anti-Sirtuin 5 (SIRT5) Antikörper

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 5 Proteine (18) und Sirtuin 5 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIRT5 23408 Q9NXA8
SIRT5 68346 Q8K2C6
SIRT5 306840 Q68FX9
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Top anti-Sirtuin 5 Antikörper auf antikoerper-online.de

Showing 10 out of 180 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-SIRT5 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SIRT5 <br /> Antibody Titration: 5.0 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: Human heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$245.00
Details
Human Maus Unkonjugiert FACS, IF, IHC (p), WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
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Human Maus Unkonjugiert FACS, IF, IHC (p), WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Human Maus Unkonjugiert FACS, WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: SIRT5 Antibody [NBP1-86013] - Staining of human adrenal gland shows strong granular staining of the cytioplasm in cortical cells. Western Blot: SIRT5 Antibody [NBP1-86013] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY415885) 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of anti-SIRT5 Pab (ABIN390180) in Jurkat cell line lysate (35 µg/lane). SIRT5(arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details

SIRT5 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Sirtuin 5 Antikörper

  1. Human Polyclonal SIRT5 Primary Antibody für IHC (fro), IF (p) - ABIN1387080 : Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. in Acta oto-laryngologica 2014 (PubMed)

  2. Human Polyclonal SIRT5 Primary Antibody für WB - ABIN252349 : Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. in Cancer 2011 (PubMed)

  3. Cow (Bovine) Polyclonal SIRT5 Primary Antibody für WB - ABIN2778619 : Mahlknecht, Ho, Letzel, Voelter-Mahlknecht: Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization. in Cytogenetic and genome research 2006 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal SIRT5 Primary Antibody für IHC (p), WB - ABIN390180 : Wang, Yi, Li, Cai, He, Ni, Zhou, Cheng, Jin, Fan, Qiu: Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. in BMC cancer 2014 (PubMed)

  5. Human Polyclonal SIRT5 Primary Antibody für IHC, IHC (p) - ABIN4353920 : Lv, Liu, Cheng, Yu, Xiong, Hu, Tang, Zeng, Sang: SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer. in Scientific reports 2015 (PubMed)

Weitere Antikörper gegen Sirtuin 5 Interaktionspartner

Human Sirtuin 5 (SIRT5) Interaktionspartner

  1. This study showed that SIRT5 supports the anaplerotic entry of glutamine (zeige GFPT1 Antikörper) into the TCA cycle in malignant phenotypes of CRC (zeige CALR Antikörper) via activating GLUD1 (zeige GLUD1 Antikörper).

  2. Results show that SIRT5 binds to, desuccinylates and inhibits PKM2 activity. Increased levels of reactive oxygen species (ROS) decreases succinylation and activity of PKM2 by increasing its binding to SIRT5. Moreover, inhibition of SIRT5 suppresses tumor cell proliferation through desuccinylation of PKM2 K498.

  3. The function of the three mitochondrial sirtuins (SIRT3 (zeige SIRT3 Antikörper), SIRT4 (zeige SIRT4 Antikörper), SIRT5) and their role in disease are reviewed.

  4. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH (zeige NQO1 Antikörper) homeostasis and redox potential by promoting IDH2 (zeige IDH2 Antikörper) desuccinylation and G6PD (zeige G6PD Antikörper) deglutarylation.

  5. Results demonstrated presence of endogenous SIRT5 in mitochondria of cultured SH-EP cells, identified down-regulation of cellular oxidative stress by SIRT5 as one of the possible mechanisms mediating the anti-apoptotic effect of SIRT5 in SH-EP cells.

  6. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  7. a side chain-to-side chain cyclic pentapeptide harboring a central N(epsilon)-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1 (zeige SIRT1 Antikörper)/2/3/6) inhibitor against human SIRT5-catalyzed deacylation reaction.

  8. Data indicate that compared to non-neoplastic endometria (NNE), endometrial cancer (EC) showed SIRT7 (zeige SIRT7 Antikörper) mRNA overexpression, whereas SIRT1 (zeige SIRT1 Antikörper), SIRT2 (zeige SIRT2 Antikörper), SIRT4 (zeige SIRT4 Antikörper) and SIRT5 were underexpressed, and no significant differences were observed for SIRT3 (zeige SIRT3 Antikörper) and SIRT6 (zeige SIRT6 Antikörper).

  9. Use of a pan (zeige SUPT6H Antikörper)-sirtuin (zeige SIRT1 Antikörper) inhibitor and shRNA-mediated protein knockdown led us to uncover a role for the NAD(+)-dependent family of sirtuins, and in particular for SIRT2 (zeige SIRT2 Antikörper) and SIRT5, in the regulation of the necroptotic cell death program

  10. mutual cooperation between Y102 and R105 residues in promoting the desuccinylation versus deacetylation reaction in SIRT5.

Mouse (Murine) Sirtuin 5 (SIRT5) Interaktionspartner

  1. findings reveal a key role for SIRT5 in maintaining cardiac oxidative metabolism under pressure overload to ensure survival

  2. Deletion of Sirt5 in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 (zeige CRMP1 Antikörper) and to mitochondrial fragmentation.

  3. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH (zeige FDXR Antikörper) homeostasis and redox potential by promoting IDH2 (zeige IDH2 Antikörper) desuccinylation and G6PD (zeige G6PD Antikörper) deglutarylation.

  4. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  5. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) overexpression significantly increased the expression of sirtuin 3 (SIRT3 (zeige SIRT3 Antikörper)) and sirtuin 5 (SIRT5).

  6. In the cochlea, the expression of SIRT1 (zeige SIRT1 Antikörper), 3, and 5 (both mRNA and protein) was decreased in the old mice

  7. These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.

  8. Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (zeige SDHA Antikörper)), implicating alteration in SDH (zeige SDS Antikörper) activity as causative of the injury.

  9. SIRT5 has a role in cellular metabolism with a multiple enzymatic activities

  10. SIRT3 (zeige SIRT3 Antikörper) and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase (zeige ACADVL Antikörper)

Cow (Bovine) Sirtuin 5 (SIRT5) Interaktionspartner

  1. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.

Sirtuin 5 (SIRT5) Antigen-Profil

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit anti-Sirtuin 5 (SIRT5) Antikörper

  • sirtuin 5 (SIRT5) Antikörper
  • sirtuin 5 (Sirt5) Antikörper
  • sirtuin 5 (sirt5) Antikörper
  • sirtuin 5 L homeolog (sirt5.L) Antikörper
  • sirtuin 5 (CC1G_00083) Antikörper
  • 0610012J09Rik Antikörper
  • 1500032M05Rik Antikörper
  • AV001953 Antikörper
  • sir2l5 Antikörper
  • SIRT5 Antikörper
  • sirt5-a Antikörper
  • zgc:92288 Antikörper

Bezeichner auf Proteinebene für anti-Sirtuin 5 (SIRT5) Antikörper

NAD-dependent deacetylase sirtuin-5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial , NAD-dependent protein deacylase sirtuin-5, mitochondrial , SIR2-like protein 5 , regulatory protein SIR2 homolog 5 , silent mating type information regulation 2, S.cerevisiae, homolog 5 , sir2-like 5 , sirtuin type 5 , Regulatory protein SIR2 homolog 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial , NAD-dependent protein deacylase sirtuin-5A, mitochondrial , regulatory protein SIR2 homolog 5-a , sirtuin (silent mating type information regulation 2 homolog) 5 , sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin 5 , nad-dependent deacetylase sirtuin-5

GENE ID SPEZIES
23408 Homo sapiens
68346 Mus musculus
306840 Rattus norvegicus
420834 Gallus gallus
436878 Danio rerio
478726 Canis lupus familiaris
496346 Xenopus laevis
507347 Bos taurus
700855 Macaca mulatta
747069 Pan troglodytes
6013501 Coprinopsis cinerea okayama7130
100125966 Sus scrofa
100170199 Xenopus (Silurana) tropicalis
100173543 Pongo abelii
100528250 Ictalurus punctatus
100718110 Cavia porcellus
100339154 Oryctolagus cuniculus
100860989 Capra hircus
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