Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 Proteine (SLC12A1)

SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. Zusätzlich bieten wir Ihnen SLC12A1 Antikörper (109) und SLC12A1 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC12A1 6557 Q13621
SLC12A1 25065  
SLC12A1 20495 P55014
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Showing 7 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 70 bis 75 Tage
$16,301.58
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 70 bis 75 Tage
$11,428.37
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$717.00
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Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
Details

SLC12A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Rat (Rattus)
Mouse (Murine) ,
,

Weitere Proteine zu Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaktionspartnern

Human Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaktionspartner

  1. an association between primary hyperparathyroidism and loss of function mutation of SLC12A1, which may result in an aberrant threshold of the calcium sensing receptor (zeige CASR Proteine) at the level of the kidney, is reported.

  2. A novel variant in the SLC12A1 gene, c.1614T>A, which predicts a change from a tyrosine codon to a stop codon (p.Tyr538Ter) was found in two families with Bartter syndrome type I.

  3. Low SLC12A1 urine levels were associated with Bartter syndrome.

  4. Mutations in SLC12A1 gene is associated with Bartter syndrome.

  5. Urinary NKCC2 increased in chronic kidney disease patients and decreased in controls in response to hypertonic saline.

  6. The association between polymorphisms in KCNJ1 (zeige KCNJ1 Proteine), SLC12A1, and 7 other genes and calcium intake and colorectal neoplasia risk was studied.

  7. overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.

  8. NKCC2 mutations result in impaired apical targeting and function of NKCC2 transporter and give rise to a pathological phenotype known as type I Bartter syndrome. (Review)

  9. Data show that intracellular association between WNK1 (zeige WNK1 Proteine) and oxidative stress-responsive 1 (OSR1 (zeige OXSR1 Proteine)) is required for stimulation of OSR1 (zeige OXSR1 Proteine) and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (zeige SLC12A2 Proteine) and NKCC2 activities by osmotic stress.

  10. NKCC1 (zeige SLC12A2 Proteine) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.

Cow (Bovine) Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaktionspartner

  1. SLC12A1 (g.62382825G>A, p.Pro372Leu) is a hypomorphic or loss-of-function mutation and the hydrallantois with this mutation shows incomplete penetrance in Japanese Black cattle.

Mouse (Murine) Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaktionspartner

  1. The differential regulation of ROMK (zeige KCNJ1 Proteine), large-conductance Ca(2 (zeige CA2 Proteine)+)-activated K(+) (BK) channel (zeige KCNMA1 Proteine), BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 (zeige WNK1 Proteine) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.

  2. VAMP3 (zeige VAMP3 Proteine) is required for normal NKCC2 expression, renal function, and blood pressure.

  3. IL-1 (zeige IL1A Proteine) receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron.

  4. Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing.

  5. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.

  6. our results suggest that NKCCs are involved in insulin (zeige INS Proteine) secretion and that a single Slc12a2 (zeige SLC12A2 Proteine) allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1.

  7. Vasopressin (zeige AVP Proteine) plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport.

  8. In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described.

  9. increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase

  10. Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs.

SLC12A1 Protein Überblick

Protein Überblick

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

Genbezeichner und Symbole assoziert mit SLC12A1

  • si:ch211-220f12.1 (si:ch211-220f12.1)
  • solute carrier family 12 member 1 (SLC12A1)
  • solute carrier family 12 member 1 (Slc12a1)
  • solute carrier family 12, member 1 (Slc12a1)
  • AI788571 Protein
  • BSC1 Protein
  • D630042G03Rik Protein
  • DKFZp469A2020 Protein
  • mBSC1 Protein
  • Nkcc2 Protein
  • SLC12A1 Protein
  • urehr3 Protein

Bezeichner auf Proteinebene für SLC12A1

FERM domain-containing protein 4A , Na/K/Cl cotransporter , solute carrier family 12 (sodium/potassium/chloride transporters), member 1 , solute carrier family 12 member 1-like , NKCC2A variant A , Na-K-2Cl cotransporter , bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 , kidney-specific Na-K-Cl symporter , solute carrier family 12 member 1 , Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , apical Na(2Cl)K cotransporter , solute carrier family 12, member 1 , BSC1 , bumetanide-sensitive cotransporter type 1

GENE ID SPEZIES
564713 Danio rerio
714289 Macaca mulatta
100025723 Monodelphis domestica
100173185 Pongo abelii
100414428 Callithrix jacchus
100590969 Nomascus leucogenys
6557 Homo sapiens
25065 Rattus norvegicus
415433 Gallus gallus
478292 Canis lupus familiaris
407161 Bos taurus
100328575 Oryctolagus cuniculus
20495 Mus musculus
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