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The protein encoded by SP8 is an SP family transcription factor that in mouse has been shown to be essential for proper limb development.
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Data suggest expression of transcription factor p8/SP8 is up-regulated in endoplasmic reticulum stress due to lipotoxicity; overexpression of SP8 up-regulates autophagy; autophagy due to lipotoxicity requires SP8; these reactions are mTOR (zeige FRAP1 Antikörper)-independent.
Genetic variants on 3q21 and in the Sp8 transcription factor gene (SP8) as susceptibility loci for psychotic disorders.
This study provided that SP8 are associated with Bipolar I in the Han Chinese population
Sp5 (zeige SP5 Antikörper)/8 bind directly to GC boxes in Wnt (zeige WNT2 Antikörper) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (zeige HNF1A Antikörper)/lymphoid enhancer factor (Lef) 1 (zeige LEF1 Antikörper) to facilitate recruitment of beta-catenin (zeige CTNNB1 Antikörper) to target gene enhancers.
Provide the first direct evidence that a transient Sp8+ interneuron handlebar-like structure exists in the CC during a brief postnatal critical period.
Sp5 (zeige SP5 Antikörper) and Sp8 are pivotal downstream effectors of Wnt3a (zeige WNT3A Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) that are essential for the self-renewal and differentiation of neuromesodermal stem cells.
Our data are compatible with Sp6 and Sp8 working together and in a dose-dependent manner as indispensable mediators of Wnt/betacatenin and Bmp signaling in the limb ectoderm
Findings provide evidence that Sp8 and another transcription factor, COUP-TF1 (zeige NR2F1 Antikörper), mutually repress each other's cortical neuroepithelial expression along the anterior-posterior and dorsoventral axes
The zinc-finger protein Sp8 plays a supplementary role to Pax6 (zeige PAX6 Antikörper) in establishing the pMN (zeige TBCE Antikörper)/p3 domain boundary.
Sp8 is required for normal craniofacial development.
Almost all calretinin (zeige CALB2 Antikörper) and secretagogin (zeige SCGN Antikörper) positive juxtaglomerular neurons are relatively strongly Sp8 positive, whereas none of calbindin (zeige CALB1 Antikörper) positive neurons is Sp8 positive.
Our results suggest that Sp8 is required for the normal production of parvalbumin (zeige PVALB Antikörper)-positive interneurons in the external plexiform layer of the olfactory bulb.
observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates apical ectodermal ridge formation
The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene.
specificity protein 8
, transcription factor Sp8