Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteine (SLC6A4)

SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Zusätzlich bieten wir Ihnen Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antikörper (107) und Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (55) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC6A4 15567 Q60857
SLC6A4 6532 P31645
SLC6A4 25553 P31652
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Top Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteine auf antikoerper-online.de

Showing 7 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human GST tag,S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
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Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$653.82
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Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$724.89
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SLC6A4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Human , , ,
, , ,
Rat (Rattus)

Am meisten referenzierte Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteine

  1. Human SLC6A4 Protein expressed in HEK-293 Cells - ABIN2732177 : Savy, Fitchett, McQuade, Gartside, Morris, Blain, Judge: Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour. in Neurotoxicology 2015 (PubMed)

Weitere Proteine zu Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism

  2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

  3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (zeige DDC Proteine) storage, and potentially for function of dSERT.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin (zeige NDN Proteine)-knockout pups.

  2. Adrenal glands from wild-type mice contained 5-HT (zeige DDC Proteine) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (zeige HTR1A Proteine) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (zeige DDC Proteine) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

  3. These data suggest that correlated expression of Slc6a4 and Htr4 (zeige HTR4 Proteine) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (zeige GUSB Proteine).

  4. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

  5. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

  6. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

  7. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (zeige DDC Proteine) contributions of drug actions in vivo.

  8. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

  9. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD (zeige GUSB Proteine) and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD (zeige GUSB Proteine).

  10. SERT protects trophoblast cells against apoptotic cell death in caspase-3 (zeige CASP3 Proteine) independent pathway by terminating the 5-HT (zeige DDC Proteine) signaling.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. This paper contains kinetics data of serotonin receptor (zeige HTR1B Proteine) binding.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. Rhesus monkeys carrying the short rh5 (zeige RHO Proteine)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

  2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

  3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

  4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (zeige HTR1A Proteine) site is found in animals possessing this polymorphism.

  5. We find that the short allele of the rh5 (zeige RHO Proteine)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

  6. rh5 (zeige RHO Proteine)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

  7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

  8. carriers of the low-expressing rh5 (zeige RHO Proteine)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

  9. evidence that the short allelic variant in rh5 (zeige RHO Proteine)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

  10. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. Study applied graph theory analysis on resting-state fMRI of 120 women selected based on neuroticism score, & genotyped 2 polymorphisms: 5-HTTLPR (S-carriers and L-homozygotes) and COMT (zeige COMT Proteine) (rs4680-rs165599; COMT (zeige COMT Proteine) risk group and COMT (zeige COMT Proteine) non-risk group). For the 5-HTTLPR polymorphism, found that subnetworks related to cognitive control show less connections with other subnetworks in S-carriers compared to L-homozygotes.

  2. The nursing diagnoses of risk for suicide and imbalanced nutrition are reported less often in 5-HTTLPR homozygotes of the high-expressing gene (LA). Carriers of the low-expressing genes (LG or S) have a worse response to interventions which aim to increase low self-esteem, indicating that they may need more intensive care in order to achieve the desired outcome.

  3. Pilot study demonstrated an increase in the SLC6A4 promoter DNA methylation (zeige HELLS Proteine) levels in the saliva (zeige RAG1AP1 Proteine) of children and adolescents with obsessive-compulsive disorder. DNA methylation (zeige HELLS Proteine) provides one important epigenetic mechanism through which environmental influences can affect psychiatric disease risk.

  4. genetic association studies in population in Spain: Data suggest genetic polymorphisms in SLC6A4 promoter region are associated with ability to control food intake in overweight/obese subjects while in weight loss programs; SLC6A4 promoter polymorphisms interact with emotional eating to modulate weight loss. The biggest challenge for losing weight is the ability to control the amount of food eaten.

  5. findings suggest that the 5-HTTLPR S allele is associated with lower BMD (zeige BEST1 Proteine) in adults younger than 50 years

  6. Depression remitted 5-HTTLPR S/Lg-carriers who experienced childhood trauma automatically avoided sad facial expressions relatively more than LaLa homozygotes with childhood trauma. Remitted LaLa-carriers who had not experienced childhood trauma, avoided sad faces relatively more than LaLa homozygotes with childhood trauma. Study did not find a main effect of childhood trauma.

  7. In a study of the genetic association between polymorphisms in the DAT1, SERT, COMT (zeige COMT Proteine) and BDNF (zeige BDNF Proteine) genes and attention deficit and hyperactive disorder, transmission disequilibrium test analysis showed that no individual allele of any variant studied has a preferential transmission

  8. Participants who assessed themselves with greater interdependence reported lower death anxiety/depression and showed decreased neural response to death-related words in emotion-related brain regions including the anterior cingulate, putamen, and thalamus. However, these results were evident in long/long allele carriers of the 5-HTTLPR but not in short/short allele carriers.

  9. 5-HTTLPR S-allele carriers showed a more negative relation between stress exposure and connectivity of the executive control network than L-allele homozygotes, specifically in the pre/postcentral gyrus, striatum, and frontal pole. In the default mode network, found a positive association between the GxE and supramarginal gyrus connectivity.

  10. Study found a significant interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Mean connectivity in the right inferior parietal lobule was positively correlated with working memory performance.

Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Protein Überblick

Protein Überblick

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Genbezeichner und Symbole assoziert mit SLC6A4

  • Serotonin transporter (SerT)
  • solute carrier family 6 member 4 (SLC6A4)
  • huntingtin (LOC100540532)
  • solute carrier family 6 member 4 (slc6a4)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4)
  • solute carrier family 6 member 4 (Slc6a4)
  • 5-HTT Protein
  • 5-HTTLPR Protein
  • 5HTT Protein
  • AI323329 Protein
  • CG4545 Protein
  • Dmel\\CG4545 Protein
  • DmSerT Protein
  • dsert Protein
  • dSERT1 Protein
  • hSERT Protein
  • Htt Protein
  • OCD1 Protein
  • Sert Protein
  • SERT1 Protein
  • SLC6A4 Protein

Bezeichner auf Proteinebene für SLC6A4

serotonin transporter , CG4545-PA , SerT-PA , drosophila serotonin transporter , cocaine-sensitive serotonin transporter , sodium-dependent serotonin transporter , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , solute carrier family 6 member 4 , sodium-dependent serotonin transporter-like , huntingtin , plasma membrane transporter for serotonin reuptake , 5-hydroxytryptamine (serotonin) transporter , 5HT transporter , 5HTT , Sodium-dependent serotonin transporter (5HT transporter) (5HTT) , transmembrane 5-HT transporter , 5-hydroxytryptamine transporter , Na+/Cl- dependent serotonin transporter , serotonin transporter 1 , Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6, member 4 , serotnin transporter

GENE ID SPEZIES
37895 Drosophila melanogaster
404747 Gallus gallus
468201 Pan troglodytes
100340600 Oryctolagus cuniculus
100396167 Callithrix jacchus
100435954 Pongo abelii
100540532 Meleagris gallopavo
100562250 Anolis carolinensis
100596376 Nomascus leucogenys
443491 Ovis aries
15567 Mus musculus
282365 Bos taurus
100135619 Cavia porcellus
574140 Macaca mulatta
6532 Homo sapiens
25553 Rattus norvegicus
491184 Canis lupus familiaris
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