Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) ELISA Kits

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism

2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (zeige DDC ELISA Kits) storage, and potentially for function of dSERT.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin (zeige NDN ELISA Kits)-knockout pups.

2. Adrenal glands from wild-type mice contained 5-HT (zeige DDC ELISA Kits) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (zeige HTR1A ELISA Kits) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (zeige DDC ELISA Kits) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

3. These data suggest that correlated expression of Slc6a4 and Htr4 (zeige HTR4 ELISA Kits) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (zeige GUSB ELISA Kits).

4. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

5. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

6. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

7. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (zeige DDC ELISA Kits) contributions of drug actions in vivo.

8. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

9. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD (zeige GUSB ELISA Kits) and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD (zeige GUSB ELISA Kits).

10. SERT protects trophoblast cells against apoptotic cell death in caspase-3 (zeige CASP3 ELISA Kits) independent pathway by terminating the 5-HT (zeige DDC ELISA Kits) signaling.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. This paper contains kinetics data of serotonin receptor (zeige HTR1B ELISA Kits) binding.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Rhesus monkeys carrying the short rh5 (zeige RHO ELISA Kits)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (zeige HTR1A ELISA Kits) site is found in animals possessing this polymorphism.

5. We find that the short allele of the rh5 (zeige RHO ELISA Kits)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

6. rh5 (zeige RHO ELISA Kits)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

8. carriers of the low-expressing rh5 (zeige RHO ELISA Kits)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

9. evidence that the short allelic variant in rh5 (zeige RHO ELISA Kits)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

10. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Functional network-based phenotype links genetic variation in 5-HTTLPR to emotion regulation.

2. These findings indicate that TPH1 (zeige TPH1 ELISA Kits), TPH2 (zeige TDO2 ELISA Kits), and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants.

3. This study found that the SLC6A4 hyper-methylation and hypo-expression was found in healthy subjects with childhood trauma.

4. resilience fully mediated the association between the S 5-HTTLPR allele and depression in the medically ill.

5. Study applied graph theory analysis on resting-state fMRI of 120 women selected based on neuroticism score, & genotyped 2 polymorphisms: 5-HTTLPR (S-carriers and L-homozygotes) and COMT (zeige COMT ELISA Kits) (rs4680-rs165599; COMT (zeige COMT ELISA Kits) risk group and COMT (zeige COMT ELISA Kits) non-risk group). For the 5-HTTLPR polymorphism, found that subnetworks related to cognitive control show less connections with other subnetworks in S-carriers compared to L-homozygotes.

6. The nursing diagnoses of risk for suicide and imbalanced nutrition are reported less often in 5-HTTLPR homozygotes of the high-expressing gene (LA). Carriers of the low-expressing genes (LG or S) have a worse response to interventions which aim to increase low self-esteem, indicating that they may need more intensive care in order to achieve the desired outcome.

7. Pilot study demonstrated an increase in the SLC6A4 promoter DNA methylation levels in the saliva of children and adolescents with obsessive-compulsive disorder. DNA methylation provides one important epigenetic mechanism through which environmental influences can affect psychiatric disease risk.

8. genetic association studies in population in Spain: Data suggest genetic polymorphisms in SLC6A4 promoter region are associated with ability to control food intake in overweight/obese subjects while in weight loss programs; SLC6A4 promoter polymorphisms interact with emotional eating to modulate weight loss. The biggest challenge for losing weight is the ability to control the amount of food eaten.

9. findings suggest that the 5-HTTLPR S allele is associated with lower BMD in adults younger than 50 years

10. Depression remitted 5-HTTLPR S/Lg-carriers who experienced childhood trauma automatically avoided sad facial expressions relatively more than LaLa homozygotes with childhood trauma. Remitted LaLa-carriers who had not experienced childhood trauma, avoided sad faces relatively more than LaLa homozygotes with childhood trauma. Study did not find a main effect of childhood trauma.