anti-Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) Antikörper

SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SLC5A8 216225 Q8BYF6
SLC5A8 160728 Q8N695
SLC5A8 500820  
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Top anti-SLC5A8 Antikörper auf antikoerper-online.de

Showing 10 out of 68 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB WB Suggested Anti-SLC5A8 Antibody Titration:  0.2-1 ug/ml  Positive Control:  OVCAR-3 cell lysate Host:  Rabbit  Target Name:  SLC5A8  Sample Tissue:  Human OVCAR-3  Antibody Dilution:  1.0ug/ml 100 μL 2 bis 3 Tage
$319.00
Details
Human Kaninchen Unkonjugiert WB Host:  Rabbit  Target Name:  SLC5A8  Sample Type:  Fetal Kidney lysates  Antibody Dilution:  1.0ug/ml 100 μL 2 bis 3 Tage
$289.00
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Human Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$581.17
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-SLC5A8 Polyclonal Antibody, Unconjugated (ABIN762521) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL 3 bis 7 Tage
$317.90
Details
Human Kaninchen Unkonjugiert WB Western Blot at 1:1000 dilution Lane 1: SK-BR-3 whole cell lysate Lane 2: TT whole cell lysate Lysates/proteins at 20 ug per lane. 200 μL 2 bis 3 Tage
$515.63
Details
Maus Kaninchen Unkonjugiert WB Western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the detected the Mouse Slc5a8 protein (arrow). 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Alexa Fluor 594 IF (p)   100 μL 14 bis 21 Tage
$416.90
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Human Kaninchen Alexa Fluor 647 IF (p)   100 μL 14 bis 21 Tage
$416.90
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Human Kaninchen Alexa Fluor 555 IF (p)   100 μL 14 bis 21 Tage
$416.90
Details
Human Kaninchen Alexa Fluor 350 IF (p)   100 μL 14 bis 21 Tage
$416.90
Details

Am meisten referenzierte anti-SLC5A8 Antikörper

  1. Human Polyclonal SLC5A8 Primary Antibody für WB - ABIN2781721 : Zhang, Bao, Yang, Wu, Yu, Huang, Sun, Zheng, Li: Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. in The international journal of biochemistry & cell biology 2010 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal SLC5A8 Primary Antibody für WB - ABIN4892821 : Nedjadi, Moran, Al-Rammahi, Shirazi-Beechey: Characterization of butyrate transport across the luminal membranes of equine large intestine. in Experimental physiology 2014 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen SLC5A8 Interaktionspartner

Mouse (Murine) Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) Interaktionspartner

  1. Slc5a8 is an obligatory link between dietary fibre and mucosal immune system via the bacterial metabolite butyrate and that this transporter is a conditional tumour suppressor in colon linked to dietary fibre content.

  2. Data indicate oncogenic HRAS (HRAS(G12V)) as a potent mediator of SLC5A8 silencing in human nontransformed normal mammary epithelial cell lines and in mouse mammary tumors through DNMT1.

  3. Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-alpha on butyrate absorption could have potential therapeutic value.

  4. butyrate and propionate block the generation of dendritic cells from bone marrow stem cells, since Slc5a8 transports butyrate and propionate into cells, and these two bacterial metabolites inhibit histone deacetylases

  5. Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.

  6. In conventional mice with normal bacterial colonization of the intestinal tract, GPR109A and SLC5A8 are expressed on the apical membrane of epithelial cells lining the ileum and colon.

  7. CDX1 and CDX2 bind the promoter region of SLC5A8 and up-regulate its expression in cultured cells and in colonic epithelium.

  8. slc5a8 is expressed abundantly in the kidney and plays a role in the active reabsorption of lactate

  9. SMCT functions not only as a Na+-coupled transporter for short-chain fatty acids and lactate but also as a Na+-coupled transporter for the water-soluble vitamin nicotinic acid.

  10. The shared epigenetic inactivation of mSLC5A8 in mouse gliomas indicates an additional degree of commonality in the origin and/or pathway to tumorigenesis between primary human tumors and these mouse models of gliomas.

  11. Data describe the cellular localization of Slc5a8 in the murine gastrointestinal tract and kidney by in situ hybridization and immunohistochemistry.

  12. slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice have a role in the renal handling of lactate and urate

  13. SMCT1(SLC5A8) expression in intestinal tract was examined by immunofluorescence microscopy.

  14. These data provide the first evidence for the expression of SMCT1 and SMCT2 in the retina and for the cell-type specific distribution of these transporters within the retina.

  15. low-affinity transporter SMCT2 initiates lactate absorption in the early parts of the proximal tubule followed by the participation of the high-affinity transporter SMCT1 in the latter parts of the proximal tubule.

  16. Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT1/2 in the mouse kidney.

Human Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) Interaktionspartner

  1. SLC5A8 expression is repressed in human cervical cancer (CC) tumors and cell lines through epigenetic silencing.

  2. Results indicate that the SMCT1-PDZK1 interaction thus plays an important role in both lactate handling as well as urate reabsorption in the human kidney.

  3. Pendrin residues which are mutated in Pendred's syndrome are identical to those in the aligned position of sodium/iodide symporter (NIS) and apical iodide transporter (AIT).

  4. The present work reveals much lower iodide affinity in the pocket of human SMCT1 analogous to the putative iodide-binding pocket of human NIS.

  5. Human SMCT1 is regulated by insulin and SGK1.

  6. Data suggest positive correlation between BMI (body mass index)/waist circumference in morbidly obese or obese subjects and jejunal mucosa mRNA abundance of SMCT1; BMI was not significantly correlated with mRNA abundance for glucose transporters SGLT1 and GLUT2 or the low-affinity short-chain fatty acid/monocarboxylate transporter SMCT2.

  7. Underexpression of SLC5A8 is associated with hepatocellular carcinoma.

  8. Data suggest that SLC5A8, SLC5A5 (sodium-iodide symporter), and SLC26A4 (pendrin), the 3 known iodide transporters, are important in breast tissue metabolism in lactation and in breast neoplasms. [REVIEW]

  9. Gene silencing of SLC5A8 by hypermethylation was associated with poor prognosis in cases of node-negative stage I and II lung adenocarcinoma.

  10. Data indicate oncogenic HRAS (HRAS(G12V)) as a potent mediator of SLC5A8 silencing in human nontransformed normal mammary epithelial cell lines and in mouse mammary tumors through DNMT1.

  11. These results suggest that DNA methylation in the SLC5A8 promoter region may suppress the expression of SLC5A8 in lung tumor.

  12. SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function

  13. SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma.

  14. SLC5A8 has a role in prostate cancer risk and aggressiveness

  15. SLC5A8 is highly methylated in African American colon adenomas

  16. Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-alpha on butyrate absorption could have potential therapeutic value.

  17. Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.

  18. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9.

  19. results elucidate the mechanism underlying the regulation of SLC5A8 gene transcription and also define a novel regulatory sequence that may be used to increase expression of the SLC5A8 gene in cancer gene therapy

  20. SMCT1 possesses a anionic leak current that becomes significant whenever external Na(+) concentration is reduced

SLC5A8 Antigen-Profil

Protein Überblick

SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002

Genbezeichner und Symbole assoziert mit SLC5A8

  • solute carrier family 5 (iodide transporter), member 8 (Slc5a8) Antikörper
  • solute carrier family 5 member 8 (SLC5A8) Antikörper
  • solute carrier family 5 member 8 (Slc5a8) Antikörper
  • AIT Antikörper
  • RGD1564146 Antikörper
  • SMCT Antikörper
  • SMCT1 Antikörper

Bezeichner auf Proteinebene für SLC5A8

apical iodide transporter , putative , electrogenic sodium monocarboxylate cotransporter , sodium-coupled monocarboxylate transporter 1 , solute carrier family 5 member 8 , sodium-dependent monocarboxylate cotransporter , apical iodide transporter , sodium iodide-related cotransporter , solute carrier family 5 (iodide transporter), member 8

GENE ID SPEZIES
216225 Mus musculus
417932 Gallus gallus
482626 Canis lupus familiaris
615734 Bos taurus
160728 Homo sapiens
500820 Rattus norvegicus
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