Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) ELISA Kits

SCN9A encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Zusätzlich bieten wir Ihnen SCN9A Antikörper (124) und SCN9A Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
SCN9A 20274  
SCN9A 78956 O08562
SCN9A 6335 Q15858
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Top SCN9A ELISA Kits auf antikoerper-online.de

Showing 10 out of 12 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Ratte 0.1 ng/mL 0.5-10 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
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Human 0.1 ng/mL 0.5-10 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
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Maus
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
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Meerschweinchen
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
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Schwein
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
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Hund
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
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Affe
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
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Kaninchen
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
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Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
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Huhn
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
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Weitere ELISA Kits für SCN9A Interaktionspartner

Cow (Bovine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. TNF-alpha (zeige TNF ELISA Kits) up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha (zeige TNF ELISA Kits)

  2. Findings suggest that the endothelin-1 (zeige EDN1 ELISA Kits)-induced down-regulation of NaV1.7 (SCN9A) diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau.

  3. Nav1.7-Ca2 (zeige CA2 ELISA Kits)+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK (zeige MAPK1 ELISA Kits)) and p38 (zeige MAPK14 ELISA Kits) attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK (zeige MAPK1 ELISA Kits) and p38 (zeige MAPK14 ELISA Kits)

  4. constitutively phosphorylated/activated ERK (zeige MAPK1 ELISA Kits) destabilizes Na(+) channel alpha-subunit (zeige POLG ELISA Kits) mRNA via translational event, which negatively regulates steady-state level of alpha-subunit (zeige POLG ELISA Kits) mRNA and cell surface expression of functional Na(+) channels.

  5. Na influx via scn9a converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. Nav1.7, known to regulate opioid receptor efficacy, interacts with the G protein-regulated inducer of neurite outgrowth (Gprin1), an opioid receptor-binding protein, demonstrating a physical and functional link between Nav1.7 and opioid signalling.

  2. the NaV1.7 channel is an important mechanism underlying hyperalgesia

  3. Voltage-gated sodium channel Nav1.7 controls the efficacy and balance of heterotrimeric guanine nucleotide-binding protein-coupled receptor (GPCR)-mediated pro- and antinociceptive intracellular signaling.

  4. the FGF13 (zeige FGF13 ELISA Kits)/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals

  5. this paper shows that Nav1.7, by coupling with CRMP1 (zeige CRMP1 ELISA Kits), mediates the axonal retrograde signaling of Sema3A (zeige SEMA3A ELISA Kits) in axonal guidance

  6. Experiments show that integration of synaptic inputs over time by Nav1.7 is critical for body weight regulation and reveal a mechanism for synaptic control of circuits regulating long term homeostatic functions.

  7. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk (zeige PENK ELISA Kits) mRNA and met-enkephalin protein in sensory neurons.

  8. Global Nav1.7 knockouts showed no defects in mechanical sensitivity or overall movement yet were completely insensitive to painful tactile, thermal, and chemical stimuli and were anosmic.

  9. Sodium channel Nav1.7, encoded by SCN9A, is expressed in DRG neurons and regulates their excitability.

  10. a novel regulatory mechanism that utilizes CRMP2 (zeige DPYSL2 ELISA Kits) SUMOylation to choreograph NaV1.7 trafficking.

Human Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. Nav1.7 is a substrate for Fyn (zeige FYN ELISA Kits) kinase.

  2. This study demonstrated that the higher expression Nav1.7 in human Dorsal Root Ganglion Neurons.

  3. cross-talk between distinct CRMP2 (zeige DPYSL2 ELISA Kits) posttranslational modifications is a key factor in determining NaV1.7 trafficking and localization

  4. Authors introduced mutations into Nav1.7 and Nav1.6 (zeige SCN8A ELISA Kits) that either enhance or impair slow inactivation (SI) in order to investigate their effects on resurgent currents. The results show that enhanced SI is accompanied by impaired resurgent currents, which suggests that SI may interfere with open-channel block.

  5. Hereditary Small fiber neuropathy has been described with pathogenic mutations in sodium channels [Nav1.7 (mostly), which lead to hyperexcitability of dorsal root ganglions. These gain-of-function mutations result in degeneration of small fibers.

  6. We exploited existing technologies in a novel manner to identify selective antagonists of NaV1.7. A full-deck high-throughput screen was developed for both NaV1.7 and cardiac NaV1.5 channels using a cell-based membrane potential dye FLIPR assay

  7. Genetic polymorphisms of SCN9A are associated with protection for severe neuropathy induced by oxaliplatin in digestive cancer.

  8. the results of this study provide mechanistic evidence for a time-dependent increase in intracellular [Ca2 (zeige CA2 ELISA Kits)+]i and energetic compromise in the neurites of dorsal root ganglia neurons expressing G856D mutant Nav1.7 channels.

  9. the FGF13 (zeige FGF13 ELISA Kits)/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals

  10. This study showed that gain-of-function attributes at the channel level and differential effects of physiologically relevant thermal stimuli on the excitability of DRG neurons expressing mutant and WT Nav1.7 channels, suggesting a cellular mechanism for warmth-triggered pain episodes in Erythromelalgia patients.

SCN9A Antigen-Profil

Beschreibung des Gens

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.

Genbezeichner und Symbole assoziert mit SCN9A

  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A) Antikörper
  • sodium voltage-gated channel alpha subunit 9 (SCN9A) Antikörper
  • sodium channel protein type 9 subunit alpha (LOC100016648) Antikörper
  • sodium channel, voltage-gated, type IX, alpha (Scn9a) Antikörper
  • sodium voltage-gated channel alpha subunit 9 (Scn9a) Antikörper
  • DKFZp459G084 Antikörper
  • ETHA Antikörper
  • FEB3B Antikörper
  • GEFSP7 Antikörper
  • mKIAA4197 Antikörper
  • Nav1.7 Antikörper
  • NE-NA Antikörper
  • NENA Antikörper
  • PN1 Antikörper
  • Scn2a Antikörper
  • SCN9A Antikörper
  • SFNP Antikörper

Bezeichner auf Proteinebene für SCN9A

sodium channel, voltage-gated, type IX, alpha subunit , sodium channel protein type 9 subunit alpha-like , peripheral sodium channel 1 , sodium channel 25 , sodium channel protein type 9 subunit alpha , sodium channel protein type IX subunit alpha , sodium channel, voltage-gated, type IX, alpha polypeptide , voltage-gated sodium channel alpha subunit Nav1.7 , voltage-gated sodium channel subunit alpha Nav1.7 , sodium channel, voltage-gated, type 9, alpha polypeptide , hNE-Na , neuroendocrine sodium channel , nas , schwann cell sodium channel , sodium channel alpha-subunit

GENE ID SPEZIES
488381 Canis lupus familiaris
533065 Bos taurus
100016648 Monodelphis domestica
100172961 Pongo abelii
100385702 Callithrix jacchus
100482886 Ailuropoda melanoleuca
100516701 Sus scrofa
100583836 Nomascus leucogenys
20274 Mus musculus
78956 Rattus norvegicus
6335 Homo sapiens
100009210 Oryctolagus cuniculus
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