Sodium Channel, Voltage-Gated, Type I, beta Proteine (SCN1B)

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. Zusätzlich bieten wir Ihnen Sodium Channel, Voltage-Gated, Type I, beta Antikörper (71) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SCN1B 20266 P97952
Ratte SCN1B SCN1B 29686 Q00954
SCN1B 6324 Q07699
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Showing 9 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$225.40
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,306.33
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Hefe Hund His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,306.33
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,306.33
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Hefe Schimpanse His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,306.33
Details

SCN1B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
,
Human , ,
, ,

Weitere Proteine zu Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Interaktionspartnern

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Interaktionspartner

  1. Loss of Scn1b caused increased amplitude of tetrodotoxin-sensitive INa (zeige INA Proteine), delayed after-depolarizations, triggered beats, changed Ca2 (zeige CA2 Proteine)+ transients,and susceptibility ventricular arrhythmias.

  2. Study showed that Scn1b is widely expressed at axon initial segments across the mouse brain, there is considerable heterogeneity in the proportion of Scn1b-positive neurons and the amount of expression between and within brain regions

  3. Scn1b mutant subicular and layer 2/3 pyramidal neurons had increased action potential firing rates, presumably as a consequence of their increased input resistance

  4. Stronger expressions of SCN5a (zeige SCN5A Proteine), SCN1b and Kir2.1 (zeige KCNJ2 Proteine) were observed in ventricular-like and atrial-like cells compared to that of pacemaker-like cardiomyocytes.

  5. Scn1b is critical for neuronal proliferation, migration, and pathfinding during the critical postnatal period of brain development.

  6. The results presented here identify Navbeta1 as a component of native neuronal Kv4.2 (zeige KCND2 Proteine)-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability.

  7. Scn1b regulates the electrical excitability of nociceptive DRG neurons in vivo by modulating both I(Na) and I(K).

  8. propose reciprocity of function between Scn1b (beta1) and Na(v)1.6 such that beta1-mediated neurite outgrowth requires Na(v)1.6-mediated I(Na), and Na(v)1.6 localization and consequent high-frequency firing require beta1

  9. The primary sodium channels present in ventricular myocytes are composed of Na(v)1.5 plus beta2 and/or beta4 subunits in intercalated disks and Na(v)1.1, Na(v)1.3 (zeige SCN3A Proteine), and Na(v)1.6 plus beta1 and/or beta3 subunits in the transverse tubules.

  10. Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b.

Human Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Interaktionspartner

  1. we confirm the recessive inheritance of 2 novel SCN1B mutations in 5 children from 3 families with developmental epileptic encephalopathy. The recessive inheritance and early death in these patients is consistent with the Dravet-like phenotype observed in Scn1b(-/-) mice.

  2. This report provides the first genetic evidence of SCN1B mutation causing the Benign Familial Infantile Epilepsy (BFIE) phenotype.

  3. Contribution of Cardiac Sodium Channel (zeige SCN5A Proteine) beta-Subunit (zeige POLG Proteine) Variants to Brugada Syndrome.

  4. SCN1B gene mutations that reduce sodium channel current may provide a mechanistic link between Atrioventricular nodal reentrant tachycardia and Brugada syndrome and predispose to expression of both phenotypes.

  5. In a nonreferred nationwide Danish cohort of SIDS (zeige IDS Proteine) cases, up to 5/66 (7.5%) of SIDS (zeige IDS Proteine) cases can be explained by genetic variants in the sodium channel complex genes.

  6. We also identified an SCN1B T189M variant in 2 probands with lone AF and in 1 of 250 control subjects.

  7. Study showed that the human SCN1B C121W epilepsy mutation leads to decreased axon initial segments expression of SCN1B in heterozygous CW mice and a complete lack of SCN1B in homozygous WW mice

  8. High SCN1B expression is associated with increased tumour growth and metastasis in breast cancer.

  9. experimental data indicate that sodium channel voltage-gated type I beta subunit (Navbeta1b)/H162P results in reduced sodium channel activity functionally affecting the ventricular action potential.

  10. SCN1B mutation is not a common cause of Dravet syndrome.

Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Protein Überblick

Protein Überblick

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SCN1B

  • sodium channel, voltage-gated, type I, beta (Scn1b)
  • sodium voltage-gated channel beta subunit 1 (Scn1b)
  • sodium voltage-gated channel beta subunit 1 (SCN1B)
  • GEFSP1 Protein

Bezeichner auf Proteinebene für SCN1B

sodium channel subunit beta-1 , sodium channel, voltage-gated, type I, beta polypeptide , sodium channel voltage-gated type 1 beta polypeptide , sodium channel voltage-gated type I beta polypeptide , sodium channel, voltage-gated, type 1, beta polypeptide , sodium channel beta-1 subunit , sodium channel beta 1-subunit

GENE ID SPEZIES
20266 Mus musculus
29686 Rattus norvegicus
6324 Homo sapiens
484584 Canis lupus familiaris
618204 Bos taurus
100009211 Oryctolagus cuniculus
747705 Pan troglodytes
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