anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) Antikörper

SPRED2 is a member of the Sprouty (see SPRY1\; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1\; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen SPRED2 Proteine (6) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SPRED2 200734 Q7Z698
SPRED2 114716 Q924S7
SPRED2 305539 Q3C2P8
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Top anti-SPRED2 Antikörper auf antikoerper-online.de

Showing 10 out of 24 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SPRED2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate WB Suggested Anti-SPRED2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HepG2 cell lysate  There is BioGPS gene expression data showing that SPRED2 is expressed in HepG2 100 μL 2 bis 3 Tage
$289.00
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, WB 0.1 mg 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert EIA, WB   0.1 mg 4 bis 8 Tage
$522.50
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged SPRED2 is approximately 1ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg 11 bis 12 Tage
$440.00
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL 11 bis 12 Tage
$305.71
Details
Human Kaninchen Unkonjugiert ELISA, WB 0.1 mg 2 bis 3 Tage
$360.00
Details
Human Kaninchen Unkonjugiert WB   100 μL 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB   100 μg 11 bis 14 Tage
$859.83
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of SPRED2 in human small intestine tissue lysate with SPRED2 polyclonal antibody  at (A) 1 and (B) 2 ug/mL . 100 μg 11 bis 12 Tage
$356.00
Details

Am meisten referenzierte anti-SPRED2 Antikörper

  1. Human Polyclonal SPRED2 Primary Antibody für ELISA, WB - ABIN566938 : Li, Jackson, Yusoff, Guy: Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. in The Journal of biological chemistry 2010 (PubMed)

  2. Human Monoclonal SPRED2 Primary Antibody für ELISA, WB - ABIN566939 : Lock, I, Straffon, Schieb, Hovens, Stylli: Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. in Biochemical and biophysical research communications 2006 (PubMed)

Weitere Antikörper gegen SPRED2 Interaktionspartner

Zebrafish Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) Interaktionspartner

  1. The present study demonstrates the possible role of Spred-2 signalling in cell proliferative phase during the neural repair in the injured zebrafish brain

Human Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) Interaktionspartner

  1. Our findings show that miR-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of Hepatocellular carcinoma (HCC) by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR-487a as a potential prognostic marker or a potential therapeutic target against HCC.

  2. data indicate that Spred2 induces tumor cell death in an autophagy-dependent manner.

  3. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  4. Spred2 was involved in erythroid differentiation of chronic myeloid leukemia cells and participated in imatinib induced erythroid differentiation partly through ERK signaling.

  5. Downregulation of SPRED2 mRNA is associated with prostate cancer.

  6. Data present that galectin-1, ataxin-3 and sprouty-related EVH1 domain-containing protein 2 (SPRED2) may be associated with the progression and development of Down syndrome.

  7. Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with the p85 subunit of phosphatidylinositol 3-kinase.

  8. the knockdown of Spred2 markedly enhanced tumor growth in vivo.

  9. Sprouty and Spred proteins are negative regulators of the ERK/Elk-1 pathway activation induced not only by growth-factors, but also by reactive lipidic mediators.

  10. data in the present study suggests that Spred2 is a regulator of TGF-beta1-induced malignance in transformed keratinocytes

  11. NMR assignment of the human Spred2 EVH1 domain

  12. Spred-2 was found to be strongly expressed in glandular epithelia and, at the subcellular level, its immunoreactivity was associated with secretory vesicles. It becomes most likely that Spred-2 is involved in the regulation of secretory pathways

  13. We show here that Spred-1 and Spred-2 appear to have distinct mechanisms whereby they induce their effects, as the Sprouty domain of Spred-1 is not required to block MAPK (mitogen-activated protein kinase) activation, while that of Spred-2 is required.

  14. Loss of Spred-2 inhibits bone growth in transgenic mice by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway.

  15. reduction of Spred expression in hepatocellular carcinoma (HCC) is one of the causes of the acquisition of malignant features. Thus, Spred could be not only a novel prognostic factor but also a new therapeutic target for human HCC

  16. These results suggest a role for Spred-2 tyrosine phosphorylation and ubiquitination in controlling Spred-2 expression levels.

  17. Linkage analysis of SPRED2 excluded its involvement in Cafe-au-lait spots in a patient with a severe form of Noonan syndrome.

  18. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1.

Mouse (Murine) Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) Interaktionspartner

  1. Spred2-deficiency protects mice from polymicrobial sepsis via increased activation of the ERK/MAPK pathway and subsequent increase in innate immune responses.

  2. Spred2-/- mice developed severer acute liver injury with increased levels of TNFalpha and IL-1beta in the livers.

  3. It is a known inhibitor of ERK1/2 signaling, which influences the severity of lung ischemia reperfusion injury.

  4. Spred2 plays an important role in the regulation of colonic epithelial cell proliferation and inflammation by potentially down-regulating the activation of ERK.

  5. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  6. SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK signaling pathway in pluripotent cells

  7. Spred-2 controls the development of lipopolysaccharide-induced lung inflammation.

  8. Spred-2 negatively regulates APAP-hepatotoxicity under the control of Kupffer cells and NK cells.

  9. Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.

  10. Data show that both SPRED1 and SPRED2 inhibit the ability of DYRK1A to phosphorylate its substrates.

  11. SPRED2 is likely involved in the regulation of dynamic developmental processes.

  12. Spred-2 functions as a negative regulator of aorta-gonad-mesonephros hematopoiesis by inhibiting hematopoietic cytokine signaling.

  13. These data suggest that Spreds are key regulators of RhoA-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.

  14. Spred-1 and Spred-2 were found to be expressed predominantly in brain. It becomes most likely that Spred-2 is involved in the regulation of secretory pathways

  15. We show here that Spred-1 and Spred-2 appear to have distinct mechanisms whereby they induce their effects, as the Sprouty domain of Spred-1 is not required to block MAPK (mitogen-activated protein kinase) activation, while that of Spred-2 is required.

  16. Spred2 is essential for embryonic lymphangiogenesis by regulating VEGFR3 signaling.

  17. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1.

SPRED2 Antigen-Profil

Protein Überblick

SPRED2 is a member of the Sprouty (see SPRY1\; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1\; MIM 176948) (Nonami et al., 2004

Genbezeichner und Symbole assoziert mit SPRED2

  • sprouty related EVH1 domain containing 2 (SPRED2) Antikörper
  • sprouty related, EVH1 domain containing 2 (spred2) Antikörper
  • sprouty-related, EVH1 domain containing 2b (spred2b) Antikörper
  • sprouty related EVH1 domain containing 2 (spred2) Antikörper
  • sprouty-related, EVH1 domain containing 2 (Spred2) Antikörper
  • C79158 Antikörper
  • Spred-2 Antikörper
  • spred2 Antikörper
  • wu:fb93f08 Antikörper
  • Xspred2 Antikörper
  • Xtspred2 Antikörper
  • zgc:77284 Antikörper

Bezeichner auf Proteinebene für SPRED2

sprouty-related, EVH1 domain containing 2 , receptor tyrosine kinase inhibitor protein , sprouty-related, EVH1 domain-containing protein 2 , fb93f08 , spred-2 , sprouty-related protein 2 with EVH-1 domain , sprouty-related, EVH1 domain-containing protein 2-like , sprouty-related protein with EVH-1 domain 2 , sprouty protein with EVH-1 domain 2, related sequence

GENE ID SPEZIES
421271 Gallus gallus
481397 Canis lupus familiaris
496441 Xenopus (Silurana) tropicalis
519081 Bos taurus
697196 Macaca mulatta
793290 Danio rerio
100062947 Equus caballus
100174296 Pongo abelii
100466726 Ailuropoda melanoleuca
100518067 Sus scrofa
459284 Pan troglodytes
100391761 Callithrix jacchus
100562862 Anolis carolinensis
100588144 Nomascus leucogenys
200734 Homo sapiens
114716 Mus musculus
305539 Rattus norvegicus
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