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The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization.
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SPAG6 and L1TD1 are tumor-specifically methylated in NSCLCs and that DNA methylation is involved in the transcriptional regulation of these genes. Moreover, in vitro as well as in vivo experiments revealed tumor-cell growth suppressing properties of L1TD1 in NSCLC cells.
Study demonstrates that SPAG6 may regulate apoptosis through the TRAIL signal pathway by inhibiting the expression of FADD and the interactions between FADD and the TRAIL death receptors.
studies demonstrate a role for Spag6 in the pathogenesis of OM in mice, possibly through its role in the regulation of cilia/basal body polarity through the PCP (zeige PRCP Proteine)-dependent mechanisms in the middle ear and Eustachian tubes.
These findings demonstrate that SPAG6 might have a role in malignant myeloid hematologic cell proliferation and apoptosis by regulating caspase (zeige CASP3 Proteine) proteins and p53 (zeige TP53 Proteine), suggesting that SPAG6 may be a potential therapeutic target.
SPAG6 is a S-SOX5 (zeige SOX5 Proteine) target gene, indicating a key role for S-SOX5 (zeige SOX5 Proteine) in the formation and function of motile cilia.
Data describe the cloning of human and mouse Pf20 (zeige SPAG16 Proteine) proteins that interact with Spag6 protein.
SPAG6 binds to prestin (zeige SLC26A5 Proteine) in vivo and contributes to fix prestin (zeige SLC26A5 Proteine) biomolecules in lateral plasma membrane of outer hair cells.
Spag6 is essential for sperm flagellar motility and that it is important for the maintenance of the structural integrity of mature sperm. The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia.
Accelerated mortality from hydrocephalus and pneumonia in mice with combined deficiency of Spag6 and Spag16L reveals a functional interrelationship between the two central apparatus proteins.
Spag6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.
axoneme central apparatus protein
, protein PF16 homolog
, sperm flagellar protein
, sperm-associated antigen 6
, axoneme protein
, sperm associated antigen 6