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SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen SIRT3 Kits (27) und SIRT3 Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 236 products:
Human Polyclonal SIRT3 Primary Antibody für IHC (p), WB - ABIN390178
Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. in The Journal of biological chemistry 2010
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Cow (Bovine) Polyclonal SIRT3 Primary Antibody für IHC, WB - ABIN2779610
Onyango, Celic, McCaffery, Boeke, Feinberg: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Polyclonal SIRT3 Primary Antibody für ELISA, WB - ABIN269822
Shi, Wang, Stieren, Tong: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. in The Journal of biological chemistry 2005
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Hamster Polyclonal SIRT3 Primary Antibody für IHC (p), WB - ABIN652184
Kawamura, Uchijima, Horike, Tonami, Nishiyama, Amano, Asano, Kurihara, Kurihara: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. in The Journal of clinical investigation 2010
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SIRT3 could enhance the drug sensitivity of hepatoma cells to an array of chemotherapeutic agents through glutathione S-transferase pi 1 (zeige GSTP1 Antikörper)/JNK (zeige MAPK8 Antikörper) signaling pathway
Data suggest that pharmacological approaches for augmenting sirtuin 3 (SIRT3) might have therapeutic potential in organ fibrosis in systemic sclerosis (SSc (zeige CYP11A1 Antikörper)).
Sirtuin 3 protects against urban particulate matter-induced autophagy in human bronchial epithelial cells.
Contrary to what has been known in solid tumors, in K562 human leukemia cells, Sirt3 plays an opposite role in relieving oxidative stress. Basal but not enhanced autophagy activity maintains ubiquitination-proteasomal degradation of Sirt3 to limit reactive oxygen species level.
SIRT3 whole muscle protein content was unaltered after fasting.
Current study reveal Sirt3 as a novel regulator coupling mitophagy and apoptosis, two important cellular processes that determine cellular survival and death.
The function of the three mitochondrial sirtuins (SIRT3, SIRT4 (zeige SIRT4 Antikörper), SIRT5 (zeige SIRT5 Antikörper)) and their role in disease are reviewed.
Results show that curcumin at low doses can increase the level of sirtuins including sirtuin 1 (zeige SIRT1 Antikörper) and sirtuin 3) without delaying senescence of vascular smooth muscle (VSMC) cells.
survival curves showed that higher SIRT3 expression is correlated to a poorer prognosis for patients with grade 3 breast cancer. In conclusion, SIRT3 could be a therapeutic target for breast cancer, improving the effectiveness of CDDP and TAM (zeige CCNA1 Antikörper) treatments.
There were no significant correlations between LRP130, SIRT3, or PGC-1alpha mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130, SIRT3, and PGC-1alpha were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle.
Sirt3 activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1 (zeige FOXO1 Antikörper), which in turn alleviates myocardial hypertrophy.
The authors provide evidence that inactivation of PIKfyve (zeige PIKFYVE Antikörper) by the selective inhibitor STA (zeige SULT2A1 Antikörper) suppresses excessive mitochondrial reactive oxygen species production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts.
the regulation of mitochondrial ROS (zeige ROS1 Antikörper) by SOD2 (zeige SOD2 Antikörper) and Sirt3 plays an important role in fine-tuning the Osteoclast differentiation program.
conclude that Sirt3 does not considerably impact NET formation, platelet function, or venous thrombosis in healthy young mice
vitamin C and edaravone effectively protected macrophages from stress-induced cytotoxicity, accompanied by downregulated SIRT3 expression and AMPK (zeige PRKAA1 Antikörper) phosphorylation, and decreased level of autophagy response. Taken together, we conclude that a SIRT3/AMPK (zeige PRKAA1 Antikörper)/autophagy network orchestrates in the protective effect of resveratrol in macrophages.
Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC (zeige PGC Antikörper)-1a-SOD2 (zeige SOD2 Antikörper)-mediated regulation of mitochondrial function
findings reveal an unexpected mechanism for SIRT3 regulation via SIRT1 (zeige SIRT1 Antikörper)-mediated deacetylation. Improving mitochondrial SIRT3 functions by inhibiting SIRT3 acetylation may offer a new therapeutic approach for obesity- and aging-related diseases associated with mitochondrial dysfunction.
Sirt3 expression in bone marrow cells increases during aging, suggesting that Sirt3 promotes age-related adipogenesis and osteoclastogenesis associated with bone loss. These findings identify Sirt3 as an important regulator of adipogenesis and skeletal homeostasis in vivo and identify Sirt3 as a potential target for the treatment of osteoporosis.
These data suggest a novel role for SIRT3 deficiency in mediating alveolar epithelial cell mtDNA damage, apoptosis, and lung fibrosis.-
Diminished Sirt3 expression and redox inactivation of Sirt3 led to SOD2 (zeige SOD2 Antikörper) inactivation and contributes to hypertension.
The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.
The results indicate that the variations in the class I sirtuin (zeige SIRT1 Antikörper) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
The expression profile of sirtuin 1 (zeige SIRT1 Antikörper) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
, NAD-dependent deacetylase sirtuin-3, mitochondrial
, NAD-dependent protein deacetylase sirtuin-3, mitochondrial
, SIR2-like protein 3
, mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
, regulatory protein SIR2 homolog 3
, silent mating type information regulation 2, S.cerevisiae, homolog 3
, sir2-like 3
, sirtuin type 3
, SIRT3 mitochondrial
, NAD-dependent deacetylase sirtuin-3
, NAD-dependent protein deacetylase sirtuin-3
, SIRT3L mitochondrial
, mitochondrial protein lysine deacetylase
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3