Solute Carrier Family 3 (Cystine, Dibasic and Neutral Amino Acid Transporters, Activator of Cystine, Dibasic and Neutral Amino Acid Transport), Member 1 Proteine (SLC3A1)

SLC3A1 encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Zusätzlich bieten wir Ihnen SLC3A1 Antikörper (47) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC3A1 20532  
SLC3A1 6519 Q07837
Ratte SLC3A1 SLC3A1 29484 Q64319
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,639.51
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 25 bis 30 Tage
$215.05
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SLC3A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
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Human , , ,
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Weitere Proteine zu Solute Carrier Family 3 (Cystine, Dibasic and Neutral Amino Acid Transporters, Activator of Cystine, Dibasic and Neutral Amino Acid Transport), Member 1 (SLC3A1) Interaktionspartnern

Mouse (Murine) Solute Carrier Family 3 (Cystine, Dibasic and Neutral Amino Acid Transporters, Activator of Cystine, Dibasic and Neutral Amino Acid Transport), Member 1 (SLC3A1) Interaktionspartner

  1. a membrane protein AGT1/SLC7A13 is the second partner of rBAT.

  2. In 129S2/SvPasCrl mice, the heavy subunit RBAT of the tetrameric transporter of dibasic amino acids was absent in proximal tubules and identified was a single pathogenic mutation in a highly conserved region of the Slc3a1 gene.

  3. This study demonistrated that slc3a1 gene expression in mouse dorsal raphe nucleus

  4. a decreasing expression gradient of heterodimeric rBAT-b(0,+)AT along the proximal tubule is responsible for virtually all apical cystine reabsorption

  5. Slc3A1-deficient mice develop cystinuria type I

Human Solute Carrier Family 3 (Cystine, Dibasic and Neutral Amino Acid Transporters, Activator of Cystine, Dibasic and Neutral Amino Acid Transport), Member 1 (SLC3A1) Interaktionspartner

  1. Thirteen pediatric patients with cystine stones were evaluated in our clinic between 2012 and 2015. Gene mutations in SLC3A1 and SLC7A9 (zeige SLC7A9 Proteine) were investigated

  2. Spectrum of SLC3A1 and SLC7A9 (zeige SLC7A9 Proteine) mutations in cystinuria patients presenting with prenatal hyperechoic colon has been described.

  3. Analysis showing how different mutations in SLC3A1 and SLC7A9 (zeige SLC7A9 Proteine) affect severity of cystinuria.

  4. In a Saudi Arabian cohort of patients with cystinuria, two new variants in the SLC3A1 and SLC9A7 genes were discovered. All of the detected mutations were missense variants in three different exons, such as c.1711 T > A (p.Cys571Ser) (exon 10), c.1166C > T p.Thr389Met (exon 11) and c.1400 T > A p.Met467Lys (exon 8).

  5. Here, the authors report that the expression level of the solute carrier (zeige SERTAD2 Proteine) family 3, member 1 (SLC3A1), the cysteine carrier, tightly correlated with clinical stages and patients' survival. Elevated SLC3A1 expression accelerated the cysteine uptake and the accumulation of reductive glutathione (GSH), leading to reduced reactive oxygen species (ROS (zeige ROS1 Proteine)).

  6. We found a novel mutation in the acceptor region in exon 1 (SLC3A1 gene) and detected a heterozygosity status for the described patients.

  7. Five SLC3A1 and SLC7A9 (zeige SLC7A9 Proteine) mutations appear to be responsible for the genetic basis of cystinuria in the Greek-Cypriot patients

  8. Deletion of the rBAT C-terminal disulfide loop (residues 673-685) prevented maturation and prompted degradation of the transporter.

  9. Report no association of SLC3A1 mutations with clinical course of disease in cystinuria patients.

  10. We present a new pathogenic homozygous mutation, c.833T>C in exon 4 of SLC3A1 gene, in a girl with cystinuria, whose single symptom was an increasingly hyper-echogenic colon in the prenatal sonography as of 30 weeks of gestation.

SLC3A1 Protein Überblick

Protein Überblick

This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Genbezeichner und Symbole assoziert mit SLC3A1

  • solute carrier family 3, member 1 (Slc3a1)
  • solute carrier family 3 member 1 (SLC3A1)
  • solute carrier family 3 (amino acid transporter heavy chain), member 1 L homeolog (slc3a1.L)
  • solute carrier family 3 (amino acid transporter heavy chain), member 1 (slc3a1)
  • solute carrier family 3 member 1 (Slc3a1)
  • ATR1 Protein
  • CSNU1 Protein
  • D2H Protein
  • MGC131051 Protein
  • NBAT Protein
  • NTAA Protein
  • RBAT Protein
  • SLC3A1 Protein

Bezeichner auf Proteinebene für SLC3A1

amino acid transporter SLC3A1 , neutral and basic amino acid transport protein rBAT , solute carrier family 3, member 1 , solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 , membrane glycoprotein , neutral and basic amino acid transport protein rBAT-like , B(0,+)-type amino acid transport protein , SLC3A1 variant B , SLC3A1 variant C , SLC3A1 variant D , SLC3A1 variant E , SLC3A1 variant F , SLC3A1 variant G , amino acid transporter 1 , solute carrier family 3 (cystine, dibasic and neutral amino acid transporters), member 1 , D2 , NAA-TR , b(0,+)-type amino acid transport protein

GENE ID SPEZIES
20532 Mus musculus
403700 Canis lupus familiaris
428569 Gallus gallus
459194 Pan troglodytes
535601 Bos taurus
714035 Macaca mulatta
734933 Xenopus laevis
780365 Xenopus (Silurana) tropicalis
100009060 Oryctolagus cuniculus
100032244 Monodelphis domestica
100144588 Sus scrofa
100401185 Callithrix jacchus
100442610 Pongo abelii
100467387 Ailuropoda melanoleuca
100545774 Meleagris gallopavo
6519 Homo sapiens
29484 Rattus norvegicus
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