Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteine (SLC6A4)

SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Zusätzlich bieten wir Ihnen Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antikörper (109) und Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (55) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC6A4 6532 P31645
SLC6A4 15567 Q60857
SLC6A4 25553 P31652
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Top Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteine auf

Showing 7 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human GST tag,S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage

SLC6A4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus)

Am meisten referenzierte Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteine

  1. Human SLC6A4 Protein expressed in HEK-293 Cells - ABIN2732177 : Savy, Fitchett, McQuade, Gartside, Morris, Blain, Judge: Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour. in Neurotoxicology 2015 (PubMed)

Weitere Proteine zu Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartnern

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. Influence of polymorphic variants of the SLC6A4 gene on the frequency of detection of depressive states in the group of the first responders of Chornobyl accident in the remote period after the Chornobyl catastrophe has been reported.

  2. The miRNA-424 expression increased whereas SERT expression decreased in the patients' mucosa. Similarly, incubation of the epithelial cell line with inflammatory cytokines resulted in increased miRNA-424 and decreased SERT mRNA and protein expression. The miRNA expression and processing are augmented in the inflamed intestinal mucosa of patients with pouchitis.

  3. Individuals resilient to seasonal affective disorder (SAD) underwent PET imaging with 11C-DASB- and 11C-SB207145 both summer and winter to measure SERT and 5-HT4 R binding. Study did not observe changes in 5-HT4R binding, suggesting that 5-HT levels remained stable across seasons. Resilience to SAD is associated with a global downregulation of SERT levels in winter which serves to keep 5-HT levels across seasons.

  4. In the sample population, no significant association was found between lifelong premature ejaculation and polymorphisms in the SLC6A4 gene.

  5. Childhood trauma and 5-HTTLPR genotype seem to be independently involved in suicide attempts, sharing a common pathway of increasing impulsivity.

  6. 5-HTTLPR polymorphism has been associated with the risk of developing alcohol dependence.

  7. Study results provide a comprehensive direct view of the conformational response of SERT upon binding both biologically relevant substrate/ions and ligands of pharmaceutical interest, thus advancing understanding of the structure-function relationship in SERT.

  8. A main finding in the study was serotonin transporter (SERT) binding in the brain was lower in suicides independent of sex, but dependent on major depression diagnosis; higher SERT binding is associated with alcohol use disorder.

  9. Higher frequency of D allele in convicted offenders and MMA fighters than in the general male population; higher frequencies of D/D and 12/12 genotype combinations were shown to be higher in convicts, especially, in habitual criminals and those convicted of grave crimes or murder.

  10. pilot study did not support the supposed association between 5-HTTLPR and completed suicides or with violent completed suicides

  11. Evidence suggests an association between the 5-HTTLPR and violent suicidal behavior (meta-analysis).

  12. did not find statistically significant differences between individuals carrying at least one S allele between the depression and healthy control subjects, or among the mother-child pair groups with different patterns of occurrence of depression.

  13. There was a significant difference in the allele distribution of 5-HTTLPR between the oppositional defiant disorder and control groups in a Chinese Han population.

  14. SLC6A4 methylation was found to be significantly higher in women when compared to men independent of DSM-IV diagnosis. SLC6A4 methylation was further associated with the Brief Symptom Inventory-derived somatization dimension.

  15. Systematic review and meta-analysis The present study supported the presence of a marginal but detectable effect of the 5-HTTLPR on susceptibility to bipolar disorder (BPD). Moreover, the detected association in Caucasian was statistically reliable. Besides, the 5-HTTLPR was identified as a useful predictor for anti-depressive remission but not for anti-depressive or anti-manic response.

  16. For s-allele carriers only, caregiver-reported peer problems at age 4 predict more parent-reported hyperactivity-impulsivity symptoms at age 6.

  17. Study provides evidence for an association of 5-HTTLPR genotype with risk-seeking for losses, independent of acute 5-HT levels.

  18. The heterozygous SL for 5-HTTLPR SNP was significantly correlated with protection against progression to DHF in the codominant SS/SL/LL (OR=0.22, 95% CI=0.06-0.81, p=0.011) and overdominant models SL vs SS+LL (OR=0.19, 95% CI=0.06-0.65, p=0.003).

  19. The presence of the high expression SERT genotype (LALA) may be associated with a lower risk of ischemic stroke/TIA.

  20. The adjusted model indicates that this association is not mediated or moderated by impulsivity. CONCLUSION: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. Study is the first demonstration of a quantitative in vivo evaluation of serotonin transporter (SERT) density in subregions of the mouse brain using [11C]DASB-PET.

  2. altered 5-HT reuptake due to the downregulation of SERT, together with enterochromaffin cell hyperplasia, are the underlying mechanisms of increased 5-HT availability in Winnie mice

  3. amyloid- and tau-associated lesions were observed in the midbrain raphe of 12 month old APPswe/PS1dE9 mice. SERT binding levels were reduced in transgenic animals compared to age-matched controls, and SERT mRNA levels were decreased by at least 50% from control values. Intense microglial, but not astrocytic immunoreactivity was observed in APPswe/PS1dE9 vs. wild-type mice.

  4. we propose a generalized epigenetic mechanism behind the development of ASD-like characteristics in embryos developing in Slc6a4 +/- dams exposed to prenatal stress.

  5. Restulsshow that peripheral inflammation causes specific molecular changes in the hippocampus of collagen-induced arthritis (CIA) mice, including an upregulation of SERT activity and an increase in TNFalpha signalling. TNFalpha blockade abolished both, CIA-induced anhedonia and the upregulation of SERT activity in etanercept treated mice; behavioural and neurochemical effects in CIA mice are dependent on TNFalpha signa...

  6. Social deficits were observed in heterozygous and homozygous Sert knockout mice.

  7. Slc6a4 mutations affect neuroanatomy in 5-HT relevant brain regions assessed by MRI.

  8. Together, these findings support that estrogen suppression is involved in SERT deficiency-induced obesity and glucose intolerance, and suggest approaches to restore 17beta-estradiol levels as a novel treatment option for SERT deficiency associated obesity and metabolic abnormalities.

  9. NOD2 could play a role in intestinal pathophysiology not only through its inherent innate immune role but also due to its interaction with other receptors as TLR2 and the modulation of the intestinal serotonergic system decreasing SERT activity and expression.

  10. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin-knockout pups.

  11. Adrenal glands from wild-type mice contained 5-HT at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

  12. These data suggest that correlated expression of Slc6a4 and Htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut.

  13. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

  14. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

  15. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

  16. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT contributions of drug actions in vivo.

  17. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

  18. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD.

  19. SERT protects trophoblast cells against apoptotic cell death in caspase-3 independent pathway by terminating the 5-HT signaling.

  20. Variant Ala56-expressing mice display GI defects that resemble those seen in mice lacking neuronal 5-HT. These defects included enteric nervous system hypoplasia, slow GI transit, diminished peristaltic reflex activity, and proliferation of crypt epithelial cells.

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism

  2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

  3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT storage, and potentially for function of dSERT.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. The findings provide, to the author's knowledge, the first empirical support for the assertion that the s-allele grants high undirected biological sensitivity to context in primates and suggest a mechanism through which the 5-HTTLPR s-allele is maintained in primate populations.

  2. Rhesus monkeys carrying the short rh5-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

  3. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

  4. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

  5. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor site is found in animals possessing this polymorphism.

  6. We find that the short allele of the rh5-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

  7. rh5-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

  8. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

  9. We thus reject a role for this particular polymorphism in interspecific behavioural variability and show that polymorphic species enjoy greater ecological success possibly due to their higher intraspecific variability in individual behavioural traits.

  10. carriers of the low-expressing rh5-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

  11. evidence that the short allelic variant in rh5-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

  12. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

  13. Linked to chromosome 16 in macaca mulatta.

  14. Substance abuse of cocaine leads to alterations in serotin transporter function in brain areas relevant to drug abuse.

  15. Data sho wthat genotype (serotonin transporter promoter) acted independently in interaction with social condition to affect behavioral responses.

  16. Adult female rhesus monkeys with the s-variant polymorphism in the SERT gene exhibit metabolic and reproductive alterations.

  17. data suggest that polymorphisms in the gene encoding the serotonin transporter modulate the adverse consequences of social subordination on the timing of puberty in female rhesus monkeys

  18. This study suggests that genetic factors modify the responses of monkeys to social subordination and perhaps other psychosocial stressors.

  19. length polymorphisms in 5-HTTLPR predict social reward and punishment

  20. polymorphisms in the SLC6A4 gene may contribute to differences in reproductive compromise in response to chronic stress.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

  1. This paper contains kinetics data of serotonin receptor binding.

Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Protein Überblick

Protein Überblick

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Genbezeichner und Symbole assoziert mit SLC6A4

  • solute carrier family 6 member 4 (SLC6A4)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4)
  • solute carrier family 6 member 4 (Slc6a4)
  • Serotonin transporter (SerT)
  • huntingtin (LOC100540532)
  • solute carrier family 6 member 4 (slc6a4)
  • solute carrier family 6 (neurotransmitter transporter), member 4a (slc6a4a)
  • 5-HTT Protein
  • 5-HTTLPR Protein
  • 5HTT Protein
  • AI323329 Protein
  • CG4545 Protein
  • Dmel\\CG4545 Protein
  • DmSerT Protein
  • dsert Protein
  • dSERT1 Protein
  • hSERT Protein
  • Htt Protein
  • OCD1 Protein
  • Sert Protein
  • SERT1 Protein
  • SLC6A4 Protein

Bezeichner auf Proteinebene für SLC6A4

5-hydroxytryptamine (serotonin) transporter , 5-hydroxytryptamine transporter , 5HT transporter , Na+/Cl- dependent serotonin transporter , serotonin transporter 1 , sodium-dependent serotonin transporter , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , 5HTT , Sodium-dependent serotonin transporter (5HT transporter) (5HTT) , solute carrier family 6 member 4 , Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , serotonin transporter , solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6, member 4 , CG4545-PA , SerT-PA , drosophila serotonin transporter , cocaine-sensitive serotonin transporter , plasma membrane transporter for serotonin reuptake , transmembrane 5-HT transporter , sodium-dependent serotonin transporter-like , huntingtin , serotnin transporter , serotonin transporter a , serta , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A

6532 Homo sapiens
15567 Mus musculus
25553 Rattus norvegicus
37895 Drosophila melanogaster
443491 Ovis aries
574140 Macaca mulatta
282365 Bos taurus
404747 Gallus gallus
468201 Pan troglodytes
100135619 Cavia porcellus
100340600 Oryctolagus cuniculus
100396167 Callithrix jacchus
100435954 Pongo abelii
100540532 Meleagris gallopavo
100562250 Anolis carolinensis
100596376 Nomascus leucogenys
491184 Canis lupus familiaris
664719 Danio rerio
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