Sodium Channel, Voltage-Gated, Type I, beta Proteine (SCN1B)

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. Zusätzlich bieten wir Ihnen Sodium Channel, Voltage-Gated, Type I, beta Antikörper (73) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SCN1B 20266 P97952
Ratte SCN1B SCN1B 29686 Q00954
SCN1B 6324 Q07699
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Showing 9 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$230.67
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Hefe Schimpanse His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,306.33
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,306.33
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,306.33
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Hefe Hund His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,306.33
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SCN1B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
,
Human , ,
, ,

Weitere Proteine zu Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Interaktionspartnern

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Interaktionspartner

  1. This study demonstrated that the sodium channel beta1 subunit proteins encoded by this mutant gene are expressed at the surface of neuronal cell bodies.

  2. Loss of Scn1b caused increased amplitude of tetrodotoxin-sensitive INa, delayed after-depolarizations, triggered beats, changed Ca2+ transients,and susceptibility ventricular arrhythmias.

  3. Study showed that Scn1b is widely expressed at axon initial segments across the mouse brain, there is considerable heterogeneity in the proportion of Scn1b-positive neurons and the amount of expression between and within brain regions

  4. beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis

  5. Scn1b mutant subicular and layer 2/3 pyramidal neurons had increased action potential firing rates, presumably as a consequence of their increased input resistance

  6. Stronger expressions of SCN5a, SCN1b and Kir2.1 were observed in ventricular-like and atrial-like cells compared to that of pacemaker-like cardiomyocytes.

  7. Scn1b is critical for neuronal proliferation, migration, and pathfinding during the critical postnatal period of brain development.

  8. The results presented here identify Navbeta1 as a component of native neuronal Kv4.2-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability.

  9. Scn1b regulates the electrical excitability of nociceptive DRG neurons in vivo by modulating both I(Na) and I(K).

  10. propose reciprocity of function between Scn1b (beta1) and Na(v)1.6 such that beta1-mediated neurite outgrowth requires Na(v)1.6-mediated I(Na), and Na(v)1.6 localization and consequent high-frequency firing require beta1

  11. The primary sodium channels present in ventricular myocytes are composed of Na(v)1.5 plus beta2 and/or beta4 subunits in intercalated disks and Na(v)1.1, Na(v)1.3, and Na(v)1.6 plus beta1 and/or beta3 subunits in the transverse tubules.

  12. Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons

  13. Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b.

  14. Electrocardiograms from Scn1b knockout mice displayed longer heart rate intervals and extended long QT syndromes.

  15. Voltage-gated Na(+) channel beta1 subunits signal via multiple pathways on multiple timescales and play important roles in the postnatal development of the CNS

  16. Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion.

Human Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Interaktionspartner

  1. Scn1b and Fxyd1 expression was significantly downregulated in HSCR colon.

  2. The lack of genotype-phenotype concordance among families, combined with the high frequency of previously reported mutations in the Genome Aggregation Database browser, suggests that SCN1B is not a monogenic cause of BrS or SADS.

  3. we confirm the recessive inheritance of 2 novel SCN1B mutations in 5 children from 3 families with developmental epileptic encephalopathy. The recessive inheritance and early death in these patients is consistent with the Dravet-like phenotype observed in Scn1b(-/-) mice.

  4. This report provides the first genetic evidence of SCN1B mutation causing the Benign Familial Infantile Epilepsy (BFIE) phenotype.

  5. Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome.

  6. SCN1B gene mutations that reduce sodium channel current may provide a mechanistic link between Atrioventricular nodal reentrant tachycardia and Brugada syndrome and predispose to expression of both phenotypes.

  7. In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes.

  8. We also identified an SCN1B T189M variant in 2 probands with lone AF and in 1 of 250 control subjects.

  9. Study showed that the human SCN1B C121W epilepsy mutation leads to decreased axon initial segments expression of SCN1B in heterozygous CW mice and a complete lack of SCN1B in homozygous WW mice

  10. data revealed SCN1Bb as a susceptibility gene responsible for LQTS

  11. High SCN1B expression is associated with increased tumour growth and metastasis in breast cancer.

  12. Hippocampal networks of a NaV beta1 transgenic mouse model of genetic epilepsy show enhanced excitability.

  13. experimental data indicate that sodium channel voltage-gated type I beta subunit (Navbeta1b)/H162P results in reduced sodium channel activity functionally affecting the ventricular action potential.

  14. sodium channel polymorphisms are associated with epilepsy

  15. SCN1B mutation is not a common cause of Dravet syndrome.

  16. results suggest that R214Q variation in SCN1Bb is a functional polymorphism that may serve as a modifier of the substrate responsible for Brugada syndrome or SIDS phenotypes

  17. Our study supports the association of SCN1Bb with BrS.

  18. Mutation analysis of the SCN1B, SCN1A and GABRG2 genes in children affected by Genetic (Generalised) Epilepsy with Febrile Seizures plus was performed

  19. A novel seizure-causing mechanism is suggested for NaV1.2beta1 in patients harboring mutant C121W subunit: increased channel excitability at elevated temperature.

  20. SCN1B is the gene responsible in one out of six Tunisian families with febrile seizures (FS) that may contribute susceptibility for the five others.

Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Protein Überblick

Protein Überblick

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SCN1B

  • sodium channel, voltage-gated, type I, beta (Scn1b)
  • sodium voltage-gated channel beta subunit 1 (Scn1b)
  • sodium voltage-gated channel beta subunit 1 (SCN1B)
  • GEFSP1 Protein

Bezeichner auf Proteinebene für SCN1B

sodium channel subunit beta-1 , sodium channel, voltage-gated, type I, beta polypeptide , sodium channel voltage-gated type 1 beta polypeptide , sodium channel voltage-gated type I beta polypeptide , sodium channel, voltage-gated, type 1, beta polypeptide , sodium channel beta-1 subunit , sodium channel beta 1-subunit

GENE ID SPEZIES
20266 Mus musculus
29686 Rattus norvegicus
6324 Homo sapiens
484584 Canis lupus familiaris
618204 Bos taurus
100009211 Oryctolagus cuniculus
747705 Pan troglodytes
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