anti-Sirtuin 3 (SIRT3) Antikörper

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen SIRT3 Proteine (19) und SIRT3 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Top anti-SIRT3 Antikörper auf antikoerper-online.de

Showing 10 out of 230 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Human kidney WB Suggested Anti-SIRT3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Thymus 100 μL 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert ELISA, WB ABIN185498 (0.2µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 bis 7 Tage
$429.84
Details
Maus Ziege Unkonjugiert ELISA, FACS, IF, WB ABIN768568 (0.3µg/ml) staining of Mouse Heart lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. ABIN768568 Immunofluorescence analysis of paraformaldehyde fixed NIH3T3 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI 100 μg 6 bis 7 Tage
$429.84
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SIRT3 Antibody   Titration: 5 ug/ml   Positive Control: Fetal thymus 100 μL 2 bis 3 Tage
$229.00
Details
Hund Kaninchen Unkonjugiert WB WB Suggested Anti-SIRT3 Antibody Titration:  2.5ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate 100 μL 2 bis 3 Tage
$249.00
Details
Human Kaninchen Unkonjugiert WB 100 μg 2 bis 3 Tage
$245.00
Details
Human Kaninchen Unkonjugiert WB Anti-SIRT3 Picoband antibody,  All lanes: Anti SIRT3  at 0.5ug/ml WB: Recombinant Human SIRT3 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD Anti-SIRT3 Picoband antibody, All lanes: Anti SIRT3  at 0.5ug/ml Lane 1: Rat Spleen Tissue Lysate at 50ug Lane 2: Human Placenta Tissue Lysate at 50ug Lane 3: HELA Whole Cell Lysate at 40ug Lane 4: COLO320 Whole Cell Lysate at 40ug Predicted bind size: 44KD  Observed bind size: 44KD 100 μg 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed A549, using SIRT3, antibody at 1:200 dilution. IHC-P Image Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using SIRT3, antibody at 1:500 dilution. 100 μL 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert WB   200 μL 13 bis 14 Tage
$487.50
Details
Maus Ziege Unkonjugiert ELISA, WB 0.1 mg 2 bis 3 Tage
$515.63
Details

Am meisten referenzierte anti-SIRT3 Antikörper

  1. Human Polyclonal SIRT3 Primary Antibody für WB - ABIN549536 : Werner, Kuhlmann, Shen, Uecker, Schardt, Dimova, Orfaniotou, Dhaunchak, Brinkmann, Möbius, Guarente, Casaccia-Bonnefil, Jahn, Nave: Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)
    Show all 3 Pubmed References

  2. Cow (Bovine) Polyclonal SIRT3 Primary Antibody für IHC, WB - ABIN2779610 : Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal SIRT3 Primary Antibody für ELISA, WB - ABIN269822 : Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal SIRT3 Primary Antibody für IF, IHC - ABIN6147792 : Xu, Gao, Zhang, Wei, Chen, Dai, Zeng, Zhao: SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model. in Oxidative medicine and cellular longevity 2017 (PubMed)

  5. Human Polyclonal SIRT3 Primary Antibody für IHC, WB - ABIN6147791 : Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015 (PubMed)

  6. Human Polyclonal SIRT3 Primary Antibody für ELISA, ICC - ABIN6265092 : Li, Chen, Yang, He, He, Xia, Zhang, Xiang: Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3. in International journal of oncology 2018 (PubMed)

Weitere Antikörper gegen SIRT3 Interaktionspartner

Human Sirtuin 3 (SIRT3) Interaktionspartner

  1. SIRT3 could be a target for colon cancer.

  2. these results identified a tumor-suppressive role for Sirt3 deficiency in tongue cancer via activation of the JNK-Fis1 axis and subsequent initiation of fatal mitochondrial fission.

  3. SIRT3 promoted mitochondrial biogenesis by increasing both the expression and deacetylation of TFAM in clear cell renal cell carcinoma.

  4. that SIRT3 dysfunction leads to p53-mediated mitochondrial and neuronal damage in Alzheimer's disease

  5. Myricetin nanoliposomes induced SIRT3-mediated glycolytic metabolism leading to glioblastoma cell death.

  6. High SIRT3 expression is associated with diabetes and hypothyroidism.

  7. SIRT3 knockout cells upregulated the diversion of glutamine into de novo nucleotide synthesis through hyperactive mTORC1 signaling.

  8. Increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of pyruvate dehydrogenase and ATP synthase that are essential for cardiac energy metabolism.

  9. The Sirt3-mediated protein deacetylation plays an important role in regulating oxidative metabolism and antioxidant defence in stem cell differentiation, and that Sirt3 deficiency may be related to insulin resistance.

  10. SIRT3 gene expression is altered in adipose tissue from overweight and obese subjects compared to normal weight subjects.

  11. MiR-494-3p inhibition exerted a neuroprotective role in 1-Methyl-4-phenylpyridinium induced Parkinson's disease by targeting SIRT3, providing a possible therapeutic strategy for Parkinson's disease patients.

  12. ZEB1 silenced SIRT3 expression via interaction with MBD1 to promote aerobic glycolysis in pancreatic cancer.

  13. The SIRT3 promoted FOXO3A expression by attenuating Wnt/beta-catenin pathway, thereby inhibiting EMT and migration of prostate cancer cells.

  14. Sirtuin-3 mitochondrial NAD-dependent deacetylase (SIRT3) is responsible for serine hydroxymethyltransferase 2 (SHMT2)deacetylation in colorectal cancer (CRC) cells. The increased expression of SIRT3 in human CRC samples is correlated with poorer postoperative overall survival.

  15. genetic manipulation of Sirt3 revealed that amyloid-beta increased levels of total tau acetylated tau through its modulation of Sirt3.

  16. The SIRT3 protein level negatively correlated with advanced glycation end products accumulation and the grade of intervertebral disc degeneration degeneration.

  17. Melatonin's functions in the mitochondria are highly diverse, not unlike those of sirtuin 3 (SIRT3). SIRT3 is an NAD+-dependent deacetylase which regulates, among many functions, the redox state of the mitochondria. Recent data proves that melatonin and SIRT3 post-translationally collaborate in regulating free radical generation and removal from mitochondria. [review]

  18. Master athletes had lower levels of miR-7, while mRNA or protein levels of SIRT3, SIRT1, SOD2, and FOXO1 levels were significantly higher in the vastus lateralis muscle of master athletes compared to muscles of age-matched controls.

  19. BER modulated autophagy in DOX-treated H9c2 cardiomyoblasts. Interestingly, mitochondrial biogenesis markers were upregulated in in BER/DOX-treated cells. Sirt3 over-expression contributes to decrease DOX cytotoxicity on H9c2 cardiomyoblasts, while BER can be used as a modulator of Sirtuin function and cell quality control pathways to decrease DOX toxicity.

  20. The loss of Sirt3 triggered fatal mitochondrial fission by suppressing the Akt/PTEN pathway.

Mouse (Murine) Sirtuin 3 (SIRT3) Interaktionspartner

  1. Sirt3 plays an important role in regulating Abeta-induced cerebral hypometabolism in mouse model of Alzheimer disease.

  2. The observations of this study suggest that SIRT3 deficiency-induced brain mitochondrial dysfunction and neuroinflammation in metabolic syndrome may play a role in late-life cognitive decline.

  3. while NMN protected perfused hearts against ischemia-reperfusion (injury , this protection was insensitive to the SIRT1 inhibitor splitomicin. Although NMN-induced cardioprotection was absent in Sirt3(-/-) hearts (recovery 9+/-5%), this was likely due to enhanced baseline injury in Sirt3(-/-) , since similar injury levels in WT hearts also blunted protective efficacy of NMN

  4. The SIRT3/SOD2 is required for regulating mitochondrial stress and plays a vital role in osteoblast differentiation and bone formation.

  5. Sirt3 loss-of-function enhances experimental thrombosis in vivo via an increase of neutrophil extracellular traps and elevation of TF suggesting thrombo-protective effects of endogenous Sirt3.

  6. SIRT3 activity promotes allogeneic donor T cell responses and reactive oxygen species production without altering T cell cytokine or cytolytic functions

  7. The role of SIRT3 in the development of nonalcoholic fatty liver disease, impaired intestinal permeability and gut microbiota dysbiosis.

  8. that SIRT3 dysfunction leads to p53-mediated mitochondrial and neuronal damage in Alzheimer's disease

  9. Findings suggest that adipocyte SIRT3 is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism.

  10. The level of Sirt3 in cerebral infarct region is decreased after ischemic stroke.

  11. Sirt3 deficiency aggravates contrast-induced acute kidney injury.

  12. Study provides evidence that neuronal networks in the hippocampus of mice adapt to intermittent food deprivation by up-regulating GABAergic inhibitory neurotransmission via a mechanism requiring SIRT3 and involving a reduction in mitochondrial oxidative stress.

  13. SIRT3 knockout cells upregulated the diversion of glutamine into de novo nucleotide synthesis through hyperactive mTORC1 signaling.

  14. Increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of pyruvate dehydrogenase and ATP synthase that are essential for cardiac energy metabolism.

  15. Study results demonstrated that Sirt3 was downregulated in cartilage chondrocytes from IL-1beta induced osteoarthritis mouse model and Sirt3 expression is associated with the progression of osteoarthritis, it is also involved in the clearance of dysfunctional mitochondria via mitophagy in chondrocytes.

  16. long-term potentiation was impaired in the Sirt3-knockout mice

  17. The data of this study suggested that Sirt3 KO mice show neuroprotection by a compensatory rise in Sirt1 rather than the loss of Sirt3 after stroke.

  18. these results established the SIRT3-Foxo3a-catalase pathway as a critical factor in the maintenance of endothelial homeostasis and point to an important role of EndoMT in the vascular pathology of renal fibrosis, which may provide a new therapeutic target to impede the progression of hypertensive renal injury.

  19. study demonstrated that SIRT3 deficiency exacerbated CCl 4 -induced impairment of the liver in mice, and the mechanism might be related to enhanced oxidative stress.

  20. Studied antiobesity effect of myricetin in adipose tissue and found effect is mediated thru upregulation of sirtuin 3 (SIRT3).

Cow (Bovine) Sirtuin 3 (SIRT3) Interaktionspartner

  1. the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were firstly reported, respectively. The association analysis indicated that the indels within SIRT1 and SIRT2 genes were significantly associated with body measurement traits such as body weight, chest circumference, height at hip cross, hip width, body height, etc.

  2. The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.

  3. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  4. The expression profile of sirtuin 1 and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Antigen-Profil

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Genbezeichner und Symbole assoziert mit anti-Sirtuin 3 (SIRT3) Antikörper

  • sirtuin 3 (sirt3) Antikörper
  • sirtuin 3 (SIRT3) Antikörper
  • sirtuin 3 (Sirt3) Antikörper
  • 2310003L23Rik Antikörper
  • AI848213 Antikörper
  • Sir2l3 Antikörper
  • sirtuin Antikörper
  • zgc:158774 Antikörper

Bezeichner auf Proteinebene für anti-Sirtuin 3 (SIRT3) Antikörper

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

GENE ID SPEZIES
558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
Ausgewählte Anbieter für anti-SIRT3 (SIRT3) Antikörper
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