Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) ELISA Kits

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. results showing strong associations of childhood neglect and abuse and significant effects of the low-expressing alleles (S; L G ) of 5-HTTLPR with alexithymia.

2. Alcohol use may be positively related, at least cross-sectionally, to depressive symptoms in female carriers of the 5-HTTLPR S allele, and indicate that moderators such as SLC6A4 genotype and sex need to be taken into account when examining associations between depressive symptoms and drinking behavior.

3. The SERT gene promoter SNP rs25531 was associated with the cancer-related fatigue in patients with colon and rectal cancer

4. No differences were found between murderers and thieves either concerning 5HTTLPR and 5-HT2C genotypes or concerning psychological measures. Comparison of polymorphism distribution between groups of prisoners and controls revealed highly significant associations of 5HTTLPR and 5-HTR2C (rs6318) gene polymorphisms with being convicted for criminal behavior.

5. Significant association was observed between the S/S genotype of the SLC6A4 polymorphism and globus pharyngeus, suggesting that SLC6A4 is a potential candidate gene involved in the pathogenesis of globus pharyngeus.

6. Association of SLC6A4 variants with familial form of OCD.

7. 5-HTTLPR genotype was associated with traffic behaviour: The S'-allele carriers had significantly lower odds for speeding offences and traffic accidents. The lower prevalence of S'-allele carriers among those who had committed speeding offences was statistically significant in females, while the lower prevalence of having been involved in a traffic accident was rather observed in males.

8. In the present study we systematically investigated the contribution of SNPs toward Social anxiety disorder by performing genotyping of 24 SNPs that have been reported previously in SAD or other psychiatric disorders. This showed an association between rs140701 at SLC6A4 and SAD, especially in Social anxiety disorder patients without panic disorder.

9. Functional network-based phenotype links genetic variation in 5-HTTLPR to emotion regulation.

10. These findings indicate that TPH1 (zeige TPH1 ELISA Kits), TPH2 (zeige TDO2 ELISA Kits), and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Together, these findings support that estrogen suppression is involved in SERT deficiency-induced obesity and glucose intolerance, and suggest approaches to restore 17beta-estradiol levels as a novel treatment option for SERT deficiency associated obesity and metabolic abnormalities.

2. NOD2 (zeige NOD2 ELISA Kits) could play a role in intestinal pathophysiology not only through its inherent innate immune role but also due to its interaction with other receptors as TLR2 and the modulation of the intestinal serotonergic system decreasing SERT activity and expression.

3. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin (zeige NDN ELISA Kits)-knockout pups.

4. Adrenal glands from wild-type mice contained 5-HT (zeige DDC ELISA Kits) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (zeige HTR1A ELISA Kits) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (zeige DDC ELISA Kits) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

5. These data suggest that correlated expression of Slc6a4 and Htr4 (zeige HTR4 ELISA Kits) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (zeige GUSB ELISA Kits).

6. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

7. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

8. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

9. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (zeige DDC ELISA Kits) contributions of drug actions in vivo.

10. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism

2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (zeige DDC ELISA Kits) storage, and potentially for function of dSERT.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Rhesus monkeys carrying the short rh5 (zeige RHO ELISA Kits)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (zeige HTR1A ELISA Kits) site is found in animals possessing this polymorphism.

5. We find that the short allele of the rh5 (zeige RHO ELISA Kits)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

6. rh5 (zeige RHO ELISA Kits)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

8. carriers of the low-expressing rh5 (zeige RHO ELISA Kits)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

9. evidence that the short allelic variant in rh5 (zeige RHO ELISA Kits)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

10. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. This paper contains kinetics data of serotonin receptor (zeige HTR1B ELISA Kits) binding.