anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) Antikörper

The protein encoded by SCN4B is one of several sodium channel beta subunits. Zusätzlich bieten wir Ihnen Sodium Channel, Voltage-Gated, Type IV, beta Subunit Proteine (5) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SCN4B 6330 Q8IWT1
SCN4B 315611 Q7M730
SCN4B 399548 Q7M729
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Top anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit Antikörper auf antikoerper-online.de

Showing 10 out of 36 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of SCN4B expression in U87MG (A), Jurkat (B) whole cell lysates. 200 μL 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HepG2/Jurkat cells, using SCN4B Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Verfügbar
$363.46
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB ABIN6275576 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert IHC (p), WB   100 μg 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using SCN4B antibody (ABIN1874702) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s. 100 μL 11 bis 13 Tage
$366.77
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB Western blot analysis of extracts of U-87, using SCN4B antibody. The lane on the left is treated with the antigen-specific peptide. 100 μL 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert WB 100 μL 11 bis 16 Tage
$312.70
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cell lines, using SCN4B antibody (ABIN5971181) at 1/1000 dilution. 100 μL 11 bis 16 Tage
$426.40
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg 2 bis 3 Tage
$302.50
Details

Am meisten referenzierte anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit Antikörper

  1. Mammalian Monoclonal SCN4B Primary Antibody für ISt, IHC - ABIN1304847 : Buffington, Rasband: Na+ channel-dependent recruitment of Nav?4 to axon initial segments and nodes of Ranvier. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)

Weitere Antikörper gegen Sodium Channel, Voltage-Gated, Type IV, beta Subunit Interaktionspartner

Human Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) Interaktionspartner

  1. Data identified one rare nonsynonymous heterozygous variant, p.Gly8Ser, in SCN4B that was significantly associated with a risk of ventricular tachycardia (VT) in two independent populations.

  2. this study reports the cryo-electron microscopy structure of the human Nav1.4-beta1 complex at 3.2-A resolution.

  3. SCN4B overexpression reduces cancer cell invasiveness and tumour progression.

  4. Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer.

  5. Data suggest that extracellular domains of SCN4B directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); SCN4B homodimers appear to play role in cell-cell adhesion.

  6. The expression of a human-specific isoform of the voltage-gated sodium channel subunit SCN4B was significantly correlated to lifetime alcohol consumption

  7. Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome.

  8. Human Nav1.6 channels generate larger resurgent currents than human Nav1.1 channels, but the SCN4B-derived Navbeta4 peptide does not protect either isoform from use-dependent reduction.

  9. In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes.

  10. results suggest the presence of a docking site that is maintained by a cysteine bridge buried within the hydrophobic core of beta4.

  11. this is the first study to demonstrate an association of SCN4B mutations with AF, suggesting SCN4B as a novel AF susceptibility gene.

  12. SCN5A-SCN4B were found to be essential for positive selection of CD4(+) T cells.

  13. The researchers found evidence of an association between SCN4B subunit mutations and sudden infant death syndrome pathogenesis.

  14. The paroxysmal extreme pain disorder associated Nav1.7 missense mutations M1627K, T1464I and V1299F increase Navbeta4 peptide-mediated resurgent sodium currents, in contrast to the erythromelalgia associated I848T and L858H Nav1.7 missense mutations.

  15. molecular cloning and characterization of sodium channel beta4

  16. SCN4B is a long QT syndrome susceptibility gene.

  17. Co-expression of the beta1 subunit impeded slow inactivation elicited by a 30-s depolarization, such that the voltage dependence was right shifted (depolarized) and recovery was hastened.

  18. Loss of function mutations in sodium channel beta-subunits were identified in patients with atrial fibrillation and were associated with a distinctive ECG phenotype

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) Interaktionspartner

  1. Data suggest that extracellular domains of Scn4b directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); Scn4b homodimers appear to play role in cell-cell adhesion.

  2. Scn4b(-/-) animals have deficits in motor coordination and balance and that firing rates in Scn4b(-/-) Purkinje neurons are markedly attenuated.

  3. NaVbeta4 plays a blocking role that indicates the relative importance of different residues in inducing open-channel block.

  4. Data show that Na(V)beta4 (Scn4b} expression determines multiple aspects of Na channel gating, thereby regulating excitability in cultured cerebellar granule cells.

  5. down-regulation of Scn4b may lead to abnormalities of sodium channel and neurite degeneration in the striatum of Huntington's disease transgenic mice

  6. These data suggest that beta1 and beta4 have antagonistic roles, the former favoring inactivation, and the latter favoring activation.

Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) Antigen-Profil

Protein Überblick

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.

Genbezeichner und Symbole assoziert mit SCN4B

  • sodium voltage-gated channel beta subunit 4 (SCN4B) Antikörper
  • sodium voltage-gated channel beta subunit 4 (Scn4b) Antikörper
  • sodium channel, type IV, beta (Scn4b) Antikörper
  • sodium channel, voltage-gated, type IV, beta a (scn4ba) Antikörper
  • Gm1471 Antikörper
  • LQT10 Antikörper
  • Navbeta4 Antikörper
  • scn4b.1 Antikörper
  • scn4b1 Antikörper
  • zgc:165389 Antikörper

Bezeichner auf Proteinebene für SCN4B

sodium channel subunit beta-4 , sodium channel accessory subunit , sodium channel beta 4 subunit , sodium channel, type 4, beta subunit , sodium channel, type IV, beta , sodium channel, type IV, beta polypeptide , voltage gated sodium channel beta 4 subunit , voltage-gated sodium channel beta 4 subunit locus 1 , voltage-gated sodium channel beta4.1 subunit

GENE ID SPEZIES
6330 Homo sapiens
315611 Rattus norvegicus
399548 Mus musculus
538100 Bos taurus
566069 Danio rerio
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