Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) ELISA Kits

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

2. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (zeige DDC ELISA Kits) storage, and potentially for function of dSERT.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Adrenal glands from wild-type mice contained 5-HT (zeige DDC ELISA Kits) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (zeige HTR1A ELISA Kits) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (zeige DDC ELISA Kits) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

2. These data suggest that correlated expression of Slc6a4 and Htr4 (zeige HTR4 ELISA Kits) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (zeige GUSB ELISA Kits).

3. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

4. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

5. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

6. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (zeige DDC ELISA Kits) contributions of drug actions in vivo.

7. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

8. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD (zeige GUSB ELISA Kits) and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD (zeige GUSB ELISA Kits).

9. SERT protects trophoblast cells against apoptotic cell death in caspase-3 (zeige CASP3 ELISA Kits) independent pathway by terminating the 5-HT (zeige DDC ELISA Kits) signaling.

10. Variant Ala56-expressing mice display GI defects that resemble those seen in mice lacking neuronal 5-HT (zeige DDC ELISA Kits). These defects included enteric nervous system hypoplasia, slow GI transit, diminished peristaltic reflex activity, and proliferation of crypt epithelial cells.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. This paper contains kinetics data of serotonin receptor (zeige HTR1B ELISA Kits) binding.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. Rhesus monkeys carrying the short rh5 (zeige RHO ELISA Kits)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (zeige HTR1A ELISA Kits) site is found in animals possessing this polymorphism.

5. We find that the short allele of the rh5 (zeige RHO ELISA Kits)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

6. rh5 (zeige RHO ELISA Kits)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

8. carriers of the low-expressing rh5 (zeige RHO ELISA Kits)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

9. evidence that the short allelic variant in rh5 (zeige RHO ELISA Kits)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

10. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaktionspartner

1. The 5-HTTLPR polymorphism was associated with neuroticism in women with Premenstrual Dysphoric Disorder. There is more evidence for a role of SERT polymorphisms in Postpartum Depression.

2. Study suggests that epigenetic mechanisms rather than 5-HTTLPR alone influence in vivo human serotonin transporter (5-HTT) availability.

3. SERT binding in the diencephalon is reduced in insulin (zeige INS ELISA Kits)-resistant subjects independently of body weight, while hypothalamic SERT binding tends to be lower in obesity, with no difference between insulin (zeige INS ELISA Kits)-resistant and insulin (zeige INS ELISA Kits)-sensitive subjects. This suggests that the metabolic perturbations associated with obesity independently affect SERT binding within the diencephalon.

4. The current meta-analysis provides new evidence for the robustness of the interaction between stress and 5-HTTLPR in depression.

5. Serotonin transporter (5-HTT) is responsible for removing serotonin from the synaptic cleft, returning it to the presynaptic neuron, thereby determining the extent, duration and spatial domain of the serotonergic activation.

6. Studied association of aggression and 5-HTTLPR, 5HTR1A, and 5HTR2A genetic polymorphisms in industrial Russian and traditional Tanzanian population groups.

7. the allelic distribution of solute carrier family-6 member-4 promoter region in Turkish athletes, is reported.

8. Both a genetic (5-HTTLPR) and cognitive (ruminative thinking) stress vulnerability may mutually increase the risk for stress-related abnormal eating patterns.

9. Overall, this investigation found evidence to suggest that 5-HTTLPR genotype affects the association of age and verbal episodic memory for males and females differently, with the predicted negative effect of S carriage present in males but not females.

10. The low expressing 5-HTTLPR genotype group (SA/SA genotype) is twice as likely to have a history of concussion compared to other genotypes.