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The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by SST.
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By unbiased genome-wide DNA methylation (zeige HELLS Proteine) profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR (zeige GHSR Proteine), SST, and ZIC1 (zeige ZIC1 Proteine)) associated with a 3q gain for the detection of cervical (pre)cancer
Somatostatin pancreatic Delta cells (D cells) locations have also been confirmed in animals and human [review].
Remarkably, the cyclic neuroendocrine peptide somatostatin-14 (SST14) was observed to be the most selectively enriched oligomeric Abeta1-42 binder.
This study demonstrated that expression of somatostatin its colocalization with alpha-synuclein in Amygdala in patient with Parkinson disease.
These results suggest that the poly-T repeat sequence polymorphism in the promoter of the SST gene is associated with significant variations of blood pressure and could modulate the risk of hypertension, particularly among women.
High N-terminal prosomatostatin expression is associated with Cardiovascular Disease and Diabetes.
Data show that 6 of 20 primary pancreatic neuroendocrine tumors (PNETs) had positive staining for multiple hormones gastrin (zeige GAST Proteine), insulin (zeige INS Proteine), glucagon (zeige GCG Proteine), and somatostatin, and positive expression of 1 or more hormones was found in 9 of 12 nonfunctioning PNETs [NF-PNETs]) patients.
Patients with chronic pancreatitis were found to have a strong immunohistochemical reaction to somatostatin and changes in the distribution of D cells when compared to healthy patients.
Results suggest that DNA methylation (zeige HELLS Proteine) may be a proximal mechanism for decreased expression of BDNF (zeige BDNF Proteine), SST, and other BDNF (zeige BDNF Proteine)- and GABA-related genes with brain aging and, by extension, for brain disorders in which their expression is decreased
In cancerous colonic mucosa promoter hypermethylation-related SST downregulation may contribute to the uncontrolled cell proliferation.
The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine.
Obesity- and gender-dependent role of endogenous somatostatin and cortistatin (zeige CORT Proteine) in the regulation of endocrine and metabolic homeostasis in mice.
HIV-1 Tat (zeige TAT Proteine) causes cognitive deficits and selective loss of parvalbumin (zeige PVALB Proteine), somatostatin, and neuronal nitric oxide synthase (zeige NOS1 Proteine) expressing hippocampal CA1 (zeige CA1 Proteine) interneuron subpopulations.
Suppressing somatostatin (SOM) neurons enhanced the Excitation and Inhibition underlying size tuning, explaining SOM neurons' role in surround suppression.
dendrite-targeting somatostatin interneurons are critical for a visually induced, context-dependent gamma rhythm in visual cortex.
The results of this study provided the first in vivo evidence that SOM(+) neurons represent a Central Amygdala population that acquires learning-dependent sensory responsiveness during fear conditioning and furthermore reveal an important role of these neurons in gating passive versus active defensive behaviors.
preinspiratory Dbx1 (zeige DBX1 Proteine) neurons are rhythmogenic, inspiratory Dbx1 (zeige DBX1 Proteine)+ and SST+ neurons primarily act to pattern respiratory motor output, and SST+-neuron-mediated pathways and postsynaptic inhibition modulate breathing pattern. I
Endogenous SST and CORT (zeige CORT Proteine) distinctly impact on DMBA-induced mammary gland tumorigenesis , in a manner that is strongly dependent on the metabolic/endocrine milieu (lean vs. obese status).
This study demonstrated that Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles.
Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon (zeige GCG Proteine) mRNA accumulation in pancreatic alpha-cells.
Individuals with genotype AA of somatostatin had significantly lower body height, body length, hip width, and hucklebone width values compared to AG at 1.5 years old
The present study, provides evidence of pro-SST and SST receptor (SSTR1 (zeige SSTR1 Proteine) and 2A) mRNA expression in ocular ciliary epithelium (CE).
The distribution and morphology of neurons containing somatostatin (SOM) was investigated in the amygdala (CA) of the pig.
Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin (zeige GAL Proteine), somatostatin, NPY (zeige NPY Proteine), and VIP (zeige Vip Proteine).
demonstrate diverse neuronal, neuroendocrine, and cardiovascular actions of a somatostatin gene-encoded hormone
Somatostatin directly promoted spontaneous contractions of the circular muscle of macaque intestine via mediation of SSTR2 (zeige SSTR2 Proteine) in myenteric nerve plexus between the longitudinal and the circular muscle.
Helicobacter pylori is capable of inhibiting acid secretion directly as well as indirectly by activating intramural CGRP (zeige CALCA Proteine) sensory neurons coupled to stimulation of SST and inhibition of histamine secretion.
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.
growth hormone release-inhibiting factor
, preprosomatostatin 1a
, somatostatin preproprotein
, somatostatin 1b