proteine)-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
ESET (zeige SETDB1 Proteine) histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1 (zeige HDAC1 Proteine)/2 that participates in multiple pathways of transcriptional repression.
Taken together, the results indicate epigenetic regulation of telomere length in mammals by Suv39h1 (zeige SUV39H1 Proteine) and Suv39h2.
Knockdown of SUV39H1 (zeige SUV39H1 Proteine) and SUV39H2 in embryonic stem-like cells and embryonic fibroblasts increases telomere length.
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).
, histone H3-K9 methyltransferase 2
, histone-lysine N-methyltransferase SUV39H2
, lysine N-methyltransferase 1B
, su(var)3-9 homolog 2
, Suv39h histone methyltransferase
, suppressor of variegation 3-9 homolog 2 (Drosophila)
, histone-lysine N-methyltransferase SUV39H2-like