Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) ELISA Kits

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. The results of this study showed that the baseline level and the changes in SLC6A4 mRNA expression during a Major disorder might predict the suicidal ideation and the occurrence of suicidal attempts and could be a useful biomarker in clinical practice.

2. This study demonstrated that the 5-HTTLPR and a serotonergic multi-marker score effect on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort.

3. Genetic susceptibility to stress conferred by SLC6A4 appeared to modulate unconstrained cognitive flexibility during psychosocial stress in this exploratory sample. If confirmed, this finding may have implications for conditions associated with increased stress response, including performance anxiety and cocaine withdrawal.

4. Study found that in a Japanese population with the s/s genotype of 5-HTTLPR, there was a volume reduction of the insula in the early stages of major depressive disorder patients compared with healthy subjects.

5. Data suggest that SERT exhibits strong binding of cholesterol to CHOL1 (conserved cholesterol site 1) in a membrane bilayer environment; mutations in CHOL1 with negative impact on cholesterol binding induce a more inward-facing conformation, and, vice versa, mutations with positive impact on cholesterol binding induce a more outward-facing conformation.

6. A polymorphism (rs6354), in the 5-HTT gene, was found to influence job-related stress and burnout in healthcare workers in a Chinese hospital.

7. platelet 5-HT content and SERT as peripheral surrogates in depression and anxiety patients

8. The relationship between bullying and pain was modified by genetic variation in the promotor region of SLC6A4. Study data indicated that the effect of bullying on health and well-being is dependent on a gene-environment interaction.

9. This study showed an interaction exists in which the S allele of 5-HTTLPR increases risk of depression only in stressed individuals.

10. STin2 VNTR polymorphism of SLC6A4 gene may contribute to Crohn's disease pathogenesis.

11. 5HTTLPR and dating violence victimization interact to increase odds of marijuana use.

12. ECs derived miR-195 acts as a new regulator to modulate the expression of 5-HTT in SMCs.

13. rs591323 had the effect on SERT availability of pons in healthy male subjects, not in female subjects. SERT availability of AA genotype of rs591323 was lower than those of the other 2 genotypes. However, SNPs of risk loci for Parkinson's disease did not show any effect on DAT availability.

14. platelet BDNF and SERT do not specifically underlie psychosocial deficits in stage Huntington's Disease

15. SLC6A4 l/l carriers have a better ability to perceive and focus their attention on the elements of their environment and to have the capacity to understand and predict what will happen with those elements.

16. 5-HTTLPR's variant moderates Adolescent Substance Misuse Initiation.

17. High serotonin and SERT levels may indicate that these biomarkers have a role in the autism pathogenesis and support the possibility of using serotonin and SERT to diagnose autism severity

18. Findings indicated that the SERT insertion/deletion polymorphism may serve as a genetic biomarker of irritable bowel syndrome in Asians and Caucasians. [meta-analysis]

19. results showing strong associations of childhood neglect and abuse and significant effects of the low-expressing alleles (S; L G ) of 5-HTTLPR with alexithymia.

20. Alcohol use may be positively related, at least cross-sectionally, to depressive symptoms in female carriers of the 5-HTTLPR S allele, and indicate that moderators such as SLC6A4 genotype and sex need to be taken into account when examining associations between depressive symptoms and drinking behavior.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Social deficits were observed in heterozygous and homozygous Sert knockout mice.

2. Slc6a4 mutations affect neuroanatomy in 5-HT relevant brain regions assessed by MRI.

3. Together, these findings support that estrogen suppression is involved in SERT deficiency-induced obesity and glucose intolerance, and suggest approaches to restore 17beta-estradiol levels as a novel treatment option for SERT deficiency associated obesity and metabolic abnormalities.

4. NOD2 could play a role in intestinal pathophysiology not only through its inherent innate immune role but also due to its interaction with other receptors as TLR2 and the modulation of the intestinal serotonergic system decreasing SERT activity and expression.

5. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin-knockout pups.

6. Adrenal glands from wild-type mice contained 5-HT at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

7. These data suggest that correlated expression of Slc6a4 and Htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut.

8. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

9. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

10. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

11. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT contributions of drug actions in vivo.

12. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

13. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD.

14. SERT protects trophoblast cells against apoptotic cell death in caspase-3 independent pathway by terminating the 5-HT signaling.

15. Variant Ala56-expressing mice display GI defects that resemble those seen in mice lacking neuronal 5-HT. These defects included enteric nervous system hypoplasia, slow GI transit, diminished peristaltic reflex activity, and proliferation of crypt epithelial cells.

16. This study showed that the decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter.

17. Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation

18. Data show that SERT associates with ASCT2 (alanine-serine-cysteine-threonine 2), a member of the solute carrier 1 family co-expressed with SERT in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane.

19. In mice, SERT expression was suppressed in inflamed mucosa and continuously observed with low-grade mucosal inflammation during colitis healing.

20. these data demonstrate that sustained SERT loss of function reduces 5-HT2AR surface expression that is critical for the synergistic activation of alphaIIbbeta3 by 5-HT and ADP.

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism

2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT storage, and potentially for function of dSERT.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Rhesus monkeys carrying the short rh5-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor site is found in animals possessing this polymorphism.

5. We find that the short allele of the rh5-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

6. rh5-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

8. We thus reject a role for this particular polymorphism in interspecific behavioural variability and show that polymorphic species enjoy greater ecological success possibly due to their higher intraspecific variability in individual behavioural traits.

9. carriers of the low-expressing rh5-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

10. evidence that the short allelic variant in rh5-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

11. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

12. Linked to chromosome 16 in macaca mulatta.

13. Substance abuse of cocaine leads to alterations in serotin transporter function in brain areas relevant to drug abuse.

14. Data sho wthat genotype (serotonin transporter promoter) acted independently in interaction with social condition to affect behavioral responses.

15. Adult female rhesus monkeys with the s-variant polymorphism in the SERT gene exhibit metabolic and reproductive alterations.

16. data suggest that polymorphisms in the gene encoding the serotonin transporter modulate the adverse consequences of social subordination on the timing of puberty in female rhesus monkeys

17. This study suggests that genetic factors modify the responses of monkeys to social subordination and perhaps other psychosocial stressors.

18. length polymorphisms in 5-HTTLPR predict social reward and punishment

19. polymorphisms in the SLC6A4 gene may contribute to differences in reproductive compromise in response to chronic stress.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. This paper contains kinetics data of serotonin receptor binding.