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Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development (By similarity)..
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No association between SOHLH1 SNPs and azoospermia risk in the Chinese population.
In Chinese and Serbian patients with primary ovarian insufficiency, SOHLH1 was found to be a candidate gene.
Findings indicate that a splice-acceptor site mutation that probably causes a nonfunctional SOHLH1 protein results in nonobstructive azoospermia by the lack of normal spermatogenesis.
Sohlh1 and Lhx8 (zeige LHX8 Proteine) are two germ cell-specific, critical regulators of oogenesis
Sohlh1 and Sohlh2 (zeige SOHLH2 Proteine) are essential regulators of oocyte differentiation but do not affect meiosis I.
SOHLH1 and SOHLH2 were able to directly and cooperatively repress STRA8 expression in cell lines in vitro through binding to its promoter.
Our findings suggest that an SOHLH2 (zeige SOHLH2 Proteine)/SOHLH1/SP1 (zeige SP1 Proteine) ternary complex autonomously and cooperatively regulates Sohlh1 gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.
SOHLH1 and SOHLH2 (zeige SOHLH2 Proteine) directly stimulate Kit transcription in postnatal spermatogonia, thus activating the signaling involved in spermatogonia differentiation and spermatogenetic progression.
SOHLH1 and SOHLH2 (zeige SOHLH2 Proteine) suppress genes involved in spermatogonial stem cell maintenance, and induce genes important for spermatogonial differentiation.
Sohlh1 represents the first testis-specific (zeige AIF1 Proteine) bHLH transcription factor (zeige MSGN1 Proteine) that is essential for spermatogonial differentiation.
Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development (By similarity).
newborn ovary helix loop helix
, spermatogenesis associated 27
, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
, helix-loop-helix protein NOHLH