Spermatogenesis and Oogenesis Specific Basic Helix-Loop-Helix 2 Proteine (SOHLH2)

Human Spermatogenesis and Oogenesis Specific Basic Helix-Loop-Helix 2 (SOHLH2) Interaktionspartner

1. sohlh2 functions as a tumor metastasis suppressor via suppressing IL-8 (zeige IL8 Proteine) expression in breast cancer

2. Results identified MMP9 (zeige MMP9 Proteine) as a novel target for transcriptional inactivation by Sohlh2 and demonstrated that the Sohlh2 downregulation of MMP9 (zeige MMP9 Proteine) is critical for inhibiting human ovarian cancer cell invasion.

3. The polymorphisms rs1328626 and rs6563386 of the SOHLH2 gene would be the genetic risk factors for nonobstructive azoospermia in the Chinese population. The SNP rs1328641 might influence testes development in the NOA (zeige DLAT Proteine) patients.

4. Low Sohlh2 expression is associated with ovarian cancer.

5. Our identification of novel variants in the SOHLH2 gene, in women with POF (zeige POF1B Proteine) of both Chinese and Serbian origin, strongly suggests an important role for SOHLH2 in human POF (zeige POF1B Proteine) etiology.

Mouse (Murine) Spermatogenesis and Oogenesis Specific Basic Helix-Loop-Helix 2 (SOHLH2) Interaktionspartner

1. Sohlh1 (zeige SOHLH1 Proteine) and Sohlh2 are essential regulators of oocyte differentiation but do not affect meiosis I.

2. SOHLH2 is critical for the formation of synaptonemal complexes.

3. Sohlh2 may inhibit oocyte apoptosis via c-kit/PI3K/Akt (zeige AKT1 Proteine)/Foxo3a (zeige FOXO3 Proteine) signalling pathway

4. SOHLH1 and SOHLH2 were able to directly and cooperatively repress STRA8 expression in cell lines in vitro through binding to its promoter.

5. Our findings suggest that an SOHLH2/SOHLH1 (zeige SOHLH1 Proteine)/SP1 (zeige SP1 Proteine) ternary complex autonomously and cooperatively regulates Sohlh1 (zeige SOHLH1 Proteine) gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.

6. Effects of BMP4 on mouse primordial follicle growth were assayed by follicle count and TUNEL labeling. The expression of phospho-SMAD1/5/8, Sohlh2, and c-kit were measured by immunohistochemistry, RT-PCR, and Western blotting.

7. SOHLH1 (zeige SOHLH1 Proteine) and SOHLH2 directly stimulate Kit transcription in postnatal spermatogonia, thus activating the signaling involved in spermatogonia differentiation and spermatogenetic progression.

8. Data suggest that a dynamic DNA CpG methylation in Sohlh2 and Figlalpha promoters, but not in the intron and exon sequences, is linked to regulation of gene expression, even though CpG islands are also present in their introns or exons.

9. SOHLH1 (zeige SOHLH1 Proteine) and SOHLH2 suppress genes involved in spermatogonial stem cell maintenance, and induce genes important for spermatogonial differentiation.

10. The expression pattern of SOHLH2 suggests that it may be a critical regulator of early germ cell development.