Sperm Associated Antigen 6 Proteine (SPAG6)

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization.

alle Proteine anzeigen Gen GeneID UniProt
Human SPAG6 SPAG6 9576 O75602
Maus SPAG6 SPAG6 50525 Q9JLI7
Ratte SPAG6 SPAG6 360747  
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
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Weitere Proteine zu Sperm Associated Antigen 6 (SPAG6) Interaktionspartnern

Human Sperm Associated Antigen 6 (SPAG6) Interaktionspartner

  1. SPAG6 and L1TD1 are tumor-specifically methylated in NSCLCs and that DNA methylation is involved in the transcriptional regulation of these genes. Moreover, in vitro as well as in vivo experiments revealed tumor-cell growth suppressing properties of L1TD1 in NSCLC cells.

  2. Study demonstrates that SPAG6 may regulate apoptosis through the TRAIL signal pathway by inhibiting the expression of FADD and the interactions between FADD and the TRAIL death receptors.

  3. studies demonstrate a role for Spag6 in the pathogenesis of OM in mice, possibly through its role in the regulation of cilia/basal body polarity through the PCP (zeige PRCP Proteine)-dependent mechanisms in the middle ear and Eustachian tubes.

  4. These findings demonstrate that SPAG6 might have a role in malignant myeloid hematologic cell proliferation and apoptosis by regulating caspase (zeige CASP3 Proteine) proteins and p53 (zeige TP53 Proteine), suggesting that SPAG6 may be a potential therapeutic target.

  5. SPAG6 is a S-SOX5 (zeige SOX5 Proteine) target gene, indicating a key role for S-SOX5 (zeige SOX5 Proteine) in the formation and function of motile cilia.

  6. Data describe the cloning of human and mouse Pf20 (zeige SPAG16 Proteine) proteins that interact with Spag6 protein.

Mouse (Murine) Sperm Associated Antigen 6 (SPAG6) Interaktionspartner

  1. SPAG6 binds to prestin (zeige SLC26A5 Proteine) in vivo and contributes to fix prestin (zeige SLC26A5 Proteine) biomolecules in lateral plasma membrane of outer hair cells.

  2. SPAG6 is a S-SOX5 (zeige SOX5 Proteine) target gene, indicating a key role for S-SOX5 (zeige SOX5 Proteine) in the formation and function of motile cilia.

  3. Spag6 is essential for sperm flagellar motility and that it is important for the maintenance of the structural integrity of mature sperm. The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia.

  4. Data describe the cloning of human and mouse Pf20 (zeige SPAG16 Proteine) proteins that interact with Spag6 protein.

  5. Accelerated mortality from hydrocephalus and pneumonia in mice with combined deficiency of Spag6 and Spag16L reveals a functional interrelationship between the two central apparatus proteins.

  6. Spag6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.

Sperm Associated Antigen 6 (SPAG6) Protein Überblick

Protein Überblick

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SPAG6

  • sperm associated antigen 6 (SPAG6)
  • sperm associated antigen 6-like (Spag6l)
  • sperm associated antigen 6 (Spag6)
  • sperm associated antigen 6 (spag6)
  • sperm associated antigen 6 L homeolog (spag6.L)
  • DKFZp459D035 Protein
  • PF16 Protein
  • repro-sa-1 Protein
  • RGD1310892 Protein
  • SPAG6 Protein
  • zgc:91805 Protein

Bezeichner auf Proteinebene für SPAG6

axoneme central apparatus protein , protein PF16 homolog , sperm flagellar protein , sperm-associated antigen 6 , axoneme protein , sperm associated antigen 6

GENE ID SPEZIES
9576 Homo sapiens
50525 Mus musculus
360747 Rattus norvegicus
420505 Gallus gallus
431757 Danio rerio
450348 Pan troglodytes
477978 Canis lupus familiaris
539424 Bos taurus
548730 Xenopus (Silurana) tropicalis
734748 Xenopus laevis
100134839 Meleagris gallopavo
100174630 Pongo abelii
100286811 Sus scrofa
100724896 Cavia porcellus
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