Sulfatase Modifying Factor 1 Proteine (SUMF1)

SUMF1 encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Zusätzlich bieten wir Ihnen SUMF1 Antikörper (61) und SUMF1 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SUMF1 285362 Q8NBK3
SUMF1 58911 Q8R0F3
Ratte SUMF1 SUMF1 362409  
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Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$576.00
Details
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$860.20
Details
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,924.17
Details
Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$554.33
Details

SUMF1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Sulfatase Modifying Factor 1 (SUMF1) Interaktionspartnern

Human Sulfatase Modifying Factor 1 (SUMF1) Interaktionspartner

  1. We show that SUMF1 expression is affected in COPD (zeige ARCN1 Proteine) patients compared to controls, and that SNPs in SUMF1 are associated with an increased risk of COPD (zeige ARCN1 Proteine). Certain COPD (zeige ARCN1 Proteine)-associated SNPs have effects on either SUMF1 gene expression or on lung function. Collectively, this study shows that SUMF1 is associated with an increased risk of developing COPD (zeige ARCN1 Proteine).

  2. SUMF1 catalyses a monooxygenase type of reaction.

  3. This detailed clinical description and follow-up of a cohort of patients, together with the molecular characterisation of their underlying defects, contribute to improved knowledge of multiple sulfatase deficiency.

  4. MSD (zeige MESDC2 Proteine) presenting in the newborn period with hypotonia, apnoea, cyanosis and rolling eyes, hepato-splenomegaly and deafness. This patient was compound heterozygous for two so far undescribed SUMF1 mutations (c.191C > A; p.S64X and c.818A > G; p.D273G

  5. The complete kinetic parameters for both forms of FGE are described, along with a proposed mechanism for FGE catalysis that accounts for the copper-dependent activity.

  6. A novel missense mutation & an insertional truncating mutation in SUMF1 gene causing nultiple sulphatase deficiency.

  7. furin (zeige FURIN Proteine)-mediated processing of FGE during secretion is a physiological means of higher eukaryotic cells to regulate FGE activity upon exit from the endoplasmic reticulum

  8. Phenotypic outcome in Multiple Sulfatase Deficiency depends on both residual FGE activity as well as protein stability.

  9. This study identified genetic variation of SUMF1 in genes associated with in vivo glutamate (zeige GRIN1 Proteine) measured using 1H magnetic resonance spectroscopic imaging in the grey matter of patients with multiple sclerosis.

  10. mutational analysis of SUMF1 in 20 Multiple sulfatase deficiency patients of different ethnic origin

Mouse (Murine) Sulfatase Modifying Factor 1 (SUMF1) Interaktionspartner

  1. Sumf1(-/-) astrocytes failed to support the survival and function of wild-type cortical neurons, suggesting a non-cell autonomous mechanism for neurodegeneration.

  2. Sumf1 controls hematopoietic stem progenitor cell differentiation and hematopoietic lineage development through FGF and Wnt (zeige WNT2 Proteine) signaling.

  3. Sumf1 is indispensable for sulfatase activation in mice and mammals, differently from bacteria, have a single sulfatase modification system

SUMF1 Protein Überblick

Protein Überblick

This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit SUMF1

  • sulfatase modifying factor 1 (SUMF1)
  • sulfatase modifying factor 1 (Sumf1)
  • AA543204 Protein
  • AAPA3037 Protein
  • AI463102 Protein
  • AI851573 Protein
  • FGE Protein

Bezeichner auf Proteinebene für SUMF1

C-alpha-formylglycine-generating enzyme 1 , FGly-generating enzyme , sulfatase-modifying factor 1 , sulfatase-modifying factor

GENE ID SPEZIES
285362 Homo sapiens
58911 Mus musculus
362409 Rattus norvegicus
536435 Bos taurus
484681 Canis lupus familiaris
100514188 Sus scrofa
Ausgewählte Anbieter für SUMF1 Proteine (SUMF1)
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