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SLC8A3 encodes a member of the sodium/calcium exchanger integral membrane protein family. Zusätzlich bieten wir Ihnen Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal SLC8A3 Primary Antibody für WB - ABIN2781702
Pulina, Rizzuto, Brini, Carafoli: Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. in The Journal of biological chemistry 2006
Show all 2 Pubmed References
These results...suggest that cells can use a dynamic Ca(2 (zeige CA2 Antikörper)+) signaling toolkit in which the NCX3 sub-cellular localization changes in synchrony with the cell cycle
Structure-Dynamic Coupling Through Ca(2 (zeige CA2 Antikörper)+)-Binding Regulatory Domains of Mammalian NCX (zeige TLX2 Antikörper) Isoform/Splice Variants
stimulation of NCX3 by PKA occurred through residue S524. This effect may well participate in the fight-or-flight response in skeletal muscle and the long-term potentiation in hippocampus.
In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA (zeige PRTN3 Antikörper)-positive rheumatoid arthritis at a genome-wide level of significance.
Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain.
NCX1 (zeige SLC8A1 Antikörper) and NCX3 -represent two promising druggable targets for setting on new strategies in stroke therapy.
NCX (zeige TLX2 Antikörper) isoforms (NCX2 (zeige SLC8A2 Antikörper), NCX3) contribute to mitochondrial Na(+)/Ca(2 (zeige CA2 Antikörper)+) exchange in human DAergic neurons and may act downstream of PINK1 (zeige PINK1 Antikörper) in the prevention of neurodegeneration by m[Ca(2 (zeige CA2 Antikörper)+)] accumulation.
the large cytosolic loop of NCX1 (zeige SLC8A1 Antikörper), NCX2 (zeige SLC8A2 Antikörper), and NCX3 is involved in acquisition of immunosuppressive drug specificity
Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 (zeige SLC8A1 Antikörper) and NCX3, but not NCX2 (zeige SLC8A2 Antikörper), were divergently modulated during OPC differentiation into oligodendrocyte.
human macrophages and monocytes express NCX1 (zeige SLC8A1 Antikörper) and NCX3 that operate in a bidirectional manner to restore [Ca(2 (zeige CA2 Antikörper)+)](i) to generate Ca(2 (zeige CA2 Antikörper)+) signals and to induce TNF-alpha (zeige TNF Antikörper) production.
This study demonstrate that knocking-out NCX3 impairs oligodendrocyte response and worsens clinical symptoms in EAE without altering the immune T-cell population.
Demonstrate that NCX3 genetic deletion protects against ziram-induced neurotoxicity and suggest NCX3 and its downstream molecular pathways as key factors involved in ziram toxicity.
NCX3 regulates mitochondrial calcium handling from the outer mitochondrial membrane through an AKAP121 (zeige AKAP1 Antikörper)-anchored signaling complex.
Function and regulation of the Na+-Ca2+ exchanger (zeige SLC8A1 Antikörper) NCX3 splice variants in brain and skeletal muscle.
the use of genetic-modified mice for NCX1 (zeige SLC8A1 Antikörper), NCX2 (zeige SLC8A2 Antikörper), and NCX3 represents a fruitful strategy to characterize the physiological role exerted by NCX (zeige SLC8A1 Antikörper) in CNS
the solution structure of NCX3 calcium binding domain 2B
calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation.
Results show that glucocorticoid treatment blunts LPS (zeige TLR4 Antikörper)-induced increase in [Ca(2 (zeige CA2 Antikörper)+)](i) in dendritic cells by increasing expression and activity of Na(+)/Ca(2 (zeige CA2 Antikörper)+) exchanger NCX3.
The deletion of the NCX3 gene has detrimental consequences on basal synaptic transmission, long term potentiation regulation, spatial learning, and memory performance.
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.
solute carrier family 8 (sodium-calcium exchanger), member 3
, solute carrier family 8 member 3
, solute carrier family 8 (sodium/calcium exchanger), member 3
, sodium/calcium exchanger 3-like
, Na(+)/Ca(2+)-exchange protein 3
, Na+/Ca2+ exchanger 3
, sodium/calcium exchanger 3
, sodium/calcium exchanger SLC8A3
, sodium-calcium exchanger