Sirtuin 3 Proteine (SIRT3)

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen SIRT3 Antikörper (236) und SIRT3 Kits (27) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top SIRT3 Proteine auf

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 10 bis 12 Tage
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
Escherichia coli (E. coli) Huhn Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage

SIRT3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
Mouse (Murine)
Rat (Rattus)

Am meisten referenzierte SIRT3 Proteine

  1. Human SIRT3 Protein expressed in Wheat germ - ABIN1320045 : Pacella-Ince, Zander-Fox, Lan: Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age. in Human reproduction (Oxford, England) 2014 (PubMed)

Weitere Proteine zu Sirtuin 3 (SIRT3) Interaktionspartnern

Human Sirtuin 3 (SIRT3) Interaktionspartner

  1. Authors have identified a novel mechanism by which P53 was inactivated via SIRT3 in PTEN-deficient cells. This may shed light on the mechanisms underlying the malignancy of PTEN-deficient NSCLC.

  2. SIRT3 could enhance the drug sensitivity of hepatoma cells to an array of chemotherapeutic agents through glutathione S-transferase pi 1 (zeige GSTP1 Proteine)/JNK (zeige MAPK8 Proteine) signaling pathway

  3. Data suggest that pharmacological approaches for augmenting sirtuin 3 (SIRT3) might have therapeutic potential in organ fibrosis in systemic sclerosis (SSc (zeige CYP11A1 Proteine)).

  4. Sirtuin 3 protects against urban particulate matter-induced autophagy in human bronchial epithelial cells.

  5. Contrary to what has been known in solid tumors, in K562 human leukemia cells, Sirt3 plays an opposite role in relieving oxidative stress. Basal but not enhanced autophagy activity maintains ubiquitination-proteasomal degradation of Sirt3 to limit reactive oxygen species level.

  6. SIRT3 whole muscle protein content was unaltered after fasting.

  7. Current study reveal Sirt3 as a novel regulator coupling mitophagy and apoptosis, two important cellular processes that determine cellular survival and death.

  8. The function of the three mitochondrial sirtuins (SIRT3, SIRT4 (zeige SIRT4 Proteine), SIRT5 (zeige SIRT5 Proteine)) and their role in disease are reviewed.

  9. Results show that curcumin at low doses can increase the level of sirtuins including sirtuin 1 (zeige SIRT1 Proteine) and sirtuin 3) without delaying senescence of vascular smooth muscle (VSMC) cells.

  10. survival curves showed that higher SIRT3 expression is correlated to a poorer prognosis for patients with grade 3 breast cancer. In conclusion, SIRT3 could be a therapeutic target for breast cancer, improving the effectiveness of CDDP and TAM (zeige CCNA1 Proteine) treatments.

Mouse (Murine) Sirtuin 3 (SIRT3) Interaktionspartner

  1. Study provides evidence that present that Sirt3 expression protected pancreatic beta cells from lipotoxicity by antagonizing oxidative stress-induced (zeige SQSTM1 Proteine) cell damage.

  2. Sirt3 activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1 (zeige FOXO1 Proteine), which in turn alleviates myocardial hypertrophy.

  3. The authors provide evidence that inactivation of PIKfyve (zeige PIKFYVE Proteine) by the selective inhibitor STA (zeige SULT2A1 Proteine) suppresses excessive mitochondrial reactive oxygen species production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts.

  4. the regulation of mitochondrial ROS (zeige ROS1 Proteine) by SOD2 (zeige SOD2 Proteine) and Sirt3 plays an important role in fine-tuning the Osteoclast differentiation program.

  5. conclude that Sirt3 does not considerably impact NET formation, platelet function, or venous thrombosis in healthy young mice

  6. vitamin C and edaravone effectively protected macrophages from stress-induced cytotoxicity, accompanied by downregulated SIRT3 expression and AMPK (zeige PRKAA1 Proteine) phosphorylation, and decreased level of autophagy response. Taken together, we conclude that a SIRT3/AMPK (zeige PRKAA1 Proteine)/autophagy network orchestrates in the protective effect of resveratrol in macrophages.

  7. Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC (zeige PGC Proteine)-1a-SOD2 (zeige SOD2 Proteine)-mediated regulation of mitochondrial function

  8. findings reveal an unexpected mechanism for SIRT3 regulation via SIRT1 (zeige SIRT1 Proteine)-mediated deacetylation. Improving mitochondrial SIRT3 functions by inhibiting SIRT3 acetylation may offer a new therapeutic approach for obesity- and aging-related diseases associated with mitochondrial dysfunction.

  9. Sirt3 expression in bone marrow cells increases during aging, suggesting that Sirt3 promotes age-related adipogenesis and osteoclastogenesis associated with bone loss. These findings identify Sirt3 as an important regulator of adipogenesis and skeletal homeostasis in vivo and identify Sirt3 as a potential target for the treatment of osteoporosis.

  10. These data suggest a novel role for SIRT3 deficiency in mediating alveolar epithelial cell mtDNA damage, apoptosis, and lung fibrosis.-

Cow (Bovine) Sirtuin 3 (SIRT3) Interaktionspartner

  1. The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.

  2. The results indicate that the variations in the class I sirtuin (zeige SIRT1 Proteine) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  3. The expression profile of sirtuin 1 (zeige SIRT1 Proteine) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Genbezeichner und Symbole assoziert mit Sirtuin 3 Proteine (SIRT3)

  • sirtuin 3 (sirt3)
  • sirtuin 3 (SIRT3)
  • sirtuin 3 (Sirt3)
  • 2310003L23Rik Protein
  • AI848213 Protein
  • Sir2l3 Protein
  • sirtuin Protein
  • zgc:158774 Protein

Bezeichner auf Proteinebene für Sirtuin 3 Proteine (SIRT3)

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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